Natural biomolecules and derivatives as anticancer immunomodulatory agents

Bernitsa, Stavroula; Dayan, Rotem; Stephanou, Anastasis; Tzvetanova, Iva D.; Patrikios, Ioannis

doi:10.3389/fimmu.2022.1070367

Cited by 8 publications

(3 citation statements)

References 271 publications

(342 reference statements)

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“…Therefore, cancer immunotherapy has recently received considerable attention as a treatment option for certain cancers. Natural plant-derived compounds have been shown to have anti-cancer properties by modulating traditional cancer pathways as well as immunity [52]. Berberine is also beneficial at early stages of tumor development by downregulating the expression of epithelial-mesenchymal transition proteins [2].…”

Section: Discussionmentioning

confidence: 99%

Anticancer properties of berberine - analysis of the latest reports

Rozwadowska,

Bator,

Razik

et al. 2024

J Educ Health Sport

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Introduction and purpose: Berberine is a plant alkaloid that naturally occurs in the fruits of common barberry (Berberis vulgaris). This alkaloid has long been used in natural medicine. It exhibits a range of bioactivities, such as antioxidant, anti-inflammatory, antidiabetic, anti-edema, and antimicrobial actions. Through the promising therapeutic effects of berberine in metabolic syndrome, as well as its impact on carcinogenesis, this compound is beginning to play a significant role in preventive medicine. Recently, particular attention has been paid to the anticancer properties of berberine, which are based on many biochemical pathways, particularly its pro-apoptotic and anti-inflammatory action. The study aimed to review the anticancer mechanisms of berberine and summarize them about individual cancers. State of knowledge: The article reviews the current literature on the anticancer properties of berberine for individual cancers, focusing primarily on its molecular mechanisms of action. In addition, the potential of berberine as a promising candidate forming the basis for drug production and its use in preventive medicine was analyzed. Summary: In summary, many studies have shown that berberine exhibits anticancer activity in many types of cancers, including breast, lung, stomach, liver, colorectal, ovarian, cervical, and prostate cancers. Berberine inhibits the growth of cancer cells, limits metastases, induces apoptosis, stimulates autophagy, and enhances the effectiveness of anticancer drugs. Despite its potential as a promising candidate for drug production, there are currently no approved pure berberine preparations for the treatment of specific ailments. Research on its effectiveness and safety is still ongoing.

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Section: Discussionmentioning

confidence: 99%

Anticancer properties of berberine - analysis of the latest reports

Rozwadowska,

Bator,

Razik

et al. 2024

J Educ Health Sport

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“…A notable statistic underscores the significance of natural origins, indicating that 51% of the 1211 newly approved small-molecule drugs worldwide between 1981 and 2014 were derived from natural products [ 20 ]. Polyphenols have been known to have various preventive effects on different conditions such as diabetes, cardiovascular disease, neurodegenerative disorder, and obesity [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ], and have been extensively studied to determine their anticancer potential and incorporate them into cancer treatment modalities like chemotherapy and targeted therapy [ 30 , 31 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in Nanoparticle Formulations for Resveratrol Encapsulation as an Anticancer Agent

Ali,

Benfante,

Di Raimondo

et al. 2024

Pharmaceuticals

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Resveratrol is a polyphenolic compound that has gained considerable attention in the past decade due to its multifaceted therapeutic potential, including anti-inflammatory and anticancer properties. However, its anticancer efficacy is impeded by low water solubility, dose-limiting toxicity, low bioavailability, and rapid hepatic metabolism. To overcome these hurdles, various nanoparticles such as organic and inorganic nanoparticles, liposomes, polymeric nanoparticles, dendrimers, solid lipid nanoparticles, gold nanoparticles, zinc oxide nanoparticles, zeolitic imidazolate frameworks, carbon nanotubes, bioactive glass nanoparticles, and mesoporous nanoparticles were employed to deliver resveratrol, enhancing its water solubility, bioavailability, and efficacy against various types of cancer. Resveratrol-loaded nanoparticle or resveratrol-conjugated nanoparticle administration exhibits excellent anticancer potency compared to free resveratrol. This review highlights the latest developments in nanoparticle-based delivery systems for resveratrol, focusing on the potential to overcome limitations associated with the compound’s bioavailability and therapeutic effectiveness.

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“…In this Special Issue, nine state-of-the-art and outstanding papers are presented: four original research manuscripts and five literature reviews which provide insights into molecular diagnostics in cancer detection as well as the use of molecular markers for the assessment of tumor response to cancer treatment. In fact, despite the advances in chemotherapy, the persistent issue of the resistance and non-responsiveness of tumors to treatment regimens is still of major concern [ 4 ]. Indeed, the assessment of tumor response to therapy is of critical importance as it permits a prospective end-point evaluation and provides a guide for clinicians to make future treatment decisions.…”

mentioning

confidence: 99%