Natural history of advanced HIV disease in patients treated with zidovudane

Moore, Richard D.; Keruly, Jeanne C.; Richman, Douglas D.; Creagh-Kirk, Terri; Chaisson, Richard E.

doi:10.1097/00002030-199207000-00009

Cited by 36 publications

(23 citation statements)

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“…Most children in the younger age distribution were perinatally HIV-infected. As seen in Table 3, among the 95 long-term survivors who had developed AIDS-defining conditions, 14 (15%) had absolute CD4 counts Ն500 cells/mm 3 26 (27%) had values between 200 and 500 cells/mm 3 , and 55 (58%) had Ͻ200 cells/mm 3 (26% of group 1, 48% of group 2, and 62% of group 3 children). Among children with CD4 counts Ն500 cells/mm 3 , lymphoid interstitial pneumonitis was the most common AIDS-defining condition followed by recurrent bacterial infections.…”

Section: Resultsmentioning

confidence: 98%

“…This group was comprised of 31 perinatally infected children and 9 children infected by neonatal transfusion. Their mean age was 10.0 years (range 8 to 14 years), mean absolute CD4 count was 823 cells/mm 3 (range 504 to 3030 cells/mm 3 ); 26 children (65%) were black, 8 (20%) were white, and 6 (15%) were Hispanic. Eighty-two percent of these children had received antiretroviral therapy, and as with the other children in the study, lymphadenopathy was present in a large number of patients (85%).…”

Section: Resultsmentioning

confidence: 99%

“…Many of the patients who had not had an AIDS-defining condition had had symptoms (ie, at least 70% of all patients had experienced lymphadenopathy) although clinical findings varied with CD4 strata as expected. A considerable proportion of patients (42% in the perinatal group and 54% in the transfusion group) had absolute CD4 counts less than 200 cells/mm 3 .…”

Section: Discussionmentioning

confidence: 98%

“…Among this cohort of pediatric long-term survivors, 20% of infected children (n ϭ 40) had an absolute CD4 count Ͼ500 cells/mm 3 and no AIDS-defining conditions. The demographics of this population Prevalence of most frequent clinical findings among pediatric long-term survivors stratified by absolute CD4 count and presence or absence of previous AIDS-defining conditions.…”

Section: Discussionmentioning

confidence: 99%

“…The availability of antiretroviral therapy and early medical intervention with prophylaxis and treatment of infections has altered to some degree the natural history of HIV infection and increased survival time of infected patients. 3 Long-term survivors provide a unique opportunity to investigate the immunologic, virologic, and genetic characteristics of HIV-infected children to determine what factors may slow progression to disease and death.…”

mentioning

confidence: 99%

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A Descriptive Survey of Pediatric Human Immunodeficiency Virus–infected Long-term Survivors

Nielsen

McSherry

Petru³

et al. 1997

Pediatrics

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ABSTRACT. Objective. To identify the population of human immunodeficiency virus-infected pediatric longterm survivors (LTS) followed in major medical institutions in California, Florida and New Jersey.Methods. A cross-sectional survey was performed with data collection forms sent to all investigators. Demographic, clinical, and laboratory data were obtained on all living patients 8 years infected in the perinatal period with human immunodeficiency virus.Results. A total of 143 perinatally infected and 54 children infected by neonatal transfusion were identified. Fifty-four children (27%) had absolute CD4 counts 500 cells/mm 3 (group 1: mean age 9.8 years), 54 children (27%) had CD4 counts between 200 and 500 cells/mm 3 (group 2: mean age 10.1 years), and 89 children (45%) had CD4 counts <200 cells/mm 3 (group 3: mean age 10.4 years). Ninety-five (48%) patients had developed AIDS defining conditions; 14 (26%) in group 1, 26 (48%) in group 2, and 55 (62%) in group 3. Ninety-two percent of patients had received antiretrovirals. Perinatally human immunodeficiency virus-infected children tended to be younger (mean age 9.8 years) than children infected via a blood transfusion (mean age 11 years). Generalized lymphadenopathy was the most prevalent clinical finding. Lymphoid interstitial pneumonia and recurrent bacterial infections were the most prevalent acquired immune deficiency syndrome-defining conditions. Twenty percent of LTS had CD4 counts 500 cells/mm 3 and no immune deficiency syndrome-defining conditions.Conclusions. Pediatric LTS were in variable stages of disease progression. The proportion of children within each CD4 strata did not differ by mode of acquisition of infection. Increased CD4 counts were inversely proportional to age. Only 20% of pediatric LTS had minimal to no disease progression. Pediatrics 1997;99(4). URL: http: //www.pediatrics.org/cgi/content/full/99/4/e4; HIV, pediatric long-term survivors, slow disease progression.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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