Natural History and Influencing Factors of Chronic Urticaria in Children

Kim, Hyeona; Hyun, Myung Chul; 최봉석,

doi:10.4168/aair.2022.14.1.73

Cited by 7 publications

(3 citation statements)

References 42 publications

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“…2 In children, prevalence is estimated to be 0.1-0.3%. 3 Even though it has been classically known that children have a lower prevalence, 4 there are reports of a higher prevalence in pediatric patients (1.43%) compared with adults (0.86%). 2 Regarding the natural history of CU, there seems to be a wide variation in remission rates.…”

Section: Introductionmentioning

confidence: 99%

Pediatric chronic urticaria: Clinical and laboratory characteristics and factors linked to remission

Sandoval‐Ruballos

Domínguez

Landazuri

et al. 2023

Pediatric Allergy Immunology

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Background Chronic urticaria (CU) is defined as the occurrence of wheals/angioedema for ≥6 consecutive weeks. Until now, guidelines and publications addressing CU have focused mainly on adults. As a result, evidence and guidance in the pediatric population are scarce. Methods This study aims to describe clinical and laboratory findings in pediatric CU and to determine factors associated with remission. Results 185 patients, 54% female, median age at onset of 8.8 years. Angioedema was present in almost half. The most common type of CU was chronic spontaneous urticaria (CSU) in 74%. At least one atopic comorbidity was found in almost a third (35%). In addition, 8% had an autoimmune disorder (exclusively in CSU) and 9% had a psychiatric condition. Basopenia was found in 67% and was more frequently associated with CSU. The basophil activation test (BAT) was positive in 40%. With regard to remission, being of male sex, angioedema absence, the absence of physical triggers, and eosinophil counts >0.51 × 109/L were associated with shorter CU duration. Conclusion Atopy is a common condition in pediatric CU. CSU is the most common type. Autoimmune comorbidities and basopenia were significantly more common in CSU. In addition, ours is one of the few studies, assessing BAT utility in the pediatric population, being positive in a relevant percentage (40%). BAT positivity was more frequent in CSU. Our results suggest that the absence of angioedema and physical triggers, male sex, and eosinophil counts >0.51 × 109/L appear to be associated with a better prognosis in terms of remission.

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Section: Introductionmentioning

confidence: 99%

Pediatric chronic urticaria: Clinical and laboratory characteristics and factors linked to remission

Sandoval‐Ruballos

Domínguez

Landazuri

et al. 2023

Pediatric Allergy Immunology

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“…A previous study reported that 5.5% of pediatric patients with CSU had G. duodenalis, D. fragilis, and Blastocystissp. (Kim et al, 2022). Another study reported a 10% prevalence of IPI in CSU pediatric patients, and the most prevalent parasites were E. vermicularis, D. fragilis, G. duodenalis, and Blastocystis sp.…”

Section: Resultsmentioning

confidence: 99%

Incidence of Intestinal Parasites in Children With Chronic Spontaneous Urticaria

BUKHARI,

AKRAM

et al. 2023

Biol Clin Sci Res J

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This study aimed to investigate the incidence of intestinal parasites in children who have been diagnosed with chronic spontaneous urticaria. A prospective control study was conducted at the Pathology Department of MMDC, Multan. The study included a total of 150 children, both from government and private schools. The children were divided into two groups: group A comprised 80 children diagnosed with chronic spontaneous urticaria, and group B included 70 healthy children. Group A was assessed for intestinal infections, and those with parasites were given anti-parasitic therapy. The outcomes were then evaluated. Out of the participants in group A, 18 (22.5%) had intestinal parasitic infections (IPI), compared to 10 (14.2%) in group B. Although the incidence of IPI was higher in group A, the difference was not statistically significant (P=.181). Blastocystis sp. was found in 14 (17.5%) patients in group A and 10 (14.2%) in group B. The eosinophil percentage in group A was 2% (.6% - 3.7%), and in group B was 1.5% (.6% - 2.2%) (P= .045). The total IgE value in group A was 97.6 IU/mL (ranging from 29-246 IU/mL), and in group B was 31.6 IU/mL (ranging from 14.2-65.8 IU/mL) (P <.001). Patients diagnosed with IPI were treated with metronidazole; out of the 18 patients, 10 (55.5%) saw an end to their urticaria symptoms. The results of this study suggest that Blastocystis sp. and D. fragilis were the most common parasites found in children with urticaria, which can disrupt their lifestyle.

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“…Importantly, total levels of IgE were positively associated with disease duration. (r = 0.262, p = 0.021) ( 77 ). In CU adults, high IgE levels correlated with disease severity and duration, but not the clinical course of the disease ( 64 , 78 ).…”

Section: Cu and Atopic Diseasesmentioning

confidence: 99%

Comorbidities of Chronic Urticaria: A glimpse into a complex relationship

et al. 2022

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Chronic Urticaria (CU) is a chronic inflammatory, predominantly mast cell-driven disease, characterized by the development of wheals and/or angioedema for more than 6 weeks. It affects approximately 1%–5% of the total population worldwide and imposes a substantial burden on health-related quality of life, significantly affecting patients' daily life. The economic impact on the health system is also not negligible, with an estimated cost per patient per year of approximately 2.000 $ in the United States. Although the underlying pathophysiology is not fully explored, autoimmune mechanisms have been proposed, including type I (“autoallergy” by means of autoantibodies to self-antigens) and type IIb (autoimmunity). Atopic, autoimmune, and psychiatric disorders are prevalent comorbidities in both children and adults with Chronic Spontaneous Urticaria (CSU). Although malignancies, cardiovascular diseases and other comorbidities have also been reported as associated diseases in patients with CSU, data remain scarce. It is still unknown whether the aforementioned comorbidities share common pathophysiological mechanisms with specific endotypes of CSU. The current review aims to overview current data on comorbidities of CU, and furthermore to comment on the potential linked pathways underlying these diseases.

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Natural History and Influencing Factors of Chronic Urticaria in Children

Cited by 7 publications

References 42 publications

Pediatric chronic urticaria: Clinical and laboratory characteristics and factors linked to remission

Pediatric chronic urticaria: Clinical and laboratory characteristics and factors linked to remission

Incidence of Intestinal Parasites in Children With Chronic Spontaneous Urticaria

Comorbidities of Chronic Urticaria: A glimpse into a complex relationship

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