Natural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases

Abstract

Psychiatric disorders are frequently encountered in many neurological disorders, such as Alzheimer’s and Parkinson diseases along with epilepsy, migraine, essential tremors, and stroke. The most common comorbid diagnoses in neurological diseases are depression and anxiety disorders along with cognitive impairment. Whether the underlying reason is due to common neurochemical mechanisms or loss of previous functioning level, comorbidities are often overlooked. Various treatment options are available, such as pharmacological treatments, cognitive-behavioral therapy, somatic interventions, or electroconvulsive therapy. However oral antidepressant therapy may have some disadvantages, such as interaction with other medications, low tolerability due to side effects, and low efficiency. Natural compounds of plant origin are extensively researched to find a better and safer alternative treatment. Experimental studies have shown that phytochemicals such as alkaloids, terpenes, flavonoids, phenolic acids as well as lipids have significant potential in in vitro and in vivo models of psychiatric disorders. In this review, various efficacy of natural products in in vitro and in vivo studies on neuroprotective and their roles in psychiatric disorders are examined and their neuro-therapeutic potentials are shed light.

A flavone from the ethyl acetate extract of Leea rubra leaves with DNA damage protection and antineoplastic activity

“…Along with the above effect, different studies have reported significant activity of flavonoid derivatives on central nervous system, psychiatric disorder, digestive function, neuroprotection, antimicrobial activity etc. [ 43 , 44 ]. So, further investigations can be made to evaluate such effects of the isolated flavones as source of potential therapy.…”

Effects of Astragalus Polysaccharides on CD8+ Tissue-Resident Memory T Cells in Mice with Herpes Simplex

“…Previous studies have suggested that medicinal herbs and plants have strong potential values for improving human health and preventing and treating diseases, such as inhibiting tumor growth [ 9 , 10 ], relieving central and peripheral pain [ 11 ], antidepression [ 12 ], and preventing and treating neurological disorders [ 13 ], gastrointestinal diseases [ 14 ], viral infections, and even COVID-19 [ 15 ]. Astragalus membranaceus Bunge is a commonly used Chinese medicinal herb and also used as food material with a history of more than 2000 years.…”

Atractylodes chinensis Water Extract Ameliorates Obesity via Promotion of the SIRT1/AMPK Expression in High-Fat Diet-Induced Obese Mice

“…Many studies have shown that natural products, including medicinal plants, have a variety of pharmacological and biological properties and show potential as proper candidates for the treatment of various diseases, such as psychiatric disorders [ 15 ], inflammatory pain disorder [ 16 ], and cancer [ 17 ]. The genus Atractylodes (Asteraceae) is used as a medicinal herb in East Asia [ 18 ].…”