1995
DOI: 10.1001/jama.1995.03530070052029
|View full text |Cite
|
Sign up to set email alerts
|

Natural History of HIV-1 Cell-Free Viremia

Abstract: The stability of virion-associated HIV-1 RNA levels suggests that an equilibrium between HIV-1 replication rate and efficacy of immunologic response is established shortly after infection and persists throughout the asymptomatic period of the disease. Thus, defective immunologic control of HIV-1 infection may be as important as the viral replication rate for determining AIDS-free survival. Because individual steady-state levels of viremia were established soon after infection, HIV-1 RNA levels may be useful ma… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
63
1

Year Published

1995
1995
2010
2010

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 163 publications
(66 citation statements)
references
References 28 publications
2
63
1
Order By: Relevance
“…9 In men, viral load after HIV-1 seroconversion is an independent predictor of the risk of progression to the acquired immunodeficiency syndrome (AIDS). [10][11][12][13][14][15][16] Viral load is the basis for the current guidelines for the initiation of antiretroviral therapy, which apply uniformly to women and men. 17,18 The relation between the initial viral load and the risk of progression to AIDS in women has not been studied.…”
Section: Resultsmentioning
confidence: 99%
“…9 In men, viral load after HIV-1 seroconversion is an independent predictor of the risk of progression to the acquired immunodeficiency syndrome (AIDS). [10][11][12][13][14][15][16] Viral load is the basis for the current guidelines for the initiation of antiretroviral therapy, which apply uniformly to women and men. 17,18 The relation between the initial viral load and the risk of progression to AIDS in women has not been studied.…”
Section: Resultsmentioning
confidence: 99%
“…After suppressive therapy failed 0.8 0.0-1.5 CDC, 58 de Wolf et al, 59 Mellors et al, 60 Ioannidis et al, 61 Keet et al, 62 O'Brien et al, 63 Spijkerman et al, 64 Henrard et al, 65 Sabin et al 66,67 After suppressive therapy failed and onset of AIDS 65 Sabin et al, 67 Vlahov et al, 73 Hughes et al, 74 Marschner et al, 76 Brun-Vezinet et al, 77 Coombs et al, 78 GalettoLacour et al, 79 Katzenstein et al, 80 Mellors et al, 81 Montaner et al, 82 Pedersen et al, 85 Phillips et al, 86,87 Welles et al, 88 Yerly et al, 89 Chêne et al, 90 Loveday and Hill 91 44 Mocroft et al, 45 Rhone et al, 46 Cohen Stuart et al, 47 Hammer et al, 48 Maher et al, 49 Raboud et al, 55 Deeks et al, 57 Lucas et al, 68 Bonfanti et al, 70,112 Valdez et al, 71 Butcher et al, 92 Guardiola et al, 93 Casado et al, 94 d'Arminio Monforte et al, 95 Kirk et al, 96 Roca et al, 97,98 van Roon et al, …”
Section: Patient Populationmentioning
confidence: 99%
“…It is unclear how long this virologic set point is maintained. Some prospective studies of serial determinations of virus load have shown stability of virus levels throughout the course of HIV infection [4,11]. A few more recent studies noted a lack of longterm viral set point [5,7,12,13]; however, only two of these studies followed virus load from HIV seroconversion [5,7].…”
mentioning
confidence: 99%