Natural Cannabinoids as Templates for Sleep Disturbances Treatments

Murillo-Rodrı́guez, Eric; Machado, Sérgio; Imperatori, Claudio; Yamamoto, Tetsuya; Budde, Henning

doi:10.1007/978-3-030-61663-2_9

Cited by 7 publications

(5 citation statements)

References 88 publications

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“…The literature is contradictory with respect to the effect of CBD on sleep in both human and animal studies, as some do not find an effect [22][23][24], some show significant improvements [22][23][24][25][26][27][28][29][30][31], and some show detrimental effects [22,27,[32][33][34]. The data from this study suggest that these differences may be due to the underlying quality of sleep of individuals and the severity of DD.…”

Section: Discussioncontrasting

confidence: 64%

“…The data from this study suggest that these differences may be due to the underlying quality of sleep of individuals and the severity of DD. In humans with anxiety, daily low-dose CBD (25–50 mg/day) improves sleep; in normal individuals, a moderate single dose (300 mg) has no effect on sleep, but chronic administration of a moderate to high dose (600 mg/day) causes drowsiness in 20% [29, 32]. In one study, high-dose CBD use in individuals with epilepsy (10–20 mg/kg) causes drowsiness in 30% of individuals, but a different study found that it improves sleep and reduces DD [22, 27].…”

Section: Discussionmentioning

confidence: 99%

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The Effects of Long-Term Self-Dosing of Cannabidiol on Drowsiness, Testosterone Levels, and Liver Function

Kaufmann¹,

Bozer

Jotte

et al. 2023

Med Cannabis Cannabinoids

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Introduction: Previous research indicated that cannabidiol (CBD) may result in low levels of male total testosterone (TT), elevations in liver tests (LTs), and daytime drowsiness (DD). We investigated the prevalences of TT and LT in a large adult sample self-administering CBD and determined the effect self-dosing of CBD has on the severity of DD. Methods: Adult participants (18–75 years of age) who self-dose CBD orally for a minimum of 30 days were recruited for this decentralized observational study from companies that offer CBD products. Participants were sent their usual CBD regimen. A clinical study platform was used on a phone app to obtain consent and collect study data. Data included demographic information, reasons for self-dosing, dosage, current medications and dosage, medical history, adverse effects, effects on DD, and efficacy. After 30 days, LT and TT were obtained and follow-up LT was offered to participants who demonstrated elevated values of alanine transaminase (ALT). Results: A total of 28,121 individuals were contacted, 1,475 met the criteria and were enrolled, and 1,061 (female: 65.2%, male: 34.8%) completed the study. Most of the participants used full-spectrum CBD oil or CBD isolate with the mean ± SD daily dose of CBD for all users of 55.4 ± 37.8 mg. CBD use was associated with a significant decrease in DD and a decrease in the prevalence of low TT in males >40 years of age. The prevalences of elevations in ALT and aspartate aminotransferase were not significantly different from those of the general adult population, and the prevalences of elevated levels of alkaline phosphatase and bilirubin were less than those of a healthy adult population. There was no relationship between LT and CBD dose. Conclusions: In this large-sample study, self-dosing CBD was not associated with an increased prevalence of elevation of LT or low levels of TT in men. Furthermore, CBD administration decreased DD and was associated with a lower prevalence of low testosterone levels in older men as compared to age-adjusted population norms.

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Section: Discussioncontrasting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

The Effects of Long-Term Self-Dosing of Cannabidiol on Drowsiness, Testosterone Levels, and Liver Function

Kaufmann¹,

Bozer

Jotte

et al. 2023

Med Cannabis Cannabinoids

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“…For Crippa, Zuardi and Hallak (2010, p.62), the "paradoxical findings" of delta 9-THC "could be explained by the observation that its effects on anxiety and mood seem to be dose-dependent", with "low to moderate doses" demonstrating "anxiolytic and euphoric properties", and "higher doses" being "anxiogenic" (SILVA, 2021, p.). Murillo-Rodriguez, Pandi-Perumal, and Monti (2021) contribute to a number of current discussions on psychiatric use in the dossier "Cannabinoids and neuro psychiatric disorders." In the present work we will refer to one of the articles, related to recent advances on the neuroprotective potential of cannabinoids in Alzheimer's (PÉREZ-OLIVES, RIVAS-SANTISTEBAN; LILLO; NAVARRO; FRANCO, 2021).…”

