Natural history of genital warts.

Oriel, J D

doi:10.1136/sti.47.1.1

Cited by 257 publications

(213 citation statements)

References 21 publications

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“…It is possible that these women who were attending OPD with symptomatic complaints, may not really be normal women in strict sense, thus they may be having latent or an occult or commensal papillomavirus infection, that is, the presence of HPV DNA in the absence of a visible, histologic or cytologic abnormality. Oriel (1971) coined the lag period between exposure to HPV infection and development of clinical disease as 'latent infection', which was approximately 4 months, which is corroborated by Kreider et al (1987) experimentally, in their studies. The reason may be that the virus might be present in latent state and/or in unintegrated form without affecting cellular morphology, which shows up in Pap test.…”

Section: Discussionmentioning

confidence: 77%

Telomerase activity as an adjunct to high-risk human papillomavirus types 16 and 18 and cytology screening in cervical cancer

et al. 2006

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Telomerase is a ribonucleoprotein comprising an RNA template, the telomerase-associated protein and its catalytic subunit, human telomerase reverse transcriptase (hTERT). Telomerase activation is a critical step in cellular immortalisation and development of cancer. Enhanced telomerase activity has been demonstrated in cervical cancer. In the present study telomerase activity and hTERT mRNA expression were evaluated and correlated with the presence of human papillomavirus (HPV) infection and cytological changes in the cervical lesions. Telomerase activity was assayed by telomeric repeat amplification protocol, hTERT mRNA expression by reverse transcriptase polymerase chain reaction and presence of high risk HPV (HR-HPV) infection by polymerase chain reaction. Out of 154 cervical samples of different cytology, 90 (58.44%) were positive for HR-HPV types 16/18, while among 55 normal cervical scrapes, 10 (18.18%) were HPV DNA positive. All 59 invasive cancer samples showed a very high telomerase activity. Among dysplasia, seven (63.6%) mild dysplasia, 18 (100%) of moderate, 20 (100%) of severe dysplasia and 6 (100%) carcinoma in situ (CIS) samples were positive with mild to moderate to high to very high telomerase activity respectively. Seven (12.7%) samples of apparently normal cervical scrapes were weakly positive for telomerase activity. We observed a good correlation (Po0.001) between telomerase activity and HR-HPV 16/18 positivity with a sensitivity of 88.1% for HPV and 100% for telomerase activity. It is suggested that telomerase activity may be used as an adjunct to cytology and HPV DNA testing in triaging women with cervical lesions.

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Section: Discussionmentioning

confidence: 77%

Telomerase activity as an adjunct to high-risk human papillomavirus types 16 and 18 and cytology screening in cervical cancer

et al. 2006

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“…In previous studies, urethral condyloma was found in about 20% of all genital condylomas [7][8][9][10][11]. Our study showed that urethral condyloma accounted for 7.3% of all genital condylomas.…”

Section: Discussionmentioning

confidence: 61%

“…However the most commonly occurring disease related to HPV in men is condyloma acuminate (genital condyloma), which is a nonmalignant disease [6]. Most of the previous studies regarding genital condyloma have been about penile, scrotal, anal and urethral condyloma, showing that urethral and meatal condyloma accounted for 20% of genital condyloma [7][8][9][10][11]. Unlike other genital warts, urethral warts require invasive procedures, such as urethro-cystoscopy for diagnosis and treatment [12].…”

Section: Introductionmentioning

confidence: 99%

Type Distribution of Human Papillomavirus in Genital Warts of Korean Men

Ryu¹,

Cho²,

Lee³

et al. 2017

Urogenit Tract Infect

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Purpose:To analyze the distribution of human papillomavirus (HPV) types and the characteristics of genital condyloma in Korean men. Materials and Methods: Between January 2015 and December 2015, we reviewed the medical charts of 435 male patients diagnosed with genital condyloma. A total of 441 samples were identified. The detection rate of each HPV type and its associated characteristics (age, number of HPV types, low-risk and/or high-risk types, number of lesions) were analyzed. Our sample population was divided into two groups: The non-urethral condyloma group and the urethral condyloma group. In addition, subgroup analysis was also performed. Results: Among the total 441 specimens, 409 (92.7%) were non-urethral condyloma and 32 (7.3%) were urethral condyloma. Single-type infection was observed in 56.7% and multiple-type infection was seen in 43.3%. HPV type 6 and type 11 were the most common types in total genital condyloma and subgroups. HPV type 11, which was detected in 43.8% of those in the urethral condyloma group and in 22.0% of those in the non-urethral condyloma group (p=0.009), showed a statistically significant difference with respect to the type-specific detection rate. Conclusions: As in previous studies, our study also showed that HPV type 6 was the most prevalent type among all genital condylomas, followed by HPV type 11. A subgroup analysis also showed the same result.

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“…Oriel (1971) 14 e Schofield (1979) 15 também revelam que as verrugas genitais são mais comuns em homens que em mulheres.…”

Section: Discussionunclassified

“…Nosso trabalho encontrou um maior número de casos em pacientes adolescentes (15)(16)(17)(18)(19), em comparação com a pré-adolescência (10)(11)(12)(13)(14), o que se explica por uma coitarca mais tardia. Rama 16 não comparou as fases de adolescência e pré-adolescência, mas encontrou uma maior prevalência em mulheres com menos de 25 anos de idade.…”

Section: Discussionunclassified

Prevalência de Condiloma Acuminado no Município de Campo Grande – Mato Grosso do Sul, no Período de 2006 a 2009

Simão¹

2010

J bras Doenças Sex Transm

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Natural history of genital warts.

Cited by 257 publications

References 21 publications

Telomerase activity as an adjunct to high-risk human papillomavirus types 16 and 18 and cytology screening in cervical cancer

Telomerase activity as an adjunct to high-risk human papillomavirus types 16 and 18 and cytology screening in cervical cancer

Type Distribution of Human Papillomavirus in Genital Warts of Korean Men

Prevalência de Condiloma Acuminado no Município de Campo Grande – Mato Grosso do Sul, no Período de 2006 a 2009

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