Natural Chemopreventive Agents for the Treatment and Prevention of Oral Squamous Cell Carcinoma

Remadevi, Viji; Azeez, Juberiya M.; Vini, Ravindran; Sreeja, Sreeharshan; Sujatha, Anjana Sasikumar; Ismael, Saifudeen

doi:10.1007/978-981-16-5422-0_207

Cited by 1 publication

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“…As a transcription factor in various cell functions, FoxO1 regulates biological processes such as cell proliferation, apoptosis, cell cycle and autophagy. 31,36 Its function in different cancer types remains controversial. [37][38][39][40][41][42][43][44][45] Our study found that FoxO1 serves as an oncogene in OC.…”

Section: Discussionmentioning

confidence: 99%

FoxO1 promotes ovarian cancer by increasing transcription and METTL14‐mediated m⁶A modification of SMC4

Tan,

Wang,

Huang

et al. 2024

Cancer Science

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The transcription factor forkhead box protein O1 (FoxO1) is closely related to the occurrence and development of ovarian cancer (OC), however its role and molecular mechanisms remain unclear. Herein, we found that FoxO1 was highly expressed in clinical samples of OC patients and was significantly correlated with poor prognosis. FoxO1 knockdown inhibited the proliferation of OC cells in vitro and in vivo. ChIP‐seq combined with GEPIA2 and Kaplan–Meier database analysis showed that structural maintenance of chromosome 4 (SMC4) is a downstream target of FoxO1, and FoxO1 promotes SMC4 transcription by binding to its −1400/−1390 bp promoter. The high expression of SMC4 significantly blocked the tumor inhibition effect of FoxO1 knockdown. Furtherly, FoxO1 increased SMC4 mRNA abundance by transcriptionally activating methyltransferase‐like 14 (METTL14) and increasing SMC4 m6A methylation on its coding sequence region. The Cancer Genome Atlas dataset analysis confirmed a significant positive correlation between FoxO1, SMC4, and METTL14 expression in OC. In summary, this study revealed the molecular mechanisms of FoxO1 regulating SMC4 and established a clinical link between the expression of FoxO1/METTL14/SMC4 in the occurrence of OC, thus providing a potential diagnostic target and therapeutic strategy.

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Section: Discussionmentioning

confidence: 99%

FoxO1 promotes ovarian cancer by increasing transcription and METTL14‐mediated m⁶A modification of SMC4

Tan,

Wang,

Huang

et al. 2024

Cancer Science

View full text Add to dashboard Cite

show abstract

Natural Chemopreventive Agents for the Treatment and Prevention of Oral Squamous Cell Carcinoma

Cited by 1 publication

References 44 publications

FoxO1 promotes ovarian cancer by increasing transcription and METTL14‐mediated m⁶A modification of SMC4

FoxO1 promotes ovarian cancer by increasing transcription and METTL14‐mediated m⁶A modification of SMC4

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Natural Chemopreventive Agents for the Treatment and Prevention of Oral Squamous Cell Carcinoma

Cited by 1 publication

References 44 publications

FoxO1 promotes ovarian cancer by increasing transcription and METTL14‐mediated m6A modification of SMC4

FoxO1 promotes ovarian cancer by increasing transcription and METTL14‐mediated m6A modification of SMC4

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FoxO1 promotes ovarian cancer by increasing transcription and METTL14‐mediated m⁶A modification of SMC4

FoxO1 promotes ovarian cancer by increasing transcription and METTL14‐mediated m⁶A modification of SMC4