Natural History of Cutaneous Human Papillomavirus (HPV) Infection in Men: The HIM Study

Hampras, Shalaka S.; Giuliano, Anna R.; Lin, Hui‐Yi; Fisher, Kate; Abrahamsen, Martha; Sirak, Bradley; Iannacone, Michelle R.; Gheit, Tarik; Tommasino, Massimo; Rollison, Dana E.

doi:10.1371/journal.pone.0104843

Cited by 55 publications

(47 citation statements)

References 38 publications

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“…The overall point prevalence of β-HPV infections in the cervix in the present investigation (15%) was considerably lower than those we observed using the same assay methodology in a study of healthy men for the anal canal (54.3%), genitals (77.7%), external genital lesions (61.1%), as well as the oral cavity (29.3%) (5,18,19). Moreover, infection by two or more β-HPVs was not detected in the same cervical specimen despite the fact that multiple β-HPVs are commonly observed in the skin of healthy individuals and organ transplant recipients (20,21), as well as in male genitals where we detected up to 19 viral types simultaneously (3,19,22). …”

Section: Discussionmentioning

confidence: 66%

Cervical Infection with Cutaneous Beta and Mucosal Alpha Papillomaviruses

Sichero

El‐Zein

Nunes

et al. 2017

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Alpha-human papillomavirus (α-HPV) play a causal role in cervical cancer but little is known about the epidemiology of genital Beta-HPV infection. Methods We used Luminex and polymerase chain reaction (PCR) hybridization to detect β- and α-HPVs prevalence at enrolment and 12-months follow-up in cervical samples from 505 women enrolled in the Ludwig-McGill cohort study. We compared epidemiological correlates of both β- and α-HPVs and compared genotypes between these genera with respect to co-occurrence and association with cervical cytological abnormalities. Results Infection with β-HPV types was more prevalent than that with α-HPV types at both visits (cumulative prevalences: 27.3% vs. 21.6%, respectively, P=0.034). β-HPVs were mostly transient, however, only 1.98% women retained their original positivity at 12 months, whereas, persistence was higher for α-HPVs (5.15%) (P = 0.007). Age, parity, and sexual activity variables were predictors of α-HPV but not of β-HPV. α- and β-HPV types occurred independently. Increased risk of cervical abnormalities was restricted to women infected with α-9 or α-6 HPV types. We found no epidemiological correlates for β-HPV infections. Conclusions Detection of β-HPV types in the cervix tends to occur as random and transient episodes not explained via the sexual-transmission correlates that characterize infections by α-HPVs. Impact Although it is plausible that β-HPVs may play a direct or indirect carcinogenic role the lack of epidemiological correlates for detection episodes of these viruses and lack of association with cervical lesions speak against their ancillary role as sexually transmitted agents in cervical carcinogenesis.

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Section: Discussionmentioning

confidence: 66%

Cervical Infection with Cutaneous Beta and Mucosal Alpha Papillomaviruses

Sichero

El‐Zein

Nunes

et al. 2017

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…With more sensitive testing available, studies show that HPV infection is more commonly the rule, not the exception. HPV types associated with the alpha species predominate in the anogenital area but other HPV types such as the beta and gamma HPV types, once thought to be predominantly cutaneous only, can also be commonly detected 8-10 . Since the lifetime risk of developing invasive cervical cancer is much lower at 0.6% 11 , cervical cancer should be regarded as a rare complication of a very common infection by the human papillomavirus.…”

Section: Hpv and Cervical Carcinogenesismentioning

confidence: 99%

Does the vaginal microbiota play a role in the development of cervical cancer?

Kyrgiou

Mitra

Moscicki

2017

Translational Research

200

174

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Persistent infection with oncogenic Human Papillomavirus (HPV) is necessary but not sufficient for the development of cervical cancer. The factors promoting persistence as well those triggering carcinogenetic pathways are incompletely understood. Rapidly evolving evidence indicates that the vaginal microbiome (VM) may play a functional role (both protective and harmful) in the acquisition and persistence of HPV, and subsequent development of cervical cancer. The first studies examining the vaginal microbiome and the presence of an HPV infection using next generation sequencing techniques (NGS) identified higher microbial diversity in HPV-positive as opposed to HPV-negative women. Furthermore, there appears to be a temporal relationship between the VM and HPV infection in that specific community state types (CSTs) may be correlated with a higher chance of progression or regression of the infection. Studies describing the VM in women with pre-invasive disease (squamous intra-epithelial neoplasia – SIL) consistently demonstrate a dysbiosis in women with the more severe disease. Although it is plausible that the composition of the VM may influence the host innate immune response, susceptibility to infection and the development of cervical disease, the studies to date do not prove causality. Future studies should explore the causal link between the VM and the clinical outcome in longitudinal samples from existing biobanks.

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“…Among healthy individuals, advanced age [74, 75] and a positive history of blistering sunburn [75] and of cSCC were associated with β-HPV DNA detection and persistence [52, 74]. It was further reported that the risk for cSCC increased with the number of β-HPVs detected in EBH among ICs [56].…”

Section: Epidemiology Of Beta Hpv Associated Diseasesmentioning

confidence: 99%

Beta Human Papillomavirus and Associated Diseases

et al. 2019

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The cutaneous human papillomavirus (HPV), mostly from β- and γ-HPV genus, is ubiquitously distributed throughout the human body and may be part of the commensal flora. The association of β-HPVs and cutaneous squamous cell carcinoma (cSCC) development was initially reported in patients with the rare genetic disorder Epidermodysplasia verruciformis. Likewise, immunosuppressed organ transplant recipients have an increased susceptibility to β-HPV infections in the skin as well as to cSCC development. Although ultraviolet radiation (UVR) is the main risk factor of cSCC, experimental data points toward β-HPVs as co-carcinogens, which appear to be required solely at early stages of skin carcinogenesis by facilitating the accumulation of UVR-induced DNA mutations. Several epidemiological studies relying on different biomarkers of β-HPV infections have also been conducted in immunocompetent individuals to access their association with cSCC development. Additionally, in vivo and in vitro studies are presenting cumulative evidence that E6 and E7 proteins from specific β-HPVs exhibit transforming activities and may collaborate with different environmental factors in promoting carcinogenesis. Nevertheless, further research is crucial to better understand the pathological implications of the broad distribution of these HPVs.

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Natural History of Cutaneous Human Papillomavirus (HPV) Infection in Men: The HIM Study

Cited by 55 publications

References 38 publications

Cervical Infection with Cutaneous Beta and Mucosal Alpha Papillomaviruses

Cervical Infection with Cutaneous Beta and Mucosal Alpha Papillomaviruses

Does the vaginal microbiota play a role in the development of cervical cancer?

Beta Human Papillomavirus and Associated Diseases

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