Natural History of Individuals With Asymptomatic Disc Abnormalities in Magnetic Resonance Imaging

Boos, Norbert; Semmer, Norbert K.; Schade, Volker; Gal, Imre; Zanetti, M.; Kissling, R; Buchegger, Niklaus; Hodler, Juerg; Main, Chris J.

doi:10.1097/00007632-200006150-00006

Cited by 191 publications

(97 citation statements)

References 28 publications

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“…(28). The scale has been successfully employed in previous research (29) and has been shown to predict indicators of low-back pain in initially asymptomatic persons (30).…”

Section: Methodsmentioning

confidence: 99%

Time control, catecholamines and back pain among young nurses

Elfering

Grebner²,

Semmer³

et al. 2002

Scand J Work Environ Health

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Elfering A, Grebner S, Semmer NK, Gerber H. Time control, catecholamines and back pain among young nurