Natural history of helicobacter pylori infection from infancy to adulthood: A 21-year follow-up cohort study

Malaty, Hoda M.; Graham, David Y.; Elkasabany, Abdalla; Reddy, S.; Srinivasan, S.R.; Gs, Berenson

doi:10.1016/s0016-5085(08)80628-2

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“…A 21‐year retrospective follow‐up study of young children in Louisiana was conducted to examine changes in H. pylori seroprevalence 18 . Of 225 children studied at 1–3 years of age, 8% had H. pylori antibodies, increasing to 34% when re‐examined at 18–20 years of age.…”

Section: Natural History and Epidemiology Of H Pylori Infectionmentioning

confidence: 99%

Natural history and epidemiology ofHelicobacter pyloriinfection

2002

Aliment Pharmacol Ther

357

136

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Helicobacter pylori is a common bacterium infecting about half the world's population. It is causally linked with a diverse spectrum of gastrointestinal clinical disorders including peptic ulcer disease, gastric cancer, and gastric MALT lymphoma. The principal reservoir is the human stomach, and transmission probably occurs by person‐to‐person passage. Prevalence rates are generally much higher in developing countries compared to developed countries, although there are subgroups within many regions with higher H. pylori prevalence than in the general population. The prevalence of H. pylori varies by geographical location, ethnic background, socioeconomic conditions, and age. Recent studies suggest decreasing prevalence in developed countries or those with rapidly improving socioeconomic conditions. Comparative studies of the two fully sequenced H. pylori genomes are providing understanding of its large genetic diversity and bacterial virulence factors. The discovery of the type IV secretion system in H. pylori and its role in translocation of the CagA protein from the bacterial cell into the host epithelial cell provides insight into how host–bacterial interaction may lead to host disease. Cytokine promoter polymorphisms are determinants important in host gastric acid secretion status. Understanding the changing trends in H. pylori epidemiology, details of its transmission pathways, and the bacterial and host determinants leading to gastroduodenal disease remain the challenges in this area. Global epidemiological studies, advances in technology, and medical interventions have converged to help clarify the mechanisms of interaction between this ubiquitous micro‐organism and its host that result in its diverse clinical manifestations.

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Section: Natural History and Epidemiology Of H Pylori Infectionmentioning

confidence: 99%