Natural history of disseminated intravascular coagulation diagnosed based on the newly established diagnostic criteria for critically ill patients: Results of a multicenter, prospective survey*

Gando, Satoshi; Saitoh, Daizoh; Ogura, Hiroshi; Mayumi, Toshihiko; Koseki, Kazuhide; Ikeda, Toshiaki; Ishikura, Hiroyasu; Iba, Toshiaki; Ueyama, Masashi; Eguchi, Yawara; Ohtomo, Yasuhiro; Okamoto, Kohji; Kushimoto, Shigeki; Endo, Shunsuke; Shimazaki, Shuji

doi:10.1097/01.ccm.0000295317.97245.2d

Cited by 221 publications

(185 citation statements)

References 18 publications

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“…Based on the results of a subgroup analysis of our previous prospective study, we anticipated that the mortality rate of the present study would be 22 to 44% in the antithrombin arm and the control arm, respectively [24,30]. Indeed, the probability of death based on the APACHE II score of the two groups (Table 3) was approximately 30 to 40% [21].…”

Section: Discussionmentioning

confidence: 99%

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A Randomized, Controlled, Multicenter Trial of the Effects of Antithrombin on Disseminated Intravascular Coagulation in Patients With Sepsis

Gando

Saitoh²,

Ishikura³

et al. 2013

Chest

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Section: Discussionmentioning

confidence: 99%

“…Organ dysfunction was assessed according to the sequential organ failure assessment (SOFA) score [22]. A DIC diagnosis was made based on the JAAM DIC diagnostic criteria [23,24]. Overt DIC scores calculated based on the International Society on Thrombosis and Haemostasis (ISTH) scoring system were also used [25].…”

Section: Study Medicationsmentioning

confidence: 99%

A Randomized, Controlled, Multicenter Trial of the Effects of Antithrombin on Disseminated Intravascular Coagulation in Patients With Sepsis

Gando

Saitoh²,

Ishikura³

et al. 2013

Chest

Self Cite

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“…The acute‐phase criteria was formulated for the purpose of facilitating early‐stage DIC diagnoses, of the 3 diagnostic criteria, DIC should be diagnosed for the most widespread coagulopathies 382, 394. This criterion has become the most widely‐used diagnostic criterion for sepsis‐associated DIC in Japan because of the simplicity of its associated diagnostic procedures.…”

Section: Cq16: Diagnosis and Treatment Of Disseminated Intravascular mentioning

confidence: 99%

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG2016)

Nishida

Ogura

Egi

et al. 2018

Acute Medicine & Surgery

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157

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Background and PurposeThe Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG 2016), a Japanese‐specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in February 2017 in Japanese. An English‐language version of these guidelines was created based on the contents of the original Japanese‐language version.MethodsMembers of the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine were selected and organized into 19 committee members and 52 working group members. The guidelines were prepared in accordance with the Medical Information Network Distribution Service (Minds) creation procedures. The Academic Guidelines Promotion Team was organized to oversee and provide academic support to the respective activities allocated to each Guideline Creation Team. To improve quality assurance and workflow transparency, a mutual peer review system was established, and discussions within each team were open to the public. Public comments were collected once after the initial formulation of a clinical question (CQ), and twice during the review of the final draft. Recommendations were determined to have been adopted after obtaining support from a two‐thirds (>66.6%) majority vote of each of the 19 committee members.ResultsA total of 87 CQs were selected among 19 clinical areas, including pediatric topics and several other important areas not covered in the first edition of the Japanese guidelines (J‐SSCG 2012). The approval rate obtained through committee voting, in addition to ratings of the strengths of the recommendation and its supporting evidence were also added to each recommendation statement. We conducted meta‐analyses for 29 CQs. Thirty seven CQs contained recommendations in the form of an expert consensus due to insufficient evidence. No recommendations were provided for 5 CQs.ConclusionsBased on the evidence gathered, we were able to formulate Japanese‐specific clinical practice guidelines that are tailored to the Japanese context in a highly transparent manner. These guidelines can easily be used not only by specialists, but also by non‐specialists, general clinicians, nurses, pharmacists, clinical engineers, and other healthcare professionals.

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“…In this study, we applied the Japanese Association for Acute Medicine (JAAM) criteria to diagnose DIC [12], and sepsis was defined as the presence of infection together with systemic inflammatory response syndrome [13].…”

Section: Patients and Study Designmentioning

confidence: 99%

A retrospective comparative study of recombinant human thrombomodulin and gabexate mesilate in sepsis-induced disseminated intravascular coagulation patients

Takazono

Nakamura

Imamura

et al. 2014

Journal of Infection and Chemotherapy

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The novel biological agent recombinant human thrombomodulin (rhTM) has been used clinically in Japan to treat disseminated intravascular coagulation (DIC) since 2008.Previous studies have shown the efficacy of rhTM versus heparin therapy or non-rhTM therapy. We retrospectively evaluated and compared the efficacies of rhTM and gabexate mesilate (GM) in patients diagnosed with sepsis-induced DIC. From September 2010 to October 2012, patients with sepsis-induced DIC who were treated with rhTM (n = 13) or GM (n = 10) at Nagasaki Municipal Hospital were extracted.Patients receiving other anticoagulants in combination were excluded. Clinical information, laboratory data, Sequential Organ Failure Assessment (SOFA) scores, and DIC scores were obtained from the medical records. Mortality at days 7 and 30 after DIC diagnosis and changes in laboratory data and SOFA scores from days 1-7 were evaluated. The groups' clinical characteristics did not differ, except for the relatively higher C-reactive protein (CRP) levels in the rhTM group (P = 0.0508). The survival rates of the rhTM and GM groups on days 7 and 30 were 92.3%, 69.2% and 80%, 70%, respectively, both group indicated similar mortality. However, on day 7, the platelet counts, SOFA scores, and CRP levels significantly improved in the rhTM group; the platelet counts and SOFA scores did not improve significantly in the GM group. The 4 platelet counts of the rhTM group significantly improved compared to the GM group (P=0.004). Recombinant human thrombomodulin might be more effective for sepsis-induced DIC than GM.

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Natural history of disseminated intravascular coagulation diagnosed based on the newly established diagnostic criteria for critically ill patients: Results of a multicenter, prospective survey*

Abstract: This prospective survey demonstrated the natural history of DIC patients diagnosed by the JAAM DIC diagnostic criteria in a critical care setting. The study provides further evidence of a progression from the JAAM DIC to the ISTH overt DIC.

Cited by 221 publications

References 18 publications

A Randomized, Controlled, Multicenter Trial of the Effects of Antithrombin on Disseminated Intravascular Coagulation in Patients With Sepsis

A Randomized, Controlled, Multicenter Trial of the Effects of Antithrombin on Disseminated Intravascular Coagulation in Patients With Sepsis

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG2016)

A retrospective comparative study of recombinant human thrombomodulin and gabexate mesilate in sepsis-induced disseminated intravascular coagulation patients

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