Natural Course of Cow's Milk Allergy in Children with Atopic Dermatitis

Suh, Jungmin; Lee, Hyeonyoung; Lee, Jung Hyun; Cho, Joongbum; Yu, Jung-Seok; Kim, Jihyun; Han, Youngshin; Ahn, Kangmo; S, Lee

doi:10.3346/jkms.2011.26.9.1152

Cited by 17 publications

(15 citation statements)

References 17 publications

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“…Similar to our result, several studies found a relationship between atopic dermatitis and intolerance to cow's milk in CMA infants and children; however, moderate to severe type of atopic dermatitis was associated with a lower likelihood of developing tolerance (15,16). History of sensitization to certain foods such as egg has been reported with a worse prognosis in early life, but no significant association with intolerance to cow's milk was observed in this study (9).…”

Section: Discussionsupporting

confidence: 86%

“…A large cohort of 512 infants and children with CMA ranging from 3 to 15 months of age at 5 areas of the USA demonstrated a resolution rate of about 50% by age 5 (15). A natural course of CMA in 115 Korean children < 24 months of age with atopic dermatitis showed 50% tolerance at 67 months of age (16). It is, therefore, nearly similar with other studies although the study design, age of infants and children, unselected group of children with immediate type CMA, and the time of follow up were different.…”

Section: Discussionmentioning

confidence: 99%

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IgE-Mediated Cow’s Milk Allergy in Iranian Infants and Children: Predictive Factors of Early Tolerance

2018

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Background: The majority of infants and children with cow's milk allergy will grow out of their allergy after a few years. The aim of this study was to identify the natural course of cow's milk allergy in infants and children during a follow-up of 18 months and also the predictive factors for its outgrowing. Methods: This prospective cross-sectional study included infants and children with IgE-mediated cow's milk allergy. Demographic data, clinical manifestations and probable predictive factors were recorded. Skin prick tests were done with commercial extracts of cow's milk, egg, fish, nuts and wheat on arrival. These infants and children were followed for 18 months and resolution was established by successful ingestion of cow's milk. The collected data were analyzed using SPSS version 22.0. Descriptive statistics, student's t-test or Mann-Whitney U-test and Chi-square test were used; a P < 0.05 was considered statistically significant. Results: Forty-nine infants and children (33 boys and 16 girls) with IgE-mediated cow's milk allergy presentation ranged in age from

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

IgE-Mediated Cow’s Milk Allergy in Iranian Infants and Children: Predictive Factors of Early Tolerance

2018

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“…Different factors seem to have the potential to influence the immune tolerance acquisition. Among these, the most relevant are the following: family history of allergy (FHA) [9], total serum IgE levels, specific IgE to particular cow’s milk protein (CMP) epitopes [7, 10], and the presence of atopic dermatitis [10, 11]. The relevance of gut microbiota in allergic sensitization and food tolerance processes has been highlighted in recent years [12].…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with the Development of Immune Tolerance in Children with Cow’s Milk Allergy

Sánchez-Valverde

Etayo

Gil

et al. 2019

Int Arch Allergy Immunol

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Introduction: Cow’s milk allergy (CMA) is a common diagnosis in infants, requiring the exclusion of cow’s milk until tolerance is recovered. In the present study, we aim to determine which factors are associated with the development of tolerance. Methods: Retrospective, observational study of subjects who underwent the same clinical follow-up methodology. We studied 245 cases of CMA (125 IgE-mediated and 120 non-IgE-mediated). The following variables were analysed: age at diagnosis, gender, type of delivery, type of feeding received, feeding during the first months of life, clinical features, and type of feed received as treatment: casein hydrolysates or casein hydrolysates with Lactobacillus rhamnosus GG (LGG). Results: Factors associated with earlier tolerance were non-IgE-mediated CMA (HR = 2.92; 95% CI: 2.20–3.88) and patients receiving casein hydrolysate with LGG (HR = 1.79; 95% CI: 1.33–2.42). Later tolerance was associated with caesarean delivery (HR = 0.78; 95% CI: 0.58–1.05) and breastfeeding for a period of at least 3 days (HR = 0.64; 95% CI: 0.44–0.93). The multivariate study shows that the type of formula (HR = 1.61; 95% CI: 1.19–2.18) and the type of CMA (HR = 2.82; 95% CI: 2.12–3.85) have an effect on the recovery time. Casein hydrolysates with LGG reduces the recovery time in IgE-mediated (HR = 1.88; 95% CI: 1.17–3.01) and non-IgE-mediated CMA (HR = 1.46; 95% CI: 0.98–2.17). Conclusions: Tolerance acquisition is faster in non-IgE-mediated CMA subjects and in those who received casein hydrolysate with LGG.

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“…In Singapore, at least one first-degree family member with atopy was noted in 70% of children with AD [3]. Additionally, studies from various countries report that approximately one third of children with AD had a diagnosis of allergy or intolerance to cow's milk and, conversely, up to 50% of infants with allergy or intolerance to cow's milk had AD [16,17]. Although the World Health Organization (WHO) recommends exclusive breastfeeding through the first 6 months of life [18,19], this recommendation is not always followed.…”

Section: Introductionmentioning

confidence: 99%

Cost-Effectiveness of Partially Hydrolyzed Whey Protein Formula in the Primary Prevention of Atopic Dermatitis in High-Risk Urban Infants in Southeast Asia

Botteman

Detzel

2015

Ann Nutr Metab

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Background: Atopic dermatitis (AD) is one of the most common skin conditions among infants. Proteins found in cow's milk formula (CMF) have been found to be attributable to heightened AD risk, particularly in infants with familial AD heredity. Previous studies have suggested that intervention with partially hydrolyzed formula in nonexclusively breastfed infants can have a protective effect against AD development. Objective: The aim of the present study was to compare the estimates of the economic impact of reducing the AD incidence by feeding a partially hydrolyzed whey-based formula (PHF-W) instead of a standard CMF to high-risk nonexclusively breastfed urban infants for the first 17 weeks of life in the Philippines, Malaysia, and Singapore. Methods: In each country, a mathematical model simulated AD incidence and burden from birth to 6 years of age of using PHF-W versus CMF in the target population using data from the German Infant Nutritional Intervention study. The models integrated literature, current cost and market data, and expert clinician opinion. Modeled outcomes included AD risk reduction, time spent after AD diagnosis, AD symptom-free days, quality-adjusted life years (QALYs), and costs (direct and indirect). Outcomes were discounted at 3% per year. Costs were expressed in USD. Results: Feeding high-risk infants PHF-W instead of CMF resulted in an estimated absolute 14% (95% CI 1-24) AD risk reduction, a 0.69-year (95% CI 0.25-1.13) reduction in the time spent after AD diagnosis per child, reductions of 16-38 AD days, and gains in 0.02-0.04 QALYs, depending on the country. The per-child AD-related 6-year cost-saving estimates of feeding high-risk infants with PHF-W versus CMF were USD 739 in Singapore, USD 372 in Malaysia, and USD 237 in the Philippines.

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Natural Course of Cow's Milk Allergy in Children with Atopic Dermatitis

Cited by 17 publications

References 17 publications

IgE-Mediated Cow’s Milk Allergy in Iranian Infants and Children: Predictive Factors of Early Tolerance

IgE-Mediated Cow’s Milk Allergy in Iranian Infants and Children: Predictive Factors of Early Tolerance

Factors Associated with the Development of Immune Tolerance in Children with Cow’s Milk Allergy

Cost-Effectiveness of Partially Hydrolyzed Whey Protein Formula in the Primary Prevention of Atopic Dermatitis in High-Risk Urban Infants in Southeast Asia

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