2013
DOI: 10.1017/s0007114513002675
|View full text |Cite
|
Sign up to set email alerts
|

Natural feed contaminant zearalenone decreases the expressions of important pro- and anti-inflammatory mediators and mitogen-activated protein kinase/NF-κB signalling molecules in pigs

Abstract: Zearalenone (ZEA) is an oestrogenic mycotoxin produced by Fusarium species, considered to be a risk factor from both public health and agricultural perspectives. In the present in vivo study, a feeding trial was conducted to evaluate the in vivo effect of a ZEA-contaminated diet on immune response in young pigs. The effect of ZEA on pro-inflammatory (TNF-a, IL-8, IL-6, IL-1b and interferon-g) and antiinflammatory (IL-10 and IL-4) cytokines and other molecules involved in inflammatory processes (matrix metallop… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

7
40
1
1

Year Published

2015
2015
2021
2021

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 70 publications
(49 citation statements)
references
References 75 publications
7
40
1
1
Order By: Relevance
“…ZEA competitively binds to estrogen receptors and causes alterations in the reproductive tract of laboratory mice, rats, guinea pigs, hamsters and rabbits and domestic animals and it is able to induce liver lesions with subsequent development of hepatocarcinoma and alterations of some enzymatic parameters of the hepatic function in rats, rabbits and gilts. ZEA has been shown to be immunotoxic and hepatotoxic and nephrotoxic and an enhancer of lipid peroxidation (Pistol et al, 2014).…”
Section: Zearalenonementioning
confidence: 99%
See 3 more Smart Citations
“…ZEA competitively binds to estrogen receptors and causes alterations in the reproductive tract of laboratory mice, rats, guinea pigs, hamsters and rabbits and domestic animals and it is able to induce liver lesions with subsequent development of hepatocarcinoma and alterations of some enzymatic parameters of the hepatic function in rats, rabbits and gilts. ZEA has been shown to be immunotoxic and hepatotoxic and nephrotoxic and an enhancer of lipid peroxidation (Pistol et al, 2014).…”
Section: Zearalenonementioning
confidence: 99%
“…The results of the diverse interactions of ZEA are manifested by functional and morphological alterations of the reproductive organs (Duca et al, 2012). ZEA is considered to be a risk factor from both public health and agricultural perspectives (Pistol et al, 2014). ZEA levels are regulated in international trade, depending on the end product into which the grain being tested will be incorporated (Summerell and Leslie, 2011).…”
Section: Zearalenonementioning
confidence: 99%
See 2 more Smart Citations
“…They are frequently found in foods predominantly cereals and forages [2,3]. Both the risk of substantial economic losses and the threat to human health could result from exposure to the toxins [4].…”
Section: Introductionmentioning
confidence: 99%