Natural aporphine alkaloids: A comprehensive review of phytochemistry, pharmacokinetics, anticancer activities, and clinical application

Sun, Jing; Zhan, Xingtian; Wang, Weimin; Yang, Xiaojie; Liu, Yichen; Yang, Huanzhi; Deng, Jianjun; Yang, Haixia

doi:10.1016/j.jare.2023.11.003

Cited by 7 publications

(1 citation statement)

References 124 publications

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“…Comprising one of the largest groups of natural isoquinolines, aporphine alkaloids are widely distributed in flowering plant families, (e.g., Annonaceae, Aristolochiaceae, Berberidaceae, Canellaceae, Eupomatiaceae, Hernandiaceae, Lauraceae, Leguminosae, Magnoliaceae, Menispermaceae, Monimiaceae, Papaveraceae, Piperaceae, Ranunculaceae, Rhamnaceae, Saururaceae, and Symplocaceae families). − The tetracyclic backbone of naturally occurring aporphine alkaloids is typically decorated with substituents such as hydroxyl, methoxy, and methylenedioxy groups on the two aromatic rings. The aporphine alkaloids are a privileged scaffold in drug discovery, as natural aporphine alkaloids are reported to have a myriad of pharmacological activities including antioxidant, antitumor, anticonvulsant, antiplasmodial, antiparkinsonian, antimalarial, antiprotozoal, and cytotoxic effects …”

Section: Benzylisoquinoline Alkaloids (Bias)mentioning

confidence: 99%

Natural Product-Inspired Dopamine Receptor Ligands

Dorogan,

Namballa,

Harding

2024

J. Med. Chem.

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Due to their evolutionary bias as ligands for biologically relevant drug targets, natural products offer a unique opportunity as lead compounds in drug discovery. Given the involvement of dopamine receptors in various physiological and behavioral functions, they are linked to numerous diseases and disorders such as Parkinson’s disease, schizophrenia, and substance use disorders. Consequently, ligands targeting dopamine receptors hold considerable therapeutic and investigative promise. As this perspective will highlight, dopamine receptor targeting natural products play a pivotal role as scaffolds with unique and beneficial pharmacological properties, allowing for natural product-inspired drug design and lead optimization. As such, dopamine receptor targeting natural products still have untapped potential to aid in the treatment of disorders and diseases related to central nervous system (CNS) and peripheral nervous system (PNS) dysfunction.

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