Natural course and risk factors for impaired renal function during the first year after heart transplantation

Jokinen, Jukka; Tikkanen, Jussi; Kukkonen, Sinikka; Hämmäinen, Pekka; Lommi, Jyri; Sipponen, J; Lemström, Karl

doi:10.1016/j.healun.2010.01.004

Cited by 36 publications

(30 citation statements)

References 22 publications

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“…Such a release is a well-recognized biochemical marker of preservation effectiveness [22]. Effectiveness of preservation largely relies on surgical procedure, type of cardioplegic solution, and the quality of graft itself, given an intrinsic higher vulnerability for those either hypertrophic, or older, or with unavailable coronary angiograms in presence of multiple risk factors and, of course, the distant ones.…”

Section: Discussionmentioning

confidence: 99%

Implications of acute kidney injury after heart transplantation: what a surgeon should know

Santo¹,

Romano²,

Amarelli³

et al. 2011

European Journal of Cardio-Thoracic Surgery

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Section: Discussionmentioning

confidence: 99%

Implications of acute kidney injury after heart transplantation: what a surgeon should know

Santo¹,

Romano²,

Amarelli³

et al. 2011

European Journal of Cardio-Thoracic Surgery

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“…Future studies are needed to better define predictors of patients who have AKI that will improve after LVAD implantation and to evaluate long-term renal function and survival in DT patients. This information is important given the costs of LVAD implantation, that cardiac transplant eligibility is often dependent on acceptable renal function (often an eGFR $50 ml/min per 1.73 m 2 ) (66,67), and that use of calcineurin inhibitors will cause progressive renal damage in a significant number of heart transplant recipients (64,68). The ability of LVADs to improve comorbidities that are contraindications to cardiac transplantation, such as RD, indicates that another benefit of LVAD placement is as a bridge to candidacy (69,70).…”

Section: Improvement Of Rd After Lvad Placementmentioning

confidence: 99%

Renal Failure in Patients with Left Ventricular Assist Devices

Patel

Adeseun

Ahmed

et al. 2013

Clinical Journal of the American Society of Nephrology

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SummaryImplantable left ventricular assist devices (LVADs) are increasingly being used as a bridge to transplantation or as destination therapy in patients with end stage heart failure refractory to conventional medical therapy. A significant number of these patients have associated renal dysfunction before LVAD implantation, which may improve after LVAD placement due to enhanced perfusion. Other patients develop AKI after implantation. LVAD recipients who develop AKI requiring renal replacement therapy in the hospital or who ultimately require longterm outpatient hemodialysis therapy present management challenges with respect to hemodynamics, volume, and dialysis access. This review discusses the mechanics of a continuous-flow LVAD (the HeartMate II), the effects of continuous blood flow on the kidney, renal outcomes of patients after LVAD implantation, dialysis modality selection, vascular access, hemodynamic monitoring during the dialytic procedure, and other issues relevant to caring for these patients.

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“…The most consistent risk factor for kidney dysfunction in the non-renal organ transplant recipient is the level of renal function prior to transplantation. 3,4 For decades, the primary cause of CKD after solid-organ transplantation has been thought to be calcineurin inhibitor (CNI) toxicity. [5][6][7][8][9][10] CNIs are believed to produce two specific forms of nephrotoxicity: an acute, functional nephrotoxicity and a chronic, structural form.…”

mentioning

confidence: 99%