This paper develops systematically the stochastic calculus via regularization in the case of jump processes. In particular one continues the analysis of real-valued càdlàg weak Dirichlet processes with respect to a given filtration. Such a process is the sum of a local martingale and an adapted process A such that [N, A] = 0, for any continuous local martingale N . Given a function u : [0, T ] × R → R, which is of class C 0,1 (or sometimes less), we provide a chain rule type expansion for u(t, X t ) which stands in applications for a chain Itô type rule.