Natural Carbohydrates-based Nanoparticles: A Review of Pharmaceutical
Applications

Kumar, Karan; Wadhwa, Sheetu; Sharma, Arun; Singh, Gurvinder; Kumar, Rajesh

doi:10.2174/2210315512666220826145928

Cited by 2 publications

References 153 publications

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Fabrication and Investigation of Oxidized-β-Cyclodextrin Nanoparticle as a Novel Class pH Responsive Drug Delivery Vehicle

Bergal,

Andac

2023

J Polym Environ

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Oxidized β-cyclodextrin (O-β-CD) nanoparticle was synthesized using oxidation process and Amoxicillin trihydrate (AMOX) model drug was integrated both via Schiff base reaction (C = N bond) as well as inclusion into cavity of O-β-CD to evaluate pH-responsive drug release behavior. The drug loaded nanocarrier (AM-O-β-CD) was characterized and results showed this formation, encapsulation and morphological change with average particle size (398 ± 8.51nm), negative zeta potential values (-25.4 ± 1.54) and high entrapment e ciency (86.1%).The in vitro release behavior of AM-O-β-CD was evaluated in physiological buffer conditions (0.1 M PBS, pH 5.2, at 37°C). It was found that drug-loaded AM-O-β-CD showed sustain, prolonged much higher drug release pro le (94.72%) in low pH than that of the pure drug (24.18%) in the same acidic medium.Release kinetics of drug loaded AM-O-β-CD was determined according to well-known mathematical models, revealing that in vitro release pro le could be best expressed by Higuchi kinetic model as release data showed the highest linearity (R 2 = 0.967) so that drug release takes place due to both dissolution and diffusion as it is expected.As a result, it has been proven that the nanostructure has the potential to be pH sensitive drug carrier, especially for drugs containing NH 2 side groups in acidic environments.

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Fabrication and Investigation of Oxidized-β-Cyclodextrin Nanoparticle as a Novel Class pH Responsive Drug Delivery Vehicle

Bergal,

Andac

2023

J Polym Environ

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show abstract

Fabrication and investigation of oxidized- β- Cyclodextrin nanoparticle as a novel class pH responsive drug delivery vehicle

Bergal,

Andac

2023

Preprint

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Oxidized β- cyclodextrin (O-β-CD) nanoparticle was synthesized using oxidation process and Amoxicillin trihydrate (AMOX) model drug was integrated both via Schiff base reaction (C = N bond) as well as inclusion into cavity of O-β-CD to evaluate pH-responsive drug release behavior. The drug loaded nanocarrier (AM-O-β-CD) was characterized and results showed this formation, encapsulation and morphological change with average particle size (398 ± 8.51nm), negative zeta potential values (-25.4 ± 1.54) and high entrapment efficiency (86.1%). The in vitro release behavior of AM-O-β-CD was evaluated in physiological buffer conditions (0.1 M PBS, pH 5.2, at 37°C). It was found that drug-loaded AM-O-β-CD showed sustain, prolonged much higher drug release profile (94.72%) in low pH than that of the pure drug (24.18%) in the same acidic medium. Release kinetics of drug loaded AM-O-β-CD was determined according to well-known mathematical models, revealing that in vitro release profile could be best expressed by Higuchi kinetic model as release data showed the highest linearity (R2 = 0.967) so that drug release takes place due to both dissolution and diffusion as it is expected. As a result, it has been proven that the nanostructure has the potential to be pH sensitive drug carrier, especially for drugs containing NH2 side groups in acidic environments.

show abstract

Natural Carbohydrates-based Nanoparticles: A Review of Pharmaceutical Applications

Cited by 2 publications

References 153 publications

Fabrication and Investigation of Oxidized-β-Cyclodextrin Nanoparticle as a Novel Class pH Responsive Drug Delivery Vehicle

Fabrication and Investigation of Oxidized-β-Cyclodextrin Nanoparticle as a Novel Class pH Responsive Drug Delivery Vehicle

Fabrication and investigation of oxidized- β- Cyclodextrin nanoparticle as a novel class pH responsive drug delivery vehicle

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