Natural biodegradable medical polymers

Fang, Zheng; Wusgal,; Cheng, Hao; Liang, Li

doi:10.1016/b978-0-08-100372-5.00011-8

Cited by 5 publications

(3 citation statements)

References 163 publications

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“…Nisin is readily degraded in the GIT and so has been encapsulated in pectin-based compression coated tablet, giving a controlled-release delivery system [ 9 ]. Encapsulation within delivery systems composed of synthetic polymers, polysaccharides, proteins, liposomes, or inorganic materials improves the immunogenicity, biocompatibility, and stability of peptide therapeutics [ 81 ]. Using biocompatible polymers as delivery systems for AMPs can improve in vivo stability, half-life, and reduce cytotoxicity [ 44 ].…”

Section: Issues Preventing the Application Of Amps As Broad-spectrum ...mentioning

confidence: 99%

Antimicrobial Peptides Demonstrate Activity against Resistant Bacterial Pathogens

Garvey

2023

Infectious Disease Reports

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The antimicrobial resistance crisis is an ongoing major threat to public health safety. Low- and middle-income countries are particularly susceptible to higher fatality rates and the economic impact of antimicrobial resistance (AMR). As an increasing number of pathogens emerge with multi- and pan-drug resistance to last-resort antibiotics, there is an urgent need to provide alternative antibacterial options to mitigate disease transmission, morbidity, and mortality. As identified by the World Health Organization (WHO), critically important pathogens such as Klebsiella and Pseudomonas species are becoming resistant to last-resort antibiotics including colistin while being frequently isolated from clinical cases of infection. Antimicrobial peptides are potent amino acid sequences produced by many life forms from prokaryotic, fungal, plant, to animal species. These peptides have many advantages, including their multi-hit mode of action, potency, and rapid onset of action with low levels of resistance being evident. These innate defense mechanisms also have an immune-stimulating action among other activities in vivo, thus making them ideal therapeutic options. Large-scale production and formulation issues (pharmacokinetics, pharmacodynamics), high cost, and protease instability hinder their mass production and limit their clinical application. This review outlines the potential of these peptides to act as therapeutic agents in the treatment of multidrug-resistant infections considering the mode of action, resistance, and formulation aspects. Clinically relevant Gram-positive and Gram-negative pathogens are highlighted according to the WHO priority pathogen list.

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Section: Issues Preventing the Application Of Amps As Broad-spectrum ...mentioning

confidence: 99%

Antimicrobial Peptides Demonstrate Activity against Resistant Bacterial Pathogens

Garvey

2023

Infectious Disease Reports

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“…This synergistic antimicrobial activity could be explained by two major reactions. First, it is known that the pH affects the solubility of nisin (Fang et al, 2017), with the solubility high at a low pH. At pH 2, nisin solubility is 57 mg/mL and decreases to 1.5 mg/mL at pH 6 (Liu and Hansen, 1990).…”

Section: Screening On Antimicrobial Activity Of Nisin Ascorbic Acid A...mentioning

confidence: 99%

Antimicrobial activity of microencapsulated nisin with ascorbic acid and ethylenediaminetetraacetic acid prepared using double emulsion and freeze-drying technique against Salmonella Enteritidis ATCC 13076 in culture broth and minced fish

2023

ANRES

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Importance of the work: Nisin, a 'generally recognized as safe' natural antimicrobial agent, has poor antimicrobial activity against Gram-negative bacteria and is easily combined with food components. Objectives: To enhance the antimicrobial activity of nisin against Gram-negative bacteria and to prolong its antimicrobial activity using an encapsulating-technique. Materials & Methods: Nisin (N) was combined with ascorbic acid (A) and ethylenediaminetetraacetic acid (EDTA, E) at final concentrations of 500 parts per million (ppm), 2,000 ppm and 250 ppm, respectively. Subsequently, double emulsion and freeze-drying techniques were applied to encapsulate the N-A-E mixture to decelerate their release and prolong their antimicrobial activity in culture broth and a minced fish sample. Results: Besides Gram-positive bacteria, the N-A-E mixture reduced Gram-negative bacteria by 24.74-100%. The obtained microcapsules (MCs) had a smooth surface and spherical morphology with values for moisture content, water activity and production yield of 1.33-5.51%, 0.248-0.402% and 84.00-98.76%, respectively. The MCs prepared using a ratio of maltodextrin-to-gum arabic of 1:1, with a ratio of primary emulsion-to-outer aqueous phase of 1:9 (weight per weight), produced the highest encapsulation efficiency (p < 0.05) of nisin (44.40%). The MCs could completely inhibit Salmonella Enteritidis ATCC 13076 in culture broth (4.85 log CFU/mL) after 4 d of incubation and also exhibited gradual release. In addition, the MCs had an antibacterial effect on minced fish by reducing S. Enteritidis ATCC 13076 by 1.5 log CFU/g after storage at 4 °C for 8 d. Main finding:The N-A-E mixture using an encapsulation approach showed potential as an alternative scheme to address the confined application of nisin in the food industry.

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“…Thus far, four variants of nisin- nisin A, Z, Q and U have been discovered from L. lactis and Streptococcus uberis . 72 Nisin is a polycyclic peptide produced by the process of bacterial fermentation known for its antibacterial activity against a broad range of Gram-positive bacteria including Staphylococcus aureus , and Listeria monocytogenes 73 and has been studied recently as a potential anticancer peptide against colorectal cancer cells. 13 , 16 , 74 The normal physiological function of nisin is to compete with other Gram-positive bacteria for colonisation of cell surfaces and other cellular resources, which contributes to its prevalent use as a safe food preservative in dairy products.…”

Section: Bacteriocinsmentioning

confidence: 99%

The role of key gut microbial metabolites in the development and treatment of cancer

Jaye

Chang

et al. 2022

Gut Microbes

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In recent years, the role of gut microbial metabolites on the inhibition and progression of cancer has gained significant interest in anticancer research. It has been established that the gut microbiome plays a pivotal role in the development, treatment and prognosis of different cancer types which is often mediated through the gut microbial metabolites. For instance, gut microbial metabolites including bacteriocins, short-chain fatty acids and phenylpropanoid-derived metabolites have displayed direct and indirect anticancer activities through different molecular mechanisms. Despite the reported anticancer activity, some gut microbial metabolites including secondary bile acids have exhibited pro-carcinogenic properties. This review draws a critical summary and assessment of the current studies demonstrating the carcinogenic and anticancer activity of gut microbial metabolites and emphasises the need to further investigate the interactions of these metabolites with the immune system as well as the tumour microenvironment in molecular mechanistic and clinical studies.

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Natural biodegradable medical polymers

Cited by 5 publications

References 163 publications

Antimicrobial Peptides Demonstrate Activity against Resistant Bacterial Pathogens

Antimicrobial Peptides Demonstrate Activity against Resistant Bacterial Pathogens

Antimicrobial activity of microencapsulated nisin with ascorbic acid and ethylenediaminetetraacetic acid prepared using double emulsion and freeze-drying technique against Salmonella Enteritidis ATCC 13076 in culture broth and minced fish

The role of key gut microbial metabolites in the development and treatment of cancer

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