Natural Bioactive Compounds from Macroalgae and Microalgae for the
Treatment of Alzheimer’s Disease: A Review

Lee, Jia Yee; Wong, Chiew Yen; Koh, Rhun Yian; Lim, Chooi Ling; Kok, Yih Yih; Chye, Soi Moi

doi:10.59249/jnkb9714

Yale J Biol Med

2024

DOI: 10.59249/jnkb9714

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Natural Bioactive Compounds from Macroalgae and Microalgae for the Treatment of Alzheimer’s Disease: A Review

Jia Yee Lee,

Chiew Yen Wong,

Rhun Yian Koh

et al.

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2024

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Cited by 2 publications

References 161 publications

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Neurodegenerative Marine Algae Bioactive Compounds: A Viable Cure to Treat Amyotrophic Lateral Sclerosis (ALS): A Review

Mani,

Narayanan,

Rajinikanth

2024

Dubai Med J

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Introduction: Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease that causes muscle weakness, paralysis, and death, develops when motor neurons begin to die. There are few proven treatments for ALS, and because the disease is incurable, the exact cause is unknown, making it a devastating condition. According to recent research, marine algae may contain bioactive substances that can be used to treat ALS. Methods: The comprehensive review of recent publications focused on bioactive compounds extracted from various species of marine algae, including their mechanisms of action against oxidative stress, neuroinflammation, and apoptosis in ALS. The publications were reviewed in scientific journals (ScienceDirect, Springer, Taylor & Francis, and MDPI) and indexed in several databases (Scopus, Web of Science, PubMed, Google Scholar, and so on). Discussion: Compounds derived from marine algae, including polyunsaturated fatty acids, fucoxanthin, and polysaccharides, exhibit potential neuroprotective effects by modulating neuroinflammation and oxidative stress levels. Fucoxanthin, fucosterol, and alginate demonstrated potential in mitigating oxidative damage and inflammation, which are critical factors in the pathogenesis of ALS. Conclusion: Bioactive compounds obtained from marine algae demonstrate considerable potential as therapeutic agents for ALS, owing to their capacity to influence multiple pathways linked to oxidative stress and neuroinflammation. Further investigation is required to comprehend their mechanisms and medicinal value, as well as develop novel alternative treatments for ALS.

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Neurodegenerative Marine Algae Bioactive Compounds: A Viable Cure to Treat Amyotrophic Lateral Sclerosis (ALS): A Review

Mani,

Narayanan,

Rajinikanth

2024

Dubai Med J

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Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer’s Disease

Flieger,

Forma,

Flieger

et al. 2024

IJMS

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Alzheimer’s disease (AD) is characterized by, among other things, dementia and a decline in cognitive performance. In AD, dementia has neurodegenerative features and starts with mild cognitive impairment (MCI). Research indicates that apoptosis and neuronal loss occur in AD, in which oxidative stress plays an important role. Therefore, reducing oxidative stress with antioxidants is a natural strategy to prevent and slow down the progression of AD. Carotenoids are natural pigments commonly found in fruits and vegetables. They include lipophilic carotenes, such as lycopene, α- and β-carotenes, and more polar xanthophylls, for example, lutein, zeaxanthin, canthaxanthin, and β-cryptoxanthin. Carotenoids can cross the blood–brain barrier (BBB) and scavenge free radicals, especially singlet oxygen, which helps prevent the peroxidation of lipids abundant in the brain. As a result, carotenoids have neuroprotective potential. Numerous in vivo and in vitro studies, as well as randomized controlled trials, have mostly confirmed that carotenoids can help prevent neurodegeneration and alleviate cognitive impairment in AD. While carotenoids have not been officially approved as an AD therapy, they are indicated in the diet recommended for AD, including the consumption of products rich in carotenoids. This review summarizes the latest research findings supporting the potential use of carotenoids in preventing and alleviating AD symptoms. A literature review suggests that a diet rich in carotenoids should be promoted to avoid cognitive decline in AD. One of the goals of the food industry should be to encourage the enrichment of food products with functional substances, such as carotenoids, which may reduce the risk of neurodegenerative diseases.

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Natural Bioactive Compounds from Macroalgae and Microalgae for the Treatment of Alzheimer’s Disease: A Review

Cited by 2 publications

References 161 publications

Neurodegenerative Marine Algae Bioactive Compounds: A Viable Cure to Treat Amyotrophic Lateral Sclerosis (ALS): A Review

Neurodegenerative Marine Algae Bioactive Compounds: A Viable Cure to Treat Amyotrophic Lateral Sclerosis (ALS): A Review

Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer’s Disease

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