In the past decade, with the rapid development of wearable electronics, medical health monitoring, internet of things and flexible intelligent robots, flexible pressure sensors have received unprecedented attention. As a very important kind of electronic components for information transmission and collection, flexible pressure sensor has gained a wide application prospect in the fields of aerospace, biomedical and health monitoring, electronic skin and human‐machine interface. In recent years, MXene has attracted extensive attention because of its unique two‐dimensional layered structure, high conductivity, rich surface terminal groups and hydrophilicity, which has brought a new breakthrough for flexible sensing. Thus, it has become a revolutionary pressure sensitive material with great potential. In this work, the recent advances of MXene‐based flexible pressure sensors is reviewed from the aspects of sensing type, sensing mechanism, material selection, structural design, preparation strategy and sensing application. The methods and strategies to improve the performance of MXene‐based flexible pressure sensors are analyzed in details. Finally, the opportunities and challenges faced by MXene‐based flexible pressure sensors are discussed. This review will bring the research and development of MXene‐based flexible sensors to a new high level, promoting the wider research exploitation and practical application of MXene materials in flexible pressure sensors.This article is protected by copyright. All rights reserved