Natural course of 500 consecutive cases of whooping cough: a general practice population study

Jenkinson, Douglas

doi:10.1136/bmj.310.6975.299

Cited by 57 publications

(19 citation statements)

References 7 publications

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“…11 Although Halperin et al 12 and Jenkinson 13 confirmed this finding, our results and other recent studies 9,14,15 showed an even distribution of pertussis between both genders in children. Data from the CDC revealed that up to the age of 15 years, a similar number of boys and girls (50% to 51%) had pertussis, whereas a female preponderance (55% to 69%) was noted in older age groups.…”

Section: Discussionsupporting

confidence: 71%

Clinical Findings in Bordetella pertussis Infections: Results of a Prospective Multicenter Surveillance Study

et al. 1997

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ABSTRACT. Objective. To study the clinical presentation of culture-confirmed pertussis in children and their contacts with cough illnesses in an outpatient setting.Methodology. In conjunction with a large pertussis vaccine efficacy trial in Germany, a central laboratory to isolate Bordetella species from nasopharyngeal specimens was established in Erlangen in October 1990. Pediatricians in private practices in southern Germany, the Saar region, and Berlin were encouraged to obtain nasopharyngeal specimens and clinical characteristics from patients with cough illnesses >7 days' duration. Bordetella species were isolated by use of calcium alginate swabs, Regan-Lowe agar, and modified Stainer-Scholte broth. Clinical characteristics were determined by initial and follow-up questionnaires.Results. From October 1990 to September 1996, 20 972 specimens were submitted, and B pertussis was isolated in 2592 instances (12.4%). Of the culture-proven cases, 50.7% were female, and the age range was 6 days to 41 years, with a mean and median of 4.3 years and 4.1 years, respectively. The following characteristics were noted. Only 4% of the patients had received pertussis vaccine. Of unvaccinated patients, 90.2% had paroxysmal cough, 78.9% demonstrated whooping, and 53.3% presented with posttussive vomiting; 5.7% had fever >38°C. The duration of cough was <4 weeks in 37.9% and <3 weeks in 17.4%. Leukocytosis and lymphocytosis (values above the age-specific mean) were observed in 71.9% and 75.9% of unvaccinated patients, respectively. The overall complication rate was 5.8%, and pneumonia (29%) was the most frequent complication. In infants <6 months of age, the rate of complications was 23.8%. One death in a 7-month-old infant occurred.Conclusions. Typical symptoms of pertussis were observed in the great majority of patients regardless of age group. However, the duration of cough was surprisingly short in one sixth of the patients. These short illness cases would not be classified as pertussis according to the World Health Organization clinical case definition, which requires >21 days of spasmodic cough. Pediatrics 1997;100(6). URL: http://www.pediatrics.org/cgi/content/ full/100/6/e10; Bordetella pertussis, surveillance, symptoms, white blood cells.

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Section: Discussionsupporting

confidence: 71%

Clinical Findings in Bordetella pertussis Infections: Results of a Prospective Multicenter Surveillance Study

et al. 1997

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“…Complications included pneumonia, rib fracture, inguinal hernia, severe weight loss and others. Similar ®ndings were reported from a general practitioner in the United Kingdom [77].…”

Section: Diseasesupporting

confidence: 68%

“…Moreover, B. pertussis infection may be a cause of sudden infant death, as has been suggested by epidemiological studies [85,109] and also most recently by demonstration of B. pertussis DNA by PCR in the nasopharynx of deceased infants [66]. In recent years, the fact that pertussis in adolescents and adults is often the source from which infants and children become infected, has received increased attention again [4,16,33,35,52,77,101,108,112,149,150]. However, despite suggestive symptoms, pertussis is frequently not suspected in these age groups and rather``upper respiratory tract infection'' or``bronchitis'' are diagnosed by many primary care providers [100,124].…”

Section: Diseasementioning

confidence: 99%

Recent progress in clinical and basic pertussis research

Heininger¹

2001

Eur J Pediatr

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“…This is in agreement with the findings of Wright et al [2] and Mink et al [3], who concluded that illnesses of patients with pertussis were similar to the illnesses of patients without pertussis. However, in previous studies the diagnosis of B. pertussis infection has for some patients been based on history alone [28,29]. Our study and the studies of Wright et al [2] and Mink et al [3] indicate that the diagnosis of B. pertussis infection should not be based on history alone and that a diagnostic method is needed, at least for adults.…”

Section: Discussioncontrasting

confidence: 50%

Bordetella pertussis and Chronic Cough in Adults

Birkebæk

Kristiansen²,

Seefeldt

et al. 1999

Clinical Infectious Diseases

118

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To evaluate Bordetella pertussis as a cause of persistent cough in adults, we examined 201 patients who had a cough for 2-12 weeks and no pulmonary disease. We obtained the following at presentation: medical history, chest radiograph, respiratory function measurement, nasopharyngeal aspirate for polymerase chain reaction (PCR), nasopharyngeal swab specimen for culture, and a blood sample (acute serum). Four weeks later a second blood sample (convalescent serum) was obtained. Control sera were obtained from 164 age-matched healthy blood donors with no history of cough during the previous 12 weeks. Four patients were B. pertussis culture-positive; 11 (including the culture-positive patients) were B. pertussis PCR-positive; and 33, including 10 of the 11 PCR-positive patients, had serological evidence of recent B. pertussis infection. Pertussis-positive and -negative patients could not be discriminated by a history of cough. We conclude that B. pertussis infection is a common cause of persistent cough in adults. This is of concern, because these patients may be B. pertussis reservoirs from which transmission may occur to infants, in whom the disease can be devastating.

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Natural course of 500 consecutive cases of whooping cough: a general practice population study

Abstract: Objective-To describe the natural course of whooping cough.

Cited by 57 publications

References 7 publications

Clinical Findings in Bordetella pertussis Infections: Results of a Prospective Multicenter Surveillance Study

Clinical Findings in Bordetella pertussis Infections: Results of a Prospective Multicenter Surveillance Study

Recent progress in clinical and basic pertussis research

Bordetella pertussis and Chronic Cough in Adults

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