Natural antioxidants inhibit oxidative stress-induced changes in the morphology and motility of cells

Xiang, Xiong; Kwame, Amakye William; Qing, Yinglu; Li, Shan; Wang, Min; Ren, Jiaoyan

doi:10.1016/j.fbio.2023.102442

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…To further validate the proliferative potential of EBNP, the EdU staining assay, an accurate method to detect DNA synthesis in the S-phase of the cell cycle, 21 was used in the present work. As shown in Figure 2E, there was a greater proportion of cells at the proliferation (red fluorescence) stage in the control group in comparison with the UVB-irradiation model group.…”

Section: Skin Wound Healing Effects Of Ebnp 331 Ebnp Protects Hacat C...mentioning

confidence: 99%

Identification of the Wound Healing Activity Peptidome of Edible Bird’s Nest Protein Hydrolysate and the In Silico Evaluation of Its Transport and Absorption Potential in Skin

Wang,

Qing,

Fan

et al. 2024

J. Agric. Food Chem.

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In this study, edible bird's nest (EBN) was proven to be a suitable source of bioactive peptides via enzymatic hydrolysis. The ultrafiltration component of the EBN peptides (EBNPs, Mw < 3 000 Da) could be responsible for moderate moisture retention and filaggrin synthesis. It was found that EBNP had a great capacity to protect HaCaT keratinocytes from DNA damage caused by UVB-irradiation and enhance wound healing by increasing the migratory and proliferative potential of cells. Furthermore, the external application of EBNP could effectively repair high glycolic acid concentration-induced skin burns in mice. A total of 1 188 peptides, predominantly the hydrophobic amino acids (e.g., Leu, Val, Tyr, Phe), were identified in the EBNP by liquid chromatography with tandem mass spectrometry (LC-MS/MS). Molecular docking showed that hydrophobic tripeptides from EBNP had a good binding affinity to proton-dependent oligopeptide transporter PepT1. Our data indicated that the hydrophobic amino acid-rich EBNP plays an important role in skin wound healing.

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Section: Skin Wound Healing Effects Of Ebnp 331 Ebnp Protects Hacat C...mentioning

confidence: 99%

Identification of the Wound Healing Activity Peptidome of Edible Bird’s Nest Protein Hydrolysate and the In Silico Evaluation of Its Transport and Absorption Potential in Skin

Wang,

Qing,

Fan

et al. 2024

J. Agric. Food Chem.

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“…Oxidative stress represents a prominent avenue through which cellular toxicity can manifest. Oxidative damage can cause uncontrolled cell signaling; morphological and physiological changes in cell and cellular organelles; and alterations in cell motility, apoptosis, cell death, and carcinogenesis [152,153]. Thus, the utility of antioxidants is indispensable in averting or, in most instances, mitigating the deleterious consequences induced by ROS.…”

Section: Role Of Nanoparticles (Nps) As Reactive Oxygen Species (Ros)...mentioning

confidence: 99%

“…Functioning as reducing agents, antioxidants engage in redox reactions by donating electrons or hydrogen atoms. By adhering to specific constraints, this enzymatic process facilitates the seamless execution of cellular functions while concurrently thwarting the oxidation of pivotal structural constituents and other indispensable elements [153,155,156].…”

Section: Role Of Nanoparticles (Nps) As Reactive Oxygen Species (Ros)...mentioning

confidence: 99%

Role of Nanoparticle-Conjugates and Nanotheranostics in Abrogating Oxidative Stress and Ameliorating Neuroinflammation

Patel,

Kevadiya,

Bajwa

et al. 2023

Antioxidants

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Oxidative stress is a deteriorating condition that arises due to an imbalance between the reactive oxygen species and the antioxidant system or defense of the body. The key reasons for the development of such conditions are malfunctioning of various cell organelles, such as mitochondria, endoplasmic reticulum, and Golgi complex, as well as physical and mental disturbances. The nervous system has a relatively high utilization of oxygen, thus making it particularly vulnerable to oxidative stress, which eventually leads to neuronal atrophy and death. This advances the development of neuroinflammation and neurodegeneration-associated disorders such as Alzheimer’s disease, Parkinson’s disease, epilepsy, dementia, and other memory disorders. It is imperative to treat such conditions as early as possible before they worsen and progress to irreversible damage. Oxidative damage can be negated by two mechanisms: improving the cellular defense system or providing exogenous antioxidants. Natural antioxidants can normally handle such oxidative stress, but they have limited efficacy. The valuable features of nanoparticles and/or nanomaterials, in combination with antioxidant features, offer innovative nanotheranostic tools as potential therapeutic modalities. Hence, this review aims to represent novel therapeutic approaches like utilizing nanoparticles with antioxidant properties and nanotheranostics as delivery systems for potential therapeutic applications in various neuroinflammation- and neurodegeneration-associated disease conditions.

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Synthesis of lipophilic vitamin C and evaluation of its antioxidant performance in sunflower seed oil frying

Fu,

Liu,

et al. 2024

Food Chemistry

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Natural antioxidants inhibit oxidative stress-induced changes in the morphology and motility of cells

Cited by 3 publications

References 27 publications

Identification of the Wound Healing Activity Peptidome of Edible Bird’s Nest Protein Hydrolysate and the In Silico Evaluation of Its Transport and Absorption Potential in Skin

Identification of the Wound Healing Activity Peptidome of Edible Bird’s Nest Protein Hydrolysate and the In Silico Evaluation of Its Transport and Absorption Potential in Skin

Role of Nanoparticle-Conjugates and Nanotheranostics in Abrogating Oxidative Stress and Ameliorating Neuroinflammation

Synthesis of lipophilic vitamin C and evaluation of its antioxidant performance in sunflower seed oil frying

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