Natural Decrease of Benign Metastasizing Leiomyoma

Arai, Tadashi; Yasuda, Yo; Takaya, Tomofumi; Shibayama, M

doi:10.1378/chest.117.3.921

Cited by 52 publications

(40 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A combination of medical and surgical treatment would exert a synergistic effect and should be considered in the management of progressive and symptomatic lesions. One previous study proposed that BML may naturally decrease following the menopause (27). The majority of BML lesions remain at one size, however, a small percentage display an aggressive course (28).…”

Section: Discussionmentioning

confidence: 99%

Benign metastasizing leiomyoma of the lung: A case report and literature review

Wei

Chen

2015

Oncology Letters

View full text Add to dashboard Cite

Abstract. Pulmonary benign metastasizing leiomyoma (BML) is a rare event characterized by benign soft-tissue tumors that occur when uterine leiomyomas metastasize to the lung. The present study reports the case of a 47-year-old female patient who presented with multiple bilateral pulmonary nodules on a chest X-ray during a health checkup nine years after a hysterectomy due to uterine fibroids. Chest computed tomography (CT) revealed multiple well-defined nodular shadows in the lung. One tumor of the left upper lung was resected by thoracoscopic surgery. Pathologically, the resected lesion consisted of benign spindle cells and was diagnosed as BML. The post-operative course was uneventful. Other lung nodules have been meticulously monitored at follow-up, and repeat CT two years later showed that these nodules had not increased at all in size and that no new lobe nodules had appeared. The present study indicates that pulmonary BML occurs in a low proportion of female with a history of uterine leiomyoma and treatment methods for it are diverse and controversial.

show abstract

Section: Discussionmentioning

confidence: 99%

Benign metastasizing leiomyoma of the lung: A case report and literature review

Wei

Chen

2015

Oncology Letters

View full text Add to dashboard Cite

show abstract

“…Although LPD is a different entity when compared with UMs, there might be a relation between morcellation of UMs and an iatrogenic development of this disease. Several studies which presented that LPD shrink under sex steroid hormone manipulation, including BSO [53][54][55], menopause [65], megestrol [66], SERM [55], AI [55,67], and GnRHa [55,56,68]. Laparoscopic myomectomy might result in the growth of multiple PM nodules mimicking LPD [31].…”

Section: Discussionmentioning

confidence: 99%

Oestrogen-Induced Angiogenesis and Implantation Contribute to the Development of Parasitic Myomas after Laparoscopic Morcellation

Lin

Huang

Chen³

et al. 2017

Journal of Minimally Invasive Gynecology

View full text Add to dashboard Cite

“…The histological differential diagnosis of pulmonary smooth muscle nodules includes BML, primary leiomyoma or leiomyosarcoma, metastatic leiomyosarcoma, pulmonary hamartoma, leiomyomatous hyperplasia and lymphangioleiomyomatosis [6,[13][14][15] , in which, however, the proliferating cells express HMB-45. Reported treatment methods include surgical resection of the nodules if possible, hysterectomy and bilateral oophorectomy, chemotherapy, progesterone and medical castration using luteinizing hormone-releasing analogue or the appropriate combination of them [2,8,16] . The clinical course of the pulmonary lesions varies from a chronic inactive appearance to a rapid progression leading to respiratory failure and death [16] .…”

Section: Discussionmentioning

confidence: 99%