The natural history of aortoarteritis was studied in 88 patients (54 women and 34 men). The average age was 24.0±8.8 years at onset of symptoms and 28.3±9.9 years at diagnosis. The inflammatory disease involving the aorta, the arteries arising from the aorta, and, frequently, the pulmonary arteries. The inflammation leads to either stenosis and occlusion of the involved artery or aneurysm formation or both.1-5 The arterial lesions can lead to secondary hypertension, retinopathy, cardiac involvement, cerebrovascular events, and premature death. The course and prognosis of patients with aortoarteritis show wide variation, and few authors have published systematic studies documenting the natural history of this disease.6-9 While the etiology of aortoarteritis remains unknown, various modes of treatment including steroids, vascular surgery, and balloon angioplasty have been used for management of these patients.7"10-13 To make a decision about elective intervention, the physician must have data on the natural history and be able to make an objective assessment of the prognosis in the individual patient. Our study documents the clinical course, complications, and survival of 88 patients with aortoarteritis who had systematic follow-ups at our center.