Natural-enriched environments lead to enhanced environmental engagement and altered neurobiological resilience

Lambert, Kelly G.; Hyer, Molly M.; Bardi, Massimo; Rzucidlo, Amanda; Scott, Sally S.; Terhune-Cotter, Brennan; Hazelgrove, Ashley; Silva, Ilton; Kinsley, Craig Howard

doi:10.1016/j.neuroscience.2016.05.037

Cited by 55 publications

(54 citation statements)

References 42 publications

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“…The present study further demonstrated an increase in Fos-IR cells in the BM, where restraint stress- (Kubo et al 2004), avoidant task- (Duncan et al 1996;Silveria et al 2001), and anxiogenic drug-induced Fos expression have been reported (Singewald et al 2003). Anxiolytic effects of EE associated with reduced Fos expression in the amygdaloid nuclei have also been reported in a foot shockmotivated aversive task (Nikolaev et al 2002), water escape task (Lambert et al 2016), and predator smell avoidance task (Sotnikov et al 2014). The present findings further confirmed the effect of EE on Fos expression in the novel open field test.…”

Section: Effect Of Ee On Novel Open Field Behaviorsupporting

confidence: 80%

Effects of environmental enrichment on the activity of the amygdala in micrencephalic rats exposed to a novel open field

Matsuda

Ehara

Nakadate

et al. 2017

Congenital Anomalies

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Environmental enrichment (EE) mediatesrecovery from sensory, motor, and cognitive deficits and emotional abnormalities. In the present study, we examined the effects of EE on locomotor activity and neuronal activity in the amygdala in control and methylazoxymethanol acetate (MAM)-induced micrencephalic rats after challenge in a novel open field. Control rats housed in EE (CR) showed reduced locomotor activity compared to rats housed in a conventional cage (CC), whereas hyperactivity was seen in MAM rats housed in a conventional cage (MC) and in MAM rats housed in EE (MR).Novel open field exposure in both CC and MC resulted in a marked increase in Fos expression in the anterior and posterior parts of the basolateral amygdaloid nucleus, basomedial nucleus, and medial nucleus, whereas these increases in expression were not observed in CR. The effect of EE on Fos expression in the amygdala was different in MR exposed to a novel open field compared to CR. Furthermore, we observed a quite different pattern of Fos expression in the central nucleus of the amygdala between control and MAM rats. The present results suggest that neuronal activity in the amygdala that responds to anxiety is altered in MAM rats, especially when the rats are reared in EE. These alterations may cause behavioral differences between control and MAM rats.

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Section: Effect Of Ee On Novel Open Field Behaviorsupporting

confidence: 80%

Effects of environmental enrichment on the activity of the amygdala in micrencephalic rats exposed to a novel open field

Matsuda

Ehara

Nakadate

et al. 2017

Congenital Anomalies

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“…Although the animals in the Knickmeyer study were maternally reared, they were artificially weaned at a relatively young age and then housed in small social groups. It is plausible that differences in the environment shape social processing demands (Lambert et al, ; Lederbogen et al, ; Urakawa et al, ) and may have affected the trajectory of amygdala growth. This hypothesis is supported by a body of literature describing the impact of maternal deprivation on amygdala development and connectivity in human and nonhuman primates (de Campo et al, ; Gee et al, ; Olsavsky et al, ; Sabatini et al, ).…”

Section: Discussionmentioning

confidence: 99%

Amygdala growth from youth to adulthood in the macaque monkey

Schumann

Scott

Lee

et al. 2019

J of Comparative Neurology

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Emerging evidence suggests that the human amygdala undergoes extensive growth through adolescence, coinciding with the acquisition of complex socioemotional learning. Our objective was to longitudinally map volumetric growth of the nonhuman primate amygdala in a controlled, naturalistic social environment from birth to adulthood. Magnetic resonance images were collected at five time-points in 24 male and female rhesus macaques from 6 months to adulthood at 5 years. We then compared amygdala growth to other brain regions, including newly collected isocortical gray and white matter volumes, and previously published data on the same cohort.We found that amygdala volume increases by nearly 50% from age 6 months to 5 years. This dramatic growth is in contrast to overall brain and hippocampal volume, which peak near 3 years, white matter, which slows from 3 to 5 years, and isocortical gray, which has a net decrease. Similar to isocortical gray and hippocampal volumes, amygdala volume is~8% larger in males than females. Rate of growth does not differ by sex. Although the underlying neurobiological substrate for protracted amygdala growth into adulthood is unclear, we propose it may be due in part to the unique cellular development of immature neurons in paralaminar nucleus that mature in size and connectivity with age. Prolonged amygdala maturation raises the possibility that environmental and genetic perturbations that disrupt this trajectory may contribute to the emergence of psychiatric disorders, such as anxiety, depression, schizophrenia, and autism; all in which the amygdala is strongly implicated.

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“…Early EE studies demonstrated widespread effects on numerous CNS cell types and under varied physiological conditions in both small and large mammals [84,85,86,87,88]. Differential rearing in infant rhesus monkey shows that animals raised in larger groups demonstrate expansion of the CC and sustained improvement in cognitive performance versus age-matched, individually raised controls [89].…”

Section: Environmentally Influenced Changes In Myelin Structure and Fmentioning

confidence: 99%

All Wrapped Up: Environmental Effects on Myelination

Forbes

Gallo

2017

Trends in Neurosciences

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Summary To date, studies have demonstrated the dynamic influence of exogenous environmental stimuli on multiple regions of the brain. This environmental influence positively and negatively impacts programs governing myelination, and acts on myelinating oligodendrocyte (OL) cells across the entire human lifespan. Developmentally, environmental manipulation of OL progenitor cells (OPCs) has profound effects on the establishment of functional cognitive, sensory, and motor programs. Furthermore, central nervous system (CNS) myelin remains an adaptive entity in adulthood, sensitive to environmentally induced structural changes. Here, we discuss the role of environmental stimuli on mechanisms governing programs of CNS myelination under normal and pathological conditions. Importantly, we highlight how these extrinsic cues can influence the intrinsic power of myelin plasticity to promote functional recovery.

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Natural-enriched environments lead to enhanced environmental engagement and altered neurobiological resilience

Cited by 55 publications

References 42 publications

Effects of environmental enrichment on the activity of the amygdala in micrencephalic rats exposed to a novel open field

Effects of environmental enrichment on the activity of the amygdala in micrencephalic rats exposed to a novel open field

Amygdala growth from youth to adulthood in the macaque monkey

All Wrapped Up: Environmental Effects on Myelination

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