1997
DOI: 10.1016/s0091-6749(97)70270-7
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Natural history of Hymenoptera venom sensitivity in adults

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Cited by 118 publications
(90 citation statements)
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“…IgEs are labile in serum with a half-life measured in days. Despite this fact, serum levels of antibody against a unique, pointed allergen challenge (without repeated challenge) have a half-life of 3-7 years (16,17) due to the long life of antibody-producing plasma cells. In addition, persons exhibiting high levels of IgE early in life are highly prone to developing adult atopic allergies (particularly respiratory), indicating that a point measurement of IgE in adulthood is not an unreasonable measure of historical IgE levels (18 -20), a point supported by our data (Table 4).…”
Section: Discussionmentioning
confidence: 99%
“…IgEs are labile in serum with a half-life measured in days. Despite this fact, serum levels of antibody against a unique, pointed allergen challenge (without repeated challenge) have a half-life of 3-7 years (16,17) due to the long life of antibody-producing plasma cells. In addition, persons exhibiting high levels of IgE early in life are highly prone to developing adult atopic allergies (particularly respiratory), indicating that a point measurement of IgE in adulthood is not an unreasonable measure of historical IgE levels (18 -20), a point supported by our data (Table 4).…”
Section: Discussionmentioning
confidence: 99%
“…Early allergic reactions which can be observed in a range from angioedema to anaphylaxis generally occur in the first four hours. Delayed reactions which occur after a few days or weeks may lead to neurologic and vascular events including coagulation disorders, peripheral neuropathy, convulsion, vasculitis, skin reactions and serum sickness (6)(7)(8)(9). In our case, an early type of allergic reaction in the form of marked edema and ecchymosis in the penile skin developed in a few hours.…”
Section: Discussionmentioning
confidence: 76%
“…Systemic acute allergic reactions are treated like the other causes of anaphylaxis (7)(8)(9)(10). For protection from bee bites garments with long sleeves should be worn at picnic and rural areas, colored clothing and aromatic odours should be avoided, home and enviromental wastes should be moved away without waiting, formation of bee nests should be prevented with insecticides in areas where bees are found with high numbers (2-4, 7).…”
Section: Discussionmentioning
confidence: 99%
“…13 Patients who have experienced systemic symptoms after a sting are at much greater risk of anaphylaxis on subsequent stings, as compared to patients who have only had large local reactions. The frequency of systemic reactions to stings in children and adults with a history of large local reactions is about 5% to 10%, whereas the risk in patients with previous systemic reactions is between 30% and 70%.…”
Section: Sit For Venom Hypersensitivitymentioning
confidence: 99%