Natural history of fundic gland polyposis in patients with familial adenomatosis coli/Gardner's syndrome

Iida, Mitsuo; Yao, Tsuneyoshi; Itoh, Hideaki; Watanabe, Hidenobu; Kohrogi, Norio; Shigematsu, Akihiro; Iwashita, Akinori; Fujishima, Masatoshi

doi:10.1016/0016-5085(85)90203-3

Cited by 64 publications

(25 citation statements)

References 17 publications

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“…Gastric fundic gland polyposis may appear as early as in the first decade of life, and while it can increase in number and size gradually, it does not significantly increase the risk of gastric cancer, 34,39 although one such case report exists. 35 On the other hand, gastric adenomas may be precursors of malignancy.…”

Section: Frequency Of Duodenal Cancermentioning

confidence: 94%

Gastroduodenal lesions in familial adenomatous polyposis

Kashiwagi

Spigelman

2000

Surg Today

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Prophylactic colectomy is generally recommended for patients with familial adenomatous polyposis (FAP) who are inevitably affected with large bowel cancer. After prophylactic colectomy has been performed, gastrointestinal malignancy is the leading cause of death. Duodenal adenomas are found in patients with FAP and the adenoma-carcinoma sequence exists in the FAP duodenum, suggesting that treatment of duodenal polyps might be beneficial. Several methods of treatment for duodenal lesions in patients with FAP have been reported, but the current treatment options are not ideal. The nonsteroid anti-inflammatory drugs, sulindac and aspirin, are used for chemoprevention, while recently developed cyclooxygenase-2 inhibitors may be of some use in the future. Endoscopic polypectomy has been attempted for duodenal polyps and open surgical polypectomy has proven to be effective for selected patients. Photodynamic therapy and Argon plasma coagulation may be suitable to treat carpeted polyposis. New methods of duodenal resection, such as pancreas-preserving duodenectomy and pylorus-preserving pancreaticoduodenectomy, might be considered for severe duodenal polyposis; however, because prophylactic duodenal surgery has been considered too aggressive, surveillance duodenoscopy is usually performed to detect duodenal cancer at an early stage.

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Section: Frequency Of Duodenal Cancermentioning

confidence: 94%

Gastroduodenal lesions in familial adenomatous polyposis

Kashiwagi

Spigelman

2000

Surg Today

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“…FGPs have generally been regarded as nonneoplastic lesions, either hamartomatous or hyperplastic/functional in nature. 16,19,20 Although some studies have reported no differences in the histology between sporadic FGPs and FGPs in patients with FAP, 18 -20 others have disputed this. In contrast to sporadic FGPs, FGPs in patients with FAP frequently show foveolar dysplasia, 8,[21][22][23] including a 25% prevalence of low-grade dysplasia in FAP-associated FGPs.…”

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confidence: 92%

Fundic Gland Polyps in Familial Adenomatous Polyposis

Abraham

Nobukawa

Giardiello

et al. 2000

The American Journal of Pathology

202

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“…5 Syndromic FGPs arise in patients with FAP, have been reported in 12.5% to 84% of patients with FAP, occur in a younger age group, and equally affect men and women. 4,[6][7][8][9][10][11][12][13] Epithelial dysplasia is more common Upon completion of this activity you will be able to:• describe the features of sporadic fundic gland polyps with low-grade dysplasia in terms of the incidence of these polyps, patient characteristics, and pathologic and immunohistochemical findings.• compare and differentiate between fundic gland polyps with low-grade dysplasia in the sporadic and syndromic setting.The ASCP is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The ASCP designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit ™ per article.…”

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confidence: 99%

Sporadic Fundic Gland Polyps With Low-Grade Dysplasia: A Large Case Series Evaluating Pathologic and Immunohistochemical Findings and Clinical Behavior

Levy

Bhattacharya

2015

American Journal of Clinical Pathology

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Objectives: Fundic gland polyps (FGPs) occur in two clinicalFundic gland polyps (FGPs) are the most common type of gastric polyp. 1,2 They typically occur in the body and fundus of the stomach and are composed of cystically dilated oxyntic glands lined by attenuated chief, parietal, and mucous neck cells. The polyp surface is lined by gastric foveolar epithelium. FGPs occur in two different clinical settings, sporadic and syndromic (familial adenomatous polyposis, or FAP).Sporadic FGPs have been reported in 0.8% to 1.9% of patients who undergo upper endoscopy. 3,4 They are slightly more common in women than in men, and their occurrence has been associated with prolonged use of proton pump inhibitors (PPIs). 3,4 In sporadic FGPs, low-grade epithelial dysplasia has been described, but its prevalence is extremely rare (approximately 1%). 5 Syndromic FGPs arise in patients with FAP, have been reported in 12.5% to 84% of patients with FAP, occur in a younger age group, and equally affect men and women. 4,[6][7][8][9][10][11][12][13] Epithelial dysplasia is more common Upon completion of this activity you will be able to:• describe the features of sporadic fundic gland polyps with low-grade dysplasia in terms of the incidence of these polyps, patient characteristics, and pathologic and immunohistochemical findings.• compare and differentiate between fundic gland polyps with low-grade dysplasia in the sporadic and syndromic setting.The ASCP is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The ASCP designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit ™ per article. Physicians should claim only the credit commensurate with the extent of their participation in the activity. This activity qualifies as an American Board of Pathology Maintenance of Certification Part II Self-Assessment Module.The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.Exam is located at www.ascp.org/ajcpcme.

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Natural history of fundic gland polyposis in patients with familial adenomatosis coli/Gardner's syndrome

Cited by 64 publications

References 17 publications

Gastroduodenal lesions in familial adenomatous polyposis

Gastroduodenal lesions in familial adenomatous polyposis

Fundic Gland Polyps in Familial Adenomatous Polyposis

Sporadic Fundic Gland Polyps With Low-Grade Dysplasia: A Large Case Series Evaluating Pathologic and Immunohistochemical Findings and Clinical Behavior

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