Natural Course of Inoperable Lung Cancer

Hyde, Leroy; Wolf, Julius; McCracken, Stewart; Yesner, Raymond

doi:10.1378/chest.64.3.309

Cited by 97 publications

(28 citation statements)

References 18 publications

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“…A score of 30% indicates that the individual is severely disabled and needs to be hospitalized. The KPS has well-established inter-rater reliability, concurrent validity, and criterion validity (Hyde 1973; Karnofsky 1977). Clinical trial studies have demonstrated that pretreatment performance by Karnofsky rating is a good predictor of response to cancer treatment (Dodd 1988).…”

Section: Methodsmentioning

confidence: 99%

The effect of symptom clusters on functional status and quality of life in women with breast cancer

Dodd

Cho

Cooper

et al. 2010

European Journal of Oncology Nursing

269

280

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Purpose The purposes of this study of women with breast cancer receiving chemotherapy with/without radiation therapy were to determine whether: 1) subgroups of oncology outpatients can be identified based on a specific symptom cluster (i.e., pain, fatigue, sleep disturbances, depression); 2) these subgroups differ on outcomes (i.e., functional status, quality of life; 3) subgroup membership changes over time. Methods A secondary data analysis using data collected from 112 women at initial chemotherapy. Symptom and outcome measures were completed at three time points: baseline (i.e., the week before cycle two - T1); end of cancer treatment (T2), end of the study (approximately one year after the start of chemotherapy - T3). Cluster analysis identified patient subgroups based on symptom severity scores. Results At T1 and T2, four patient subgroups were identified: ALL LOW (one or no symptom greater than the cut score), MILD (two symptoms), MODERATE (three or four symptoms), and ALL HIGH (four symptoms). At T3, three subgroups were identified: MILD, MODERATE and ALL HIGH. Subgroups with high severity levels of all four symptoms had poorer functional status and QOL at each time point than other subgroups (p<.001). Group membership changed over time. Conclusions Subgroups of patients with different symptom experiences were identified. For some patients severity of all four symptoms persisted months after cancer treatment. Initial and ongoing assessment to identify those patients in the ALL HIGH patient subgroup is important so that appropriate interventions to improve functional status and quality of life can be offered.

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Section: Methodsmentioning

confidence: 99%

The effect of symptom clusters on functional status and quality of life in women with breast cancer

Dodd

Cho

Cooper

et al. 2010

European Journal of Oncology Nursing

269

280

View full text Add to dashboard Cite

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“…Considering the five years survival rates, the natural history of lung cancer is unfavorable even in operable cases [28]. Whether immunological mechanisms are involved in the early dissemination of the disease is not quite clear as yet.…”

Section: Discussionmentioning

confidence: 99%

“…At the end of the treatment period, when the patient was dis missed from the hospital, and readmission at 8 week intervals, a complete in vivo and in vitro immunological investigation with the above mentioned methods was performed. By this subsequent evaluation of the patients' immune status under therapy, an immune profile which reflects the influence of the therapy on the immune system is obtained [28]. Changes in the immune reactivity in patients under therapy were evaluated according to Student-T-test.…”

Section: Immunological In Vestigationsmentioning

confidence: 99%

Stimulation of Immune Response in Lung Cancer Patients by Vitamin A Therapy

et al. 1977

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Based on a clinical trial, in which patients with unresectable bronchogenic cancer were treated with a combination of vitamin A plus chemotherapy, or vitamin A plus radiotherapy, a study was initiated in which vitamin A alone was given for tumor treatment. 9 male patients with metastatic unresectable squamous cell carcinoma of the lung were treated with vitamin A palmitate or 13-cis vitamin A acid. Up to seven treatment courses were given during a period of 60 weeks. Through weekly evaluation of the patients’ immune status, an immune potentiating effect of the vitamin A therapy could be demonstrated. An increase of lymphocyte blastogenesis response to PHA which is significant (p < 0.001) compared with the pretreatment values, was found in all patients at the end of one vitamin A treatment course. Increased delayed cutaneous hypersensitivity reactions were observed also in all patients. The immune potentiating effects of vitamin A therapy, as well as the demonstrated direct effect on the tumor, introduces a wide range of combination therapies.

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“…12 However, optimal time-dose relationships for radiotherapy of lung cancer have not been defined. Perez has recently stated that doses of 5500 to 6500 rads in 6-7 weeks are potentially curative in patients with disease limited to the thorax, but observed that delivering doses of this magnitude requires ingenuity on the part of the radiation therapist and the radiation physicist, to avoid excessive irradiation of surrounding normal tissues, such as, the lungs, heart and spinal cord.…”

Section: Optimal Radiation Schedulementioning

confidence: 99%

Radical radiation therapy of advanced lung cancer. Evaluation of prognostic factors and results of continuous and split course treatment

Emami

Munzenrider

Lee

et al. 1979

Cancer

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One hundred patients with inoperable (80) or unresectable (20) bronchogenic carcinoma without evidence of spread beyond the thorax and supraclavicular nodes were planned for radical radiotherapy. Seventy-six patients received continuous irradiation (6000 rads in 30 treatments in 6 weeks, TDF 99) and 24 received split course therapy (2 courses of 2500 rads in 10 treatments with a 3 week break between courses, TDF 88). Forty-three patients had squamous cell carcinoma or adenocarcinoma and were considered to have favorable prognostic factors, while 57 patients had unfavorable prognostic factors: undifferentiated large cell or small cell carcinoma, supraclavicular metastases, SVC obstruction, superior sulcus tumors, or bone erosion in continuity with the tumor.Ninety-two patients completed the planned course of treatment. In patients completing treatment, local control of cancer within the irradiated volume was achieved in 58.5% of continuously irradiated patients and 45.4% of patients receiving split course therapy.Median survival was 1.2 months in patients not completing treatment and 12 months for the patients who completed treatment; 19% of the total group survived 3 years. Median and 3 year survivals of 14 months and 20.4% and of 9 months and 11% were observed for patients treated continuously and by the split course techniques, respectively. Corresponding survival figures for patients with favorable and unfavorable prognostic signs were 21 months and 26%, and 4 months and 11%, respectively.Implications of these data for treatment planning and patient selection for radical radiotherapy in bronchogenic carcinoma are discussed.Cancer 44:446-456, 1979.UNG CANCER HAS BEEN identified as a L current major priority in health care in both the United States and the An estimated 98,000 new cases occurred in the

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Natural Course of Inoperable Lung Cancer

Cited by 97 publications

References 18 publications

The effect of symptom clusters on functional status and quality of life in women with breast cancer

The effect of symptom clusters on functional status and quality of life in women with breast cancer

Stimulation of Immune Response in Lung Cancer Patients by Vitamin A Therapy

Radical radiation therapy of advanced lung cancer. Evaluation of prognostic factors and results of continuous and split course treatment

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