The essential oils extracted from Lippia rugosa and Plectranthus glandulosus leaves from Cameroon were analysed by GC-MS and evaluated for their antifungal activities against Aspergillus flavus, Aspergillus niger and Fusarium moniliforme common fungi causing spoilage of stored food product, and antiradical activities. The disc diffusion method was used to evaluate the fungal growth inhibition at various concentrations of oils while the antiradical activity was studied by the DPPH (diphenyl picryl hydrazyl) method. The main components found in P. glandulosus leaves oil were terpinolene (30.8%), fenchone (13.2%), terpene 4-ol (11%) and piperitenone oxyde (8%) whereas L. rugosa leaves oil is mainly constituted of thymol (26.7%), p-cymene (15.5%), thymol acetate (13.2%) and γ-terpinene (9.4%). L. rugosa exhibited the lowest MIC value in liquid medium ranged from 0.2 to 0.3 mg/ml against all fungal strain, and P. glandulosus which was less active with value ranged from 0.8 to 1mg/ml against all fungal strain. The antiradical activity of L. rugosa essential oil (SC 50 = 6.7 g/l) was less than that of butylated hydroxyl toluene (BHT) which was used as the reference compound (SC 50 = 0.007 g/l). Results obtained in the present study indicate the possibility of exploiting these essential oils in the fight against strains of A. flavus, A. niger and Fusarium moniliforme responsible for biodeterioration of stored food products.