Section: On the Effects And Risks Of The Medicinal Use Of Cannabinoid...mentioning

confidence: 99%

Cannabis & Alzheimer's: From adjunctive use in symptoms to neuromodulatory therapy

Silva¹

2023

Global Health Trends and Perspectives in Health Sciences

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This paper addresses the adjuvant use and neuromodulatory therapy of cannabis in Alzheimer's. It preliminarily considers the effects and risks of the medicinal use of cannabis, the anticonvulsant effect in epilepsy and the prospects for use in Alzheimer's. He argues for neuromodulatory use in Alzheimer's, in addition to the more restricted use to placate symptoms. And it concludes by pointing to the half-open perspectives and more recent investigations about the neuroprotective character of cannabis.

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“…Cannabinoids are present in the industrial hemp plant and their production determines the power of each one to provide well-being [29][30][31][32][33]. They are the cannabinoids of importance for the protection of health, being these associated with Cannabidiol (CBD) and provide protection related to sleep, pain, inflammation, anxiety and seizures [34][35][36][37][38][39][40][41][42][43][44]. In the case of Cannabinol (CBN), it is associated with promotion, since it refers to neuroprotection and appetite stimulation [45][46][47][48][49][50], as well as Cannabigerol (CBG) is related to health promotion, referring to digestive and antibacterial benefits [51][52][53][54].…”

Section: Introductionmentioning

confidence: 99%

Hemp Genotype Selection Coefficient to Improve Human Welfare Development

Santos¹,

Santos²,

Rodríguez³

2023

Proceedings of the 21th LACCEI International Multi-Conference for Engineering, Education and Technology (LACCEI 2023): “Leaders

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The new concept of industrial hemp genetic selection examines the relationship levels of the Human Wellbeing Coefficient (K), and the variables grouped in three dimensions of promotion and protection human health with legality framework. The industrial hemp population was 47 hybrids. Eighteen samples were made for each hybrid during six weeks of evaluation. The Hewlett Packard 1100 HPLC equipment was used to analyze the fresh inflorescence samples during the 2019-2020 agricultural season in Montevideo, Uruguay. The hypothesis test, linear regression analysis, ANOVA, Decision Tree, PCA, HCA and Nearest Neighbor Analysis were used as statistics. The coefficient K has a statistically significant positive correlation with the variable Total Cannabidiols -TCBD (CC = ,978; p <.005). It also with the Total Tetrahydrocannabinols -TTHC variable (CC = ,936; p <.005) and with the Full Protection Projection -R1s variable (CC = ,979; p <.005). It is observed that the K coefficient is negatively correlated with the Coefficient of Promotion -R9. When K values increase, the probability of increasing the promotion and protection of human health is higher (R2=0,99; F(4,841) = 30.974.72; Sig = ,000). Hybrids whose K values >4.82 were selected. From the analysis of PCA and HCA, it has been possible to select the six best hybrids and were grouped into two categories. The first group of superior hybrids. This analysis confirmed the potency of the K Coefficient to select hybrids that contain the highest capacity to promote and protect human health.

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Natural Cannabinoids as Templates for Sleep Disturbances Treatments

Cited by 7 publications

References 88 publications

The Effects of Long-Term Self-Dosing of Cannabidiol on Drowsiness, Testosterone Levels, and Liver Function

The Effects of Long-Term Self-Dosing of Cannabidiol on Drowsiness, Testosterone Levels, and Liver Function

Cannabis & Alzheimer's: From adjunctive use in symptoms to neuromodulatory therapy

Hemp Genotype Selection Coefficient to Improve Human Welfare Development

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