Natural history of aortoarteritis: An angiographic study in 26 survivors

Mandalam, K. Ravi; Subramanyan, Raghavan; Joseph, S.; Rao, V. R. K.; Gupta, Arun Kumar; Unni, N. Madhavan; Rao, A. Srinivasa; Kumar, Sunil; Balakrishnan, K.G.; Neelakandhan, Kurur Sankaran

doi:10.1016/s0009-9260(05)82912-5

Cited by 13 publications

(5 citation statements)

References 12 publications

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“…A recent study reported 10-year event-free survival, relapse-free survival and complication-free survival rates approaching 48, 70 and 54% respectively [31]. Likewise, other series have reported no progression in 70 and 77%, respectively [30,34], while higher levels of relapse have been previously reported elsewhere (reviewed in [35]). Although these differences are likely multifactorial and related in part to a variable definition of vascular progression, they may also reflect greater historic dependence upon CS monotherapy.…”

Section: Natural History Of Takmentioning

confidence: 85%

Takayasu arteritis: advanced understanding is leading to new horizons

2018

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Although outcomes in Takayasu arteritis (TAK) are improving, diagnosis is typically delayed and significant arterial injury accrues. While wider use of non-invasive imaging is impacting this, the onus remains with clinicians to consider a diagnosis of TAK earlier. Meanwhile, morbidity and mortality in TAK remains increased. Herein we review the current situation, outline recent advances and summarize remaining challenges. Understanding of disease pathogenesis remains poor. However, recent genetic data and identification of pathogenic cytokines may facilitate the search for biomarkers capable of distinguishing active and inactive disease, inflammatory and non-inflammatory arterial remodelling. Imaging is critical for TAK, and each modality has important strengths and limitations. Dependence upon CS therapy remains too high. However, the impact of combination immunosuppressive therapy is now recognized, biologic therapies are increasingly available and new agents offer promise. Multicentre clinical trials are now required, and these will depend upon development of defined clinical and imaging end-points.

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Section: Natural History Of Takmentioning

confidence: 85%

Takayasu arteritis: advanced understanding is leading to new horizons

2018

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“…It is the commonest cause of renovascular hypertension in Asian children 315 . Its long term prognosis is studies in few series and the mortality ranges from 3 to 15% 322, 323, 324…”

Section: Hf Situations Specific To Indiamentioning

confidence: 99%

CSI position statement on management of heart failure in India

Guha

Harikrishnan

Ray

et al. 2018

Indian Heart Journal

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“…We observed idiopathic cystic medical necrosis in the aortic specimen, which did not contradict the diagnosis of Takayasu's arteritis. It has been estimated that aneurysms occur in 18% of patients with Takayasu's arteritis (9). SVA ruptures may occur spontaneously (triggered by chest trauma or exertion), or they may be iatrogenic.…”

Section: Discussionmentioning

confidence: 99%

Ruptured Right Sinus of Valsalva Aneurysm Caused by Suspected Takayasu's Arteritis

et al. 2016

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A sinus of Valsalva aneurysm (SVA) is a rare aortic anomaly. The most common complication is a rupture into the right ventricle and atrium. An SVA rupture into the left ventricle is a rare event. A 42-year-old man visited an outpatient clinic due to worsening exertional dyspnea. A loud to-and-fro heart murmur was detected, and echocardiography revealed a right SVA that had ruptured into the left ventricle, inducing acute heart failure. Computed tomography imaging allowed us to determine that the right SVA had been caused by asymptomatic Takayasu's arteritis. The patient was treated with prednisolone and the right SVA rupture was surgically repaired.

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Natural history of aortoarteritis: An angiographic study in 26 survivors

Cited by 13 publications

References 12 publications

Takayasu arteritis: advanced understanding is leading to new horizons

Takayasu arteritis: advanced understanding is leading to new horizons

CSI position statement on management of heart failure in India

Ruptured Right Sinus of Valsalva Aneurysm Caused by Suspected Takayasu's Arteritis

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