Mass reduction is a primary design goal pursued in satellite structural design, since the launch cost is proportional to their total mass. The most common mass reduction method currently employed is to introduce honeycomb structures, with space qualified composite materials as facing materials, into the structural design, especially for satellites with larger masses. However, efficient implementation of these materials requires significant expertise in their design, analysis, and fabrication processes; moreover, the material procurement costs are high, therefore increasing the overall program costs. Thus, the current work proposes a low-cost alternative approach through the design and implementation of geometrically-shaped, parametrically-defined metal perforation patterns, fabricated by standard processes. These patterns included four geometric shapes (diamonds, hexagons, squares, and triangles) implemented onto several components of a structural design for a conceptual satellite, with a parametric design space defined by two scale factors and also two aspect ratio variations. The change in the structure’s fundamental natural frequency, as a result of implementing each pattern shape and parameter variation, was the selection criterion, due to its importance during the launcher selection process. The best pattern from among the four alternatives was then selected, after having validated the computational methodology through implementing experimental modal analysis on a scaled down physical model of a primary load-bearing component of the structural design. From the findings, a significant mass reduction percentage of 23.15%, utilizing the proposed perforation concept, was achieved in the final parametric design iteration relative to the baseline unperforated case while maintaining the same fundamental frequency. Dynamic loading analysis was also conducted, utilizing both the baseline unperforated and the finalized perforated designs, to check its capability to withstand realistic launch loads through applying quasi-static loads. The findings show that the final perforated design outperformed the baseline unperforated design with respect to the maximum displacements, maximum Von Mises stresses, and also the computed margin of safety. With these encouraging outcomes, the perforated design concept proved that it could provide an opportunity to develop low-cost satellite structural designs with reduced mass.