Natural flavylium-inspired far-red to NIR-II dyes and their applications as fluorescent probes for biomedical sensing

Sun, Yuanqiang; Sun, Peng; Li, Zhaohui; Qu, Lingbo; Guo, Wei

doi:10.1039/d2cs00179a

Cited by 53 publications

(23 citation statements)

References 209 publications

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“…16 Numerous kinds of fluorescent probes (e.g., fluorescent proteins, fluorescent dyes and fluorescent nanomaterial-based probes) have been employed to label and trace different molecules, proteins, cells, and tissues and their dynamic progress. [49][50][51][52][53][54][55][56][57][58] In particular, fluorescent proteins are suitable for labeling various cells, viruses, genes and so forth; fluorescent dyes are appropriate for imaging and analyzing antibodies, peptides, small molecule drugs and so on. With significant advances in nanotechnology, nanomaterials (e.g., II-VI quantum dots (QDs), carbon dots (CDs), upconverting nanoparticles (UCNPs) and silicon-based nanoparticles (SiNPs)) featuring attractive optical properties, have been exploited as novel high-performance fluorescent nanoprobes for biomedical imaging applications.…”

Section: Fluorescence Imagingmentioning

confidence: 99%

Fluorescence, ultrasonic and photoacoustic imaging for analysis and diagnosis of diseases

et al. 2023

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Section: Fluorescence Imagingmentioning

confidence: 99%

Fluorescence, ultrasonic and photoacoustic imaging for analysis and diagnosis of diseases

et al. 2023

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“…This explains why the NIR-II emitters with a PDT property are rare and precise molecular design should be conducted. Most NIR-II fluorophores have relatively low bandgaps of < 1.5eV, in which the efficiency of radiative decay is low and the nonradiative decay becomes dominant [ 89 , 90 , 91 ]. Thus, the nonradiative thermal deactivation-associated photothermal and PA effect are usually observed for NIR-II agents, which enables multifunctional properties.…”

Section: Photodynamic Nir-ii Aiegens For Subcutaneous Tumor Photother...mentioning

confidence: 99%

NIR-II AIEgens with Photodynamic Effect for Advanced Theranostics

et al. 2022

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Phototheranostics that concurrently integrates accurate diagnosis (e.g., fluorescence and photoacoustic (PA) imaging) and in situ therapy (e.g., photodynamic therapy (PDT) and photothermal therapy (PTT)) into one platform represents an attractive approach for accelerating personalized and precision medicine. The second near-infrared window (NIR-II, 1000–1700 nm) has attracted considerable attention from both the scientific community and clinical doctors for improved penetration depth and excellent spatial resolution. NIR-II agents with a PDT property as well as other functions are recently emerging as a powerful tool for boosting the phototheranostic outcome. In this minireview, we summarize the recent advances of photodynamic NIR-II aggregation-induced emission luminogens (AIEgens) for biomedical applications. The molecular design strategies for tuning the electronic bandgaps and photophysical energy transformation processes are discussed. We also highlight the biomedical applications, such as image-guided therapy of both subcutaneous and orthotopic tumors, and multifunctional theranostics in combination with other treatment methods, including chemotherapy and immunotherapy; and the precise treatment of both tumor and bacterial infection. This review aims to provide guidance for PDT agents with long-wavelength emissions to improve the imaging precision and treatment efficacy. We hope it will provide a comprehensive understanding about the chemical structure–photophysical property–biomedical application relationship of NIR-II luminogens.

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“…Compared with traditional imaging methods, including magnetic resonance imaging (MRI), computed tomography (CT) and ultrasound imaging (Poelma, 2016;Lim et al, 2019;Antequera et al, 2021), fluorescence imaging technology allows non-invasive detecting biomarkers with high sensitivity, quick response time and wonderful spatiotemporal resolution, which makes animal models of tracking pathology and clinical studies very attractive (Jun et al, 2020;Hanaoka et al, 2022;Qi et al, 2022;Sun et al, 2022). Fluorescencebased imaging typically uses small molecule fluorescent probes that are designed to bind/react with disease-based target biomarkers and offer measurable fluorescent signal changes for qualitative and quantitative analysis of analytes and imaging traces (Jia et al, 2022;Zhao L et al, 2022;Hou et al, 2022;Hou et al, 2020a;Gardner et al, 2021;Du et al, 2023;Li et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

H2S-based fluorescent imaging for pathophysiological processes

Jia

Zhang²,

Hou³

et al. 2023

Front. Chem.

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Hydrogen sulfide (H2S), as an important endogenous signaling molecule, plays a vital role in many physiological processes. The abnormal behaviors of hydrogen sulfide in organisms may lead to various pathophysiological processes. Monitoring the changes in hydrogen sulfide is helpful for pre-warning and treating these pathophysiological processes. Fluorescence imaging techniques can be used to observe changes in the concentration of analytes in organisms in real-time. Therefore, employing fluorescent probes imaging to investigate the behaviors of hydrogen sulfide in pathophysiological processes is vital. This paper reviews the design strategy and sensing mechanisms of hydrogen sulfide-based fluorescent probes, focusing on imaging applications in various pathophysiological processes, including neurodegenerative diseases, inflammation, apoptosis, oxidative stress, organ injury, and diabetes. This review not only demonstrates the specific value of hydrogen sulfide fluorescent probes in preclinical studies but also illuminates the potential application in clinical diagnostics.

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Natural flavylium-inspired far-red to NIR-II dyes and their applications as fluorescent probes for biomedical sensing

Abstract: This review summarizes the recent progress of natural flavylium-inspired far-red to NIR-II dyes and their applications as fluorescent probes for detecting and visualizing important biomedical species and events.

Cited by 53 publications

References 209 publications

Fluorescence, ultrasonic and photoacoustic imaging for analysis and diagnosis of diseases

Fluorescence, ultrasonic and photoacoustic imaging for analysis and diagnosis of diseases

NIR-II AIEgens with Photodynamic Effect for Advanced Theranostics

H2S-based fluorescent imaging for pathophysiological processes

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