Natural compounds with important medical potential found in Helleborus sp.

Maior, Maria Cornelia; Dobrotă, Cristina

doi:10.2478/s11535-013-0129-x

Cited by 25 publications

(38 citation statements)

References 81 publications

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“…is inserted under the skin of sick animals to treat respiratory problems. The use of Hellborus as an immunostimulating drug has been reported [141,142], but further research is needed for this traditional use. …”

Section: Discussionmentioning

confidence: 99%

Treatment of Organic Livestock with Medicinal Plants: A Systematic Review of European Ethnoveterinary Research

et al. 2014

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Background: The EC Regulation for Organic Farming states that organic livestock should be treated preferably with phytotherapeutic products. In spite of the high importance of organic livestock in Europe, primarily ruminants, today almost no phytotherapeutic product is registered for livestock. Also, information regarding veterinary phytotherapy is rare. The aim of this paper is to find approaches to cope with health problems of organic ruminants in Europe on the basis of findings from the European ethnoveterinary medicine (EuEVM). Methods: A systematic review of ethno-biomedicinal papers was conducted with the aid of the Scopus database, and 75 papers, from European countries were analyzed regarding ethnoveterinary information. Results: A total of 590 plant species referring to 102 different plant families are reported to be used for animal treatment, with Asteraceae, Fabaceae and Lamiaceae being the most important families. The traditional use of some plant species (e.g. mallow, chamomile, wormwood) corresponds with findings from recent scientific literature. The large number of less studied plant species, such as white lupin as an antiparasitic herb, and Helleborus spp. as potential immunostimulatory agent, opens an interesting field for future research. Conclusions: In general, EuEVM provides interesting treatment approaches for gastrointestinal and dermatological disorders as well as parasitosis. Findings regarding disorders of female genital or respiratory tract are less consistent. Nevertheless, EuEVM offers a solid basis for stimulating research in veterinary phytotherapy in Europe with a perspective to solve animal health problems in organic or even nonorganic ruminant production.

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Section: Discussionmentioning

confidence: 99%

Treatment of Organic Livestock with Medicinal Plants: A Systematic Review of European Ethnoveterinary Research

et al. 2014

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“…cardiac glycosides, steroidal saponins, ecdysones, and protoanemonin (Szabó 2005). Steroidal saponins have wide structural diversity as both furostan and spirostan skeleton structures (Challinor et al 2012;Maior and Dobrotȃ 2013). Concentration of helleborin, the most wellknown cardioactive glycoside of hellebores, was found to be higher in H. purpurascens Waldst.…”

Section: Introductionmentioning

confidence: 99%

“…Hellebore species have antioxidant potential (Pȃun-Roman et al 2010;Apetrei et al 2011;Č akar et al 2011), and they can be used for heart failure in human therapy under medical control (Szabó 2005), for various diseases of the immune system (Szabó 2005;Horstmann et al 2008;Littmann et al 2008;Neacşu et al 2010), as antitumoral agents (Vochita et al 2011), for diabetes, eczema, toothache, and arthritis (Maior and Dobrotȃ 2013).…”

Section: Introductionmentioning

confidence: 99%

Ethnobotanical, historical and histological evaluation of Helleborus L. genetic resources used in veterinary and human ethnomedicine

Balázs

Filep

Ambrus

et al. 2020

Genet Resour Crop Evol

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The use of hellebore (Helleborus) species for medical purposes has a long-standing tradition. Our work aimed at providing a historical survey of their medicinal application in Europe, and data on current ethnobotanical use of H. purpurascens Waldst. et Kit. in Transylvania (Romania), compared with earlier records of this region and other European countries. While the chemistry and pharmacology of hellebores have been researched extensively, little is known about their anatomical traits. Thus, we intended to provide a detailed histological analysis of Helleborus odorus Waldst. et Kit., H. purpurascens, and H. niger L., based on transverse sections of aerial parts and root. Our survey revealed that H. purpurascens is known for immunotherapy, wounds, and as antiemetic drug in ethnoveterinary medicine, but not in human therapy in the study area. Distinctive histological characters included diverse stele structure in the root; sclerenchymatous bundle caps around compound vascular bundles in the stem and the main leaf veins of H. odorus; and amphistomatic leaves in H. purpurascens. Quantitative vegetative traits also revealed significant differences among species, but they may reflect environmental influences, too. In all three species the sepal was hypostomatic with mesomorphic stomata, while the modified petal comprised a proximal nectar-producing and a distal non-secretory part. Distinctive floral traits included shape of modified petal, presence of papillae and thickness of nonsecretory part; as well as ornamentation of tricolpate pollen grains. Our findings suggest that the anatomy of various plant parts varies slightly with each species, including ethnomedicinally known H. purpurascens, even though the basic structure is the same within the genus.

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“…The fight against pathogenic bacteria has resulted in an increased use of antimicrobial agents over the years [9,11,17,36,37]. These antimicrobial agents, which include antibacterial nanoparticles, have made it possible to effectively control pathogenic bacteria, especially when used together with other existing methods such as antibiotics [5,28].…”

Section: Introductionmentioning

confidence: 99%

Characterization of flame coated nanoparticle surfaces with antibacterial properties and the heat-induced embedding in thermoplastic-coated paper

et al. 2018

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Silver nanoparticles deposited on surfaces can provide an antibacterial effect with potential uses in, for example, healthcare settings. However, release of nanoparticles and their potential exposure to the environment is of concern. The current work demonstrates a continuous synthesis that simultaneously deposits silver nanoparticles onto plastic coated paper surface by utilizing the liquid flame spray (LFS) aerosol process. Heat from LFS is used to soften the thermoplastic paper surface, which enables partial and full embedding of the nanoparticles, thereby improving adhesion. The embedding is confirmed with atomic force and scanning electron microscopy, and the deposited silver amounts are quantified with X-ray photoelectron spectroscopy. The results suggest that embedding was more effective in PE-coated paper samples due to the lower glass transition temperature when compared to PET-coated paper samples. The antibacterial properties of the surfaces against E. coli and S. aureus were maintained and confirmed with a previously developed 'Touch-Test Method'. The LFS process has the potential to be used for large-scale manufacturing of antibacterial surfaces with improved nanoparticle adhesion on appropriately chosen thermoplastic surfaces.

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Natural compounds with important medical potential found in Helleborus sp.

Cited by 25 publications

References 81 publications

Treatment of Organic Livestock with Medicinal Plants: A Systematic Review of European Ethnoveterinary Research

Treatment of Organic Livestock with Medicinal Plants: A Systematic Review of European Ethnoveterinary Research

Ethnobotanical, historical and histological evaluation of Helleborus L. genetic resources used in veterinary and human ethnomedicine

Characterization of flame coated nanoparticle surfaces with antibacterial properties and the heat-induced embedding in thermoplastic-coated paper

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