Natural course of lid wiper epitheliopathy (LWE) in symptomatic contact lens wearers

Lievens, Christopher; Norgett, Yvonne; Briggs, Nancy; Allen, Peter M.; Vianya-Estopà, Marta

doi:10.1016/j.clae.2021.101529

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…17 Although the prevalence of LWE is not well established in the literature, it has been estimated that up to 85% of patients with dry eye disease are affected, and it is more common in young people and in people who wear contact lenses. 18 SLK is an inflammatory ocular surface disease with superior limbus and superior bulbar conjunctiva that oculoplastic surgeons should be aware of. 19,20 We hypothesized that IB surgery may affect eyelid friction, thereby influencing the development of LWE and SLK.…”

Section: Discussionmentioning

confidence: 99%

“…However, excessive friction with the cornea can cause LWE and lead to chronic ocular discomfort, including foreign body sensation 17 . Although the prevalence of LWE is not well established in the literature, it has been estimated that up to 85% of patients with dry eye disease are affected, and it is more common in young people and in people who wear contact lenses 18 . SLK is an inflammatory ocular surface disease with superior limbus and superior bulbar conjunctiva that oculoplastic surgeons should be aware of 19,20 .…”

Section: Discussionmentioning

confidence: 99%

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Conjunctival Chalasis Should Not be Overlooked: Investigation Into Postoperative Ocular Surface Changes in Involutional Blepharoptosis

Uemura,

Hiroki,

Saika

et al. 2024

Journal of Craniofacial Surgery

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Background: Involutional blepharoptosis is common among elderly people. The tightening of eyelids postptosis surgery could potentially increase friction between the eyelid and the ocular surface, but this hypothesis has not yet been substantiated by research. The authors explored the relationship between involutional blepharoptosis surgery and friction-related diseases, namely conjunctivochalasis, lid wiper epitheliopathy, and superior limbic keratoconjunctivitis. Methods: We conducted a prospective study involving 31 patients who underwent levator advancement for involutional blepharoptosis. Both preoperatively and 6 weeks postoperatively, the authors assessed a range of outcome measures, including margin reflex distance-1, 2, tear film break-up time, superficial punctate keratopathy, inferior conjunctivochalasis, upper lid wiper epitheliopathy, and superior limbic keratoconjunctivitis Results: Conjunctivochalasis was detected in 18 eyes preoperatively and 20 eyes postoperatively. Lid wiper epitheliopathy was detected in 2 eyes preoperatively and in no eyes postoperatively. Superior limbic keratoconjunctivitis was detected in 2 eyes preoperatively and 1 eye postoperatively. From preoperative to postoperative assessments, conjunctivochalasis worsened in 11 eyes (17.2%), and there were no eyes with worsening lid wiper epitheliopathy or superior limbic keratoconjunctivitis. There was a significant worsening of superficial punctate keratopathy in the group with exacerbated conjunctivochalasis compared with the unchanged group (0.72 vs. 0.12, P=0.0222). The superficial petechial keratopathy in the 6 cases in which there was worsening of both conjunctivochalasis and superficial petechial keratopathy were all located inferiorly in the cornea. Conclusions: Conjunctivochalasis can worsen following ptosis surgery, potentially leading to an increase in inferior superficial punctate keratopathy. When performing involutional blepharoptosis surgery, surgeons should be mindful of the potential implications of friction-related diseases, particularly conjunctivochalasis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Conjunctival Chalasis Should Not be Overlooked: Investigation Into Postoperative Ocular Surface Changes in Involutional Blepharoptosis

Uemura,

Hiroki,

Saika

et al. 2024

Journal of Craniofacial Surgery

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“…Lid wiper epitheliopathy (LWE) is de ned as damage to the epithelium of the lid wiper, primarily caused by insu cient lubrication of the ocular surface for various reasons (such as inadequate interface lubrication, uneven corneoconjunctival surface, abnormal blinking pattern, and frequency), leading to increased friction between the lid wiper and the ocular surface [8][9][10] . This indicates that LWE may be a potential factor contributing to the uneven distribution of CET, and this aspect has been consistently overlooked in previous studies [11][12][13] .…”

Section: Introductionmentioning

confidence: 87%

Effect of Lid-Wiper Epitheliopathy on the Corneal Epithelial Thickness Distribution: A Novel Semiautomatic Quantitative Method

Ye,

Lin,

Lin

et al. 2024

Preprint

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Purpose To explore a novel semi-automatic quantitative method for detecting lid-wiper epitheliopathy (LWE) and analyze its impact on the distribution of corneal epithelial thickness (CET). Methods A total of 36 eyes from 36 adults were included in this study. The lid wipers were stained with lissamine green strips, and the stained areas were recorded using a digital slit-lamp biomicroscopy and analyzed using ImageJ software. Factors such as age, sex, and refraction were included as variables that influenced LWE. The CET was divided into 25 regions and recorded using spectral-domain optical coherence tomography. Results Methodological consistency and repeatability were verified through intra- and inter-operator intraclass correlation coefficients (ICCs), with values of 0.889 and 0.922, respectively. After adjusting for age, sex, and spherical equivalent refraction (SER), a negative correlation was observed between LWE and epithelial thickness. Specifically, negative correlations were observed in the nasal, subnasal, and inferior regions within the 2–5 mm range; subnasal and infratemporal regions within the 5–7 mm range; and the infratemporal region within the 7–9 mm range. Conclusion This study validated a novel method for assessing the severity of LWE by quantitatively analyzing the LWE area. Additionally, LWE is associated with thinning of the inferior corneal epithelium.

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The R-evolution of contact lenses: Will long-term contact lens wearers in the future be the same as now?

Carnt

González-García

2022

Contact Lens and Anterior Eye

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Natural course of lid wiper epitheliopathy (LWE) in symptomatic contact lens wearers

Cited by 4 publications

References 30 publications

Conjunctival Chalasis Should Not be Overlooked: Investigation Into Postoperative Ocular Surface Changes in Involutional Blepharoptosis

Conjunctival Chalasis Should Not be Overlooked: Investigation Into Postoperative Ocular Surface Changes in Involutional Blepharoptosis

Effect of Lid-Wiper Epitheliopathy on the Corneal Epithelial Thickness Distribution: A Novel Semiautomatic Quantitative Method

The R-evolution of contact lenses: Will long-term contact lens wearers in the future be the same as now?

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