Natural history and epidemiology of cleft lip and palate: a registry-based study in Iran (2000-19)

Abstract

The aim of this study was to provide the natural history and epidemiology of cleft lip and cleft palate in the northwest region of Iran between 2000 and 2019. Since 2000, infants born with birth defects have been registered in the Tabriz Registry of Congenital Anomalies (TRoCA). For this study, the information and data were collected using the TRoCA registry system. Prevalence of cleft lip and cleft palate was 1.48 (95% CI 1.34; 1.62) per 1000 live births over the past two decades in the region. The occurrence of cleft lip and cleft palate was more common in males than females. The fetal death ratio was 5 percent of live born children. The proportion of infants with cleft lip and cleft palate surviving to the second week was 54 percent. The results may have a role in planning and evaluating the strategies for primary prevention of cleft lip and cleft palate, particularly in high-risk populations.

Characteristics and Prevalence of Cleft Palate Patients in RSUP dr. Hasan Sadikin Bandung, Indonesia: 3 Years Retrospective Study

“…Research by Galeh et al (2020) in Iran showed result about 20.86% patient with cleft has family history with cleft lip or palate. 1 Other study was in Saudi arabia that reported there were 4 patient (25%) that has family history with cleft lip or palate. 5,14 This result explained that orofacial cleft is known to have an increased frequency in relatives of family members with a cleft.…”

“…Cleft lip with or without cleft palate are the most common congenital anomalies affecting the head and neck and the second most common congenital abnormalities in general. 1 Previous study explained that in New Haven, Connecticut cleft palate incidence is about 1 per 1593 live births. 2 Cleft palate occurs congenitally from failure of palatal shelf fusion.…”