Natural Attenuation of Pharmaceuticals in the Aquatic Environment and Role of Phototransformation

Mohapatra, Sanjeeb; Menon, N. Gayathri; Padhye, Lokesh P.; Tatiparti, Sankara Sarma V.; Mukherji, Soumyo

doi:10.1007/978-981-15-4599-3_3

Cited by 11 publications

(2 citation statements)

References 111 publications

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“…Immediately after consumption, antiviral drugs undergo series of biotransformation such as glucuronidation, sulfoxidation, dimethylamine N-demethylation, and sulfate conjugation and finally excreted from the human body to the greater extent as metabolites, including active ones, mostly in urine ( Nannou et al, 2020 ). Therefore, the drug residues and metabolites can be continuously transported through hospital and household wastewater to WWTPs and may pose additional challenges in their detection in complex environmental matrices ( Mohapatra et al, 2018 ). Since WWTPs are not specifically designed to remove such drug residues, WWTPs become a major source of antivirals and their metabolites in the surface water bodies, especially during the pandemics ( Nannou et al, 2020 ).…”

Section: Antiviral Drugs: Environmental Occurrence and Potential Ecotmentioning

confidence: 99%

A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance

Kumar

Mazumder

Mohapatra

et al. 2021

Journal of Hazardous Materials

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In this review, we present the environmental perspectives of the viruses and antiviral drugs related to SARS-CoV-2. The present review paper discusses occurrence, fate, transport, susceptibility, and inactivation mechanisms of viruses in the environment as well as environmental occurrence and fate of antiviral drugs, and prospects (prevalence and occurrence) of antiviral drug resistance (both antiviral drug resistant viruses and antiviral resistance in the human). During winter, the number of viral disease cases and environmental occurrence of antiviral drug surge due to various biotic and abiotic factors such as transmission pathways, human behaviour, susceptibility, and immunity as well as cold climatic conditions. Adsorption and persistence critically determine the fate and transport of viruses in the environment. Inactivation and disinfection of virus include UV, alcohol, chemical-base methods but the susceptibility of virus against these methods varies. Wastewater treatment plants (WWTPs) are major sources of antiviral drugs and their metabolites and transformation products. Ecotoxicity of antiviral drug residues against aquatic organisms have been reported, however more threatening is the development of antiviral resistance, both in humans and in wild animal reservoirs. In particular, emergence of antiviral drug-resistant viruses via exposure of wild animals to high loads of antiviral residues during the current pandemic needs further evaluation.

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Section: Antiviral Drugs: Environmental Occurrence and Potential Ecotmentioning

confidence: 99%

A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance

Kumar

Mazumder

Mohapatra

et al. 2021

Journal of Hazardous Materials

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“…The fate of micropollutants in a typical municipal sewage treatment plant depends on their physicochemical properties, such as molecular weight, octanol–water partition coefficient (K ow ), acid dissociation constant (pKa), solubility, or biodegradability. Other external factors are the sludge treatment method and the operation condition of the wastewater treatment plant [ 35 , 36 ]. It is estimated that more than 70% of relatively hydrophobic contaminants from groups, such as heavy metals, persistent organic pollutants (POPs), brominated flame retardants and some personal care products (PCP), surfactants, plastic additives, hormones, some PCP, some medicines, and household chemicals are usually well disposed of in wastewater treatment plants [ 37 , 38 ].…”

Section: Pharmaceuticals In Sewage Sludgementioning

confidence: 99%

From Sewage Sludge to the Soil—Transfer of Pharmaceuticals: A Review

Bolesta

Głodniok

Styszko

2022

IJERPH

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Sewage sludge, produced in the process of wastewater treatment and managed for agriculture, poses the risk of disseminating all the pollutants contained in it. It is tested for heavy metals or parasites, but the concentration of pharmaceuticals in the sludge is not controlled. The presence of these micropollutants in sludge is proven and there is no doubt about their negative impact on the environment. The fate of these micropollutants in the soil is a new and important issue that needs to be known to finally assess the safety of the agricultural use of sewage sludge. The article will discuss issues related to the presence of pharmaceuticals in sewage sludge and their physicochemical properties. The changes that pharmaceuticals undergo have a significant impact on living organisms. This is important for the implementation of a circular economy, which fits perfectly into the agricultural use of stabilized sewage sludge. Research should be undertaken that clearly shows that there is no risk from pharmaceuticals or vice versa: they contribute to the strict definition of maximum allowable concentrations in sludge, which will become an additional criterion in the legislation on municipal sewage sludge.

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Passive Sampling Techniques for Monitoring of Pharmaceuticals and Personal Care Products in Water Matrix: Trends from 2016 to 2020

Nitti

Kapitan

Ola

et al. 2022

Impact of COVID-19 on Emerging Contaminants

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Natural Attenuation of Pharmaceuticals in the Aquatic Environment and Role of Phototransformation

Cited by 11 publications

References 111 publications

A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance

A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance

From Sewage Sludge to the Soil—Transfer of Pharmaceuticals: A Review

Passive Sampling Techniques for Monitoring of Pharmaceuticals and Personal Care Products in Water Matrix: Trends from 2016 to 2020

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