Natural antidotes and management of metal toxicity

Amadi, Cecilia Nwadiuto; Offor, Samuel James; Frazzoli, Chiara; Orisakwe, Orish Ebere

doi:10.1007/s11356-019-05104-2

Cited by 84 publications

(51 citation statements)

References 227 publications

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“…Heavy metal are classified into essential and nonessential metals 1 . Essential metals including manganese, cobalt, iron, and zinc, are present in trace amount in the body and have pivotal roles as cofactors, coenzymes, and/or mediators.…”

Section: Introductionmentioning

confidence: 99%

“…Essential metals including manganese, cobalt, iron, and zinc, are present in trace amount in the body and have pivotal roles as cofactors, coenzymes, and/or mediators. In contrast, if human or any organism exposed to a high amount of these metals, they become poisonous 1 , 2 . While, environmental contamination and exposure to numerous nonessential heavy metals which have no known benefit for human, animal and aquatic organisms physiology 3 – 5 , such as lead (Pb), arsenic cadmium, and mercury, is a dangerous growing universal problem 4 , 5 , especially in some developing countries including Egypt 6 .…”

Section: Introductionmentioning

confidence: 99%

“…Numerous edible plants are known to possess antioxidant properties, as they are rich in phytoantioxidants, namely phenolic compounds, flavonoids, etc. 1 , 26 , 29 . These natural antioxidants may improve metal mobilization from the body, reduce the dose of potential toxic chelators, and restrict the redistribution of toxic metal from one organ to another 30 .…”

Section: Introductionmentioning

confidence: 99%

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Synergistic protective effect of Beta vulgaris with meso-2,3-dimercaptosuccinic acid against lead-induced neurotoxicity in male rats

Shaban

El-Kader

Mogahed

et al. 2021

Sci Rep

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Lead (Pb) toxicity is one of the most prevalent causes of human neurotoxicity. The available chelator drugs used now have many adverse effects. So, in this study, the protective role of Betavulgaris juice (BVJ) on rat neurotoxicity induced by Pb was evaluated and the results were compared with the results of dimercaptosuccinic acid (DMSA, as used drug). Additionally, the synergistic effect of BVJ and DMSA against Pb-induced neurotoxicity was assessed. The study focused on the determination of the antioxidant, anti-inflammatory, and neurological potential of BVJ (alone, and with DMSA) towards lead-induced neurotoxicity. Also, the characterization of BVJ was studied. The results showed that BVJ contains considerable quantities of polyphenols, triterpenoids, and betalains which play an important role as antioxidants and anti-inflammatory. BVJ exhibited a protective effect against neurotoxicity via the reduction of Pb levels in blood and brain. Moreover, BVJ decreased the oxidative stress, inflammation, and cell death induced by Pb. Also, BVJ regulated the activities of acetylcholine esterase and monoamine oxidase-A which changed by Pb toxicity. BVJ and DMSA combination displayed a synergistic antineurotoxic effect (combination index ˂ 1). These results were in harmony with brain histopathology. Conclusion: BVJ has a powerful efficacy in the protection from brain toxicity via diminishing Pb in the brain and blood circulation, resulting in the prevention of the oxidative and inflammatory stress. Treatment with BVJ in combination with DMSA revealed a synergistic effect in the reduction of neurotoxicity induced by Pb. Also, the antioxidant and anti-inflammatory effects of the BVJ lead to the improvement of DMSA therapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synergistic protective effect of Beta vulgaris with meso-2,3-dimercaptosuccinic acid against lead-induced neurotoxicity in male rats

Shaban

El-Kader

Mogahed

et al. 2021

Sci Rep

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“…e antioxidant/ neuroprotective activity of green tea catechins like EGCG is linked to their iron chelation properties [86]. Recent studies have shown that the phenolic hydroxyl groups on the aromatic rings of EGCG confer the antioxidant and iron-chelating activities [44,87,88].…”

Section: Teasmentioning

confidence: 99%

Management of Iron Overload in Resource Poor Nations: A Systematic Review of Phlebotomy and Natural Chelators

Orisakwe

Amadi

Frazzoli

2020

Journal of Toxicology

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Iron is an essential element and the most abundant trace metal in the body involved in oxygen transport and oxygen sensing, electron transfer, energy metabolism, and DNA synthesis. Excess labile and unchelated iron can catalyze the formation of tissue-damaging radicals and induce oxidative stress. English abstracts were identified in PubMed and Google Scholar using multiple and various search terms based on defined inclusion and exclusion criteria. Full-length articles were selected for systematic review, and secondary and tertiary references were developed. Although bloodletting or phlebotomy remains the gold standard in the management of iron overload, this systematic review is an updated account of the pitfalls of phlebotomy and classical synthetic chelators with scientific justification for the use of natural iron chelators of dietary origin in resource-poor nations.

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“…The use of herbal medicine has been shown to be effective in the treatment of infertility (Akram, Pakdel, Ahmadi, & Zare, 2012). An inherent characteristic of many antioxidants in addition to their free radical scavenging property is chelation of metal ions (Amadi, Offor, Frazzoli, & Orisakwe, 2019). Studies have examined the effects of micronutrients on heavy metal toxicity and have revealed a reduction in toxicity (Rostan, DeBuys, Madey, & Pinnell, 2002; Xu et al., 2005).…”

Section: Introductionmentioning

confidence: 99%

Low‐dose heavy metal mixture (lead, cadmium and mercury)‐induced testicular injury and protective effect of zinc andCostus aferin wistar albino rats

et al. 2020

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Global concern about male infertility is growing, and this affects approximately 50% of infertile couples (Agarwal, Mulgund, Hamada, & Chyatte, 2015). Environmental and occupational exposures to heavy metals have led to various deleterious damages to the biological system, of which infertility is one. The results of various studies associate male factors with infertility in 20%-50% of cases (Boivin, Bunting, Collins, & Nygren, 2007; Jarow et al., 2002). Aetiological factors implicated in male infertility can be categorised as follows: (a) pre-testicular, such as endocrine and coital disorders; (b) testicular, including abnormalities of sperm production; and (c) post-testicular, such as anatomic obstructions (Carvalho, Zhang, & Lupski, 2011). Various environmental toxicants such as lead (Pb), cadmium (Cd) and mercury (Hg) have been reported to adversely affect spermatogenesis in man and rats, which can cause low sperm count, abnormal sperm morphology and poor semen quality (Agarwal et al., 2015; Wong. et al., 2010), released by the industrial processes and natural forces into our surroundings. As a result, humans are exposed by inhalation of polluted air, consumption of contaminated food and water and usage

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Natural antidotes and management of metal toxicity

Cited by 84 publications

References 227 publications

Synergistic protective effect of Beta vulgaris with meso-2,3-dimercaptosuccinic acid against lead-induced neurotoxicity in male rats

Synergistic protective effect of Beta vulgaris with meso-2,3-dimercaptosuccinic acid against lead-induced neurotoxicity in male rats

Management of Iron Overload in Resource Poor Nations: A Systematic Review of Phlebotomy and Natural Chelators

Low‐dose heavy metal mixture (lead, cadmium and mercury)‐induced testicular injury and protective effect of zinc andCostus aferin wistar albino rats

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