2009
DOI: 10.1038/icb.2008.92
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Natural CD4+ T‐cell responses against Trypanosoma cruzi KMP‐11 protein in chronic chagasic patients

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Cited by 3 publications
(5 citation statements)
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“…The acute phase of the infection is followed by a chronic phase with the presence of a low level parasitemia. CD4þ and CD8þ T lymphocytes participate in the control but not the elimination of T. cruzi, as consistently demonstrated in animal models and human infection [14][15][16]. Approximately 30% of chronically infected individuals become symptomatic due to heart or gastrointestinal involvement [17].…”
Section: Introductionmentioning
confidence: 83%
“…The acute phase of the infection is followed by a chronic phase with the presence of a low level parasitemia. CD4þ and CD8þ T lymphocytes participate in the control but not the elimination of T. cruzi, as consistently demonstrated in animal models and human infection [14][15][16]. Approximately 30% of chronically infected individuals become symptomatic due to heart or gastrointestinal involvement [17].…”
Section: Introductionmentioning
confidence: 83%
“…The description of new class II epitopes is a key contribution of this work, as the study of these cells' specificity in Chagas' disease is far less documented than that of CD8 + T cells. Until the production of this article, T. cruzi proteins known to activate a Th response in Chagas' disease patients were KMP-11 (17), Tc24, and TSA-1 (18). Abel and collaborators (19) had also determined that several variants of a peptide from repetitive Ag B13 are presented to CD4 + T cells in the context of HLA-DQA1*05:01-DQB1*03:01, and some of these variants trigger proliferation specifically in cells from T. cruzi-infected patients.…”
Section: Discussionmentioning
confidence: 99%
“…In particular, cruzipain, kinetoplastid membrane protein 11 (KMP-11), heat shock protein 70 (HSP-70), putative surface Ag TcCA-2, and several members of the trans-sialidase superfamily of proteins have been reported as sources of epitopes recognized by human CD8 + T cells (11)(12)(13)(14)(15). The specificity of T. cruzi-specific CD4 + T cells has been studied to a far lesser extent (16), and only a few proteins (trypomastigote surface Ag 1 [TSA-1], Tc24, Ag B13, and KMP -11) have been demonstrated to induce a recall response on CD4 + T cells cells from chronic patients (17)(18)(19).…”
Section: The Journal Of Immunologymentioning
confidence: 99%
“…Only a few proteins have been demonstrated to induce a recall response on CD4 + T cells from T. cruzi infected-individuals in the chronic phase of the disease ( 38 , 49 , 52 , 76 , 77 ).…”
Section: Cd4 + T Cell Specificity In Chagas Diseasementioning
confidence: 99%
“…Concerning KMP-11, a specific CD4 + T cell response was shown as INF-γ production upon the stimulation of PBMC from chronic Chagas disease patients with the recombinant antigen ( 76 ). KMP-11 responders were mostly patients with severe cardiomyopathy (abnormal ECG and cardiomegaly in chest radiography) whereas only one subject was determined as responder out of eight evaluated donors in patients with normal findings on ECG, or abnormal ECG and no cardiac enlargement ( 76 ).…”
Section: Cd4 + T Cell Specificity In Chagas Diseasementioning
confidence: 99%