Natural course of diabetic peripheral neuropathy in spontaneous-onset diabetic Chinese hamsters

Hirano, Fuminori; Tanaka, Hirotoshi; Okamoto, Kensaku; Makino, Yuichi; Inaba, Mamoru; Nomura, Yoshinobu; Fukawa, Etsushi; Miura, Takanori; Tani, Takako; Makino, Isao

doi:10.1016/0168-8227(95)01091-q

Cited by 6 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Gas chromatography has been used to establish that the scyllo-inositol content of the sciatic nerve in spontaneousonset diabetic Chinese hamsters is reduced at five months of age and onwards,when compared with healthy equivalents. [77] scyllo-Inositol levels in the frontal or occipital cortex of unipolar,b ipolar,a nd schizophrenic patients,suicide victims, and normal controls do not differ. [78] Intracellular scyllo-inositol levels in rat brain extracts have been analyzed by micellar electrokinetic chromatography.…”

Section: Scyllo-inositol and Diagnosticsmentioning

confidence: 85%

ChemInform Abstract: The “Other” Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo‐Inositol Chemistry)

2016

View full text Add to dashboard Cite

show abstract

Section: Scyllo-inositol and Diagnosticsmentioning

confidence: 85%

ChemInform Abstract: The “Other” Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo‐Inositol Chemistry)

2016

View full text Add to dashboard Cite

show abstract

“…Several animal models of diabetic neuropathy have been developed which include streptozotocin-induced (STZ-induced) diabetic rats,[2425] STZ-induced diabetic mice,[26–27] Chinese hamsters[28] and Otsuka Long-Evans Tokushima Fatty (OLETF) rats. [2930] Each has been used appropriately to address specific questions because of their part pathological resemblance to humans, their amenability to genetic manipulation and/or generation of transgenic animals.…”

Section: Introductionmentioning

confidence: 99%

A brief review ofin vitromodels of diabetic neuropathy

Hattangady¹,

Rajadhyaksha²

2009

Int J Diab Dev Ctries

View full text Add to dashboard Cite

The neuropathies of the peripheral, central and autonomic nervous systems are known to be caused by hyperglycemia, a consequence of the deregulation of glucose in diabetes. Several in vivo models such as streptozotocin-induced diabetic rats, mice and Chinese hamsters have been used to study the pathogenesis of diabetic neuropathy because of their resemblance to human pathology. However, these in vivo models have met with strong ethical oppositions. Further, the system complexity has inherent limitations of inconvenience of analyzing ephemeral molecular events and crosstalk of signal transduction pathways. Alternative in vitro models have been selected and put to effective use in diabetic studies. We critically review the use of these in vitro models such as primary cultures of dorsal root ganglia, Schwann cells and neural tissue as well as neural cell lines which have proved to be excellent systems for detailed study. We also assess the use of embryo cultures for the study of hyperglycemic effects on development, especially of the nervous system. These systems function as useful models to scrutinize the molecular events underlying hyperglycemia-induced stress in neuronal systems and have been very effectively used for the same. This comprehensive overview of advantages and disadvantages of in vitro systems that are currently in use will be of interest especially for comparative assessment of results and for appropriate choice of models for experiments in diabetic neuropathy.

show abstract

“…[77] scyllo-Inositol levels in the frontal or occipital cortex of unipolar, bipolar and schizophrenic patients, suicide victims and normal controls do not differ. [78] Intracellular scyllo-inositol levels in rat brain extracts have been analysed by micellar electrokinetic chromatography.…”

Section: Scyllo-inositol and Diagnosticsmentioning

confidence: 81%

“…Gas chromatography has been used to establish that the scyllo‐ inositol content of the sciatic nerve in spontaneous‐onset diabetic Chinese hamsters is reduced at five months of age and onwards, when compared with healthy equivalents . scyllo ‐Inositol levels in the frontal or occipital cortex of unipolar, bipolar, and schizophrenic patients, suicide victims, and normal controls do not differ .…”

Section: Scyllo‐inositolmentioning

confidence: 99%

The “Other” Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances inmyo‐Inositol Chemistry)

2015

View full text Add to dashboard Cite

Cell signalling via inositol phosphates, eg the second messenger myo-inositol 1,4,5-trisphosphate, and phosphoinositides comprises a huge field of biology. Of nine 1,2,3,4,5,6-cyclohexanehexol isomers, myo-inositol is pre-eminent, with "other" inositols (cis-, epi-, allo-, muco-, neo-, L-chiro-, D-chiro-and scyllo-) and derivatives rarer or thought not to exist in nature. However, recently, neoand D-chiro-inositol hexakisphosphates were revealed in both terrestrial and aquatic ecosystems, highlighting the paucity of knowledge of the origins and potential biological functions of such stereoisomers, a prevalent group of environmental organic phosphates, and their parent inositols. Some "other" inositols are medically relevant, e.g. scyllo-inositol (neurodegenerative diseases), and D-chiro-inositol (diabetes). It is timely to consider exploration of roles and applications of "other" isomers and their derivatives, likely by exploiting techniques now well developed for the myo-series.

show abstract

Natural course of diabetic peripheral neuropathy in spontaneous-onset diabetic Chinese hamsters

Cited by 6 publications

References 29 publications

ChemInform Abstract: The “Other” Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo‐Inositol Chemistry)

ChemInform Abstract: The “Other” Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo‐Inositol Chemistry)

A brief review ofin vitromodels of diabetic neuropathy

The “Other” Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances inmyo‐Inositol Chemistry)

Contact Info

Product

Resources

About