Natural bioactive compounds in Alzheimer's disease: From the perspective of type 3 diabetes mellitus

Huang, Juan; Huang, Nanqu; Mao, Qianhua; Shi, Jingshan; Qiu, Yu

doi:10.3389/fnagi.2023.1130253

Cited by 13 publications

(6 citation statements)

References 85 publications

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“…The impact of glucose homeostasis on brain functions appears to be so meaningful that pathologies such as Alzheimer's Disease (AD) have been defined as Type 3 Diabetes [28][29][30][31]. Peripheral insulin resistance characterising Type 2 Diabetes and excessive adiposity may greatly contribute to the neuroinflammation and insulin resistance observed in the brain by increasing the production of cytotoxic lipids crossing the blood-brain barrier [16].…”

Section: Discussionmentioning

confidence: 99%

Rosmarinic Acid Improves Cognitive Abilities and Glucose Metabolism in Aged C57Bl/6N Mice While Disrupting Lipid Profile in Young Adults in a Sex-Dependent Fashion

Musillo,

Giona,

Ristow

et al. 2023

Nutrients

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A growing body of evidence suggests that regular consumption of natural products might promote healthy aging; however, their mechanisms of action are still unclear. Rosmarinic acid (RA) is a polyphenol holding anti-inflammatory, antioxidant and neuroprotective properties. The aim of this study was to characterise the efficacy of an oral administration of RA in promoting healthspan in a mouse model of physiological aging. Aged C57Bl/6 male and female (24-month-old) mice were either administered with RA (500 mg/Kg) or a vehicle in drinking bottles for 52 days while 3-month-old mice receiving the same treatment were used as controls. All subjects were assessed for cognitive abilities in the Morris water maze (MWM) and for emotionality in the elevated-plus maze test (EPM). Brain-derived Neurotrophic Factor (BDNF) protein levels were evaluated in the hippocampus. Since the interaction between metabolic signals and cerebral functions plays a pivotal role in the etiopathogenesis of cognitive decline, the glycaemic and lipid profiles of the mice were also assessed. RA enhanced learning and memory in 24-month-old mice, an effect that was associated to improved glucose homeostasis. By contrast, the lipid profile was disrupted in young adults. This effect was associated with worse glycaemic control in males and with reduced BDNF levels in females, suggesting powerful sex-dependent effects and raising a note of caution for RA administration in young healthy adult subjects.

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Section: Discussionmentioning

confidence: 99%

Rosmarinic Acid Improves Cognitive Abilities and Glucose Metabolism in Aged C57Bl/6N Mice While Disrupting Lipid Profile in Young Adults in a Sex-Dependent Fashion

Musillo,

Giona,

Ristow

et al. 2023

Nutrients

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“…It is essential to identify drugs with high selectivity, more efficacy, and minimal side effects. Therefore, more randomized double-blind clinical studies are necessary (Huang et al, 2023;Zhou et al, 2024). Although some within the TCM community oppose using this method, arguing that it undermines TCM theory and only verifies the efficacy of the medicine.…”

Section: Theoretical Explanationmentioning

confidence: 99%

Possible opportunities and challenges for traditional Chinese medicine research in 2035

Huang,

et al. 2024

Front. Pharmacol.

Self Cite

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The drug development process is poised for significant transformation due to the rapid advancement of modern biological and information technologies, such as artificial intelligence (AI). As these new technologies and concepts infiltrate every stage of drug development, the efficiency and success rate of research and development are expected to improve substantially. Traditional Chinese medicine (TCM), a time-honored therapeutic system encompassing herbal medicine, acupuncture, and qigong, will also be profoundly impacted by these advancements. Over the next decade, Traditional Chinese medicine research will encounter both opportunities and challenges as it integrates with modern technologies and concepts. By 2035, TCM is anticipated to merge with modern medicine through a more contemporary and open research and development model, providing substantial support for treating a broader spectrum of diseases.

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“…Therefore, the search for new approaches to AD therapy is crucial to address the growing burden of this pathology. Medicinal herbs are a promising avenue for the treatment of AD [ 228 , 229 , 230 , 231 , 232 , 233 ]. Natural compounds were the first therapy used for AD [ 233 ].…”

Section: Natural Compounds As a Novel Treatment For Admentioning

confidence: 99%

Promising Strategies to Reduce the SARS-CoV-2 Amyloid Deposition in the Brain and Prevent COVID-19-Exacerbated Dementia and Alzheimer’s Disease

Navolokin,

Adushkina,

Zlatogorskaya

et al. 2024

Pharmaceuticals

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The COVID-19 pandemic, caused by infection with the SARS-CoV-2 virus, is associated with cognitive impairment and Alzheimer’s disease (AD) progression. Once it enters the brain, the SARS-CoV-2 virus stimulates accumulation of amyloids in the brain that are highly toxic to neural cells. These amyloids may trigger neurological symptoms in COVID-19. The meningeal lymphatic vessels (MLVs) play an important role in removal of toxins and mediate viral drainage from the brain. MLVs are considered a promising target to prevent COVID-19-exacerbated dementia. However, there are limited methods for augmentation of MLV function. This review highlights new discoveries in the field of COVID-19-mediated amyloid accumulation in the brain associated with the neurological symptoms and the development of promising strategies to stimulate clearance of amyloids from the brain through lymphatic and other pathways. These strategies are based on innovative methods of treating brain dysfunction induced by COVID-19 infection, including the use of photobiomodulation, plasmalogens, and medicinal herbs, which offer hope for addressing the challenges posed by the SARS-CoV-2 virus.

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Natural bioactive compounds in Alzheimer's disease: From the perspective of type 3 diabetes mellitus

Cited by 13 publications

References 85 publications

Rosmarinic Acid Improves Cognitive Abilities and Glucose Metabolism in Aged C57Bl/6N Mice While Disrupting Lipid Profile in Young Adults in a Sex-Dependent Fashion

Rosmarinic Acid Improves Cognitive Abilities and Glucose Metabolism in Aged C57Bl/6N Mice While Disrupting Lipid Profile in Young Adults in a Sex-Dependent Fashion

Possible opportunities and challenges for traditional Chinese medicine research in 2035

Promising Strategies to Reduce the SARS-CoV-2 Amyloid Deposition in the Brain and Prevent COVID-19-Exacerbated Dementia and Alzheimer’s Disease

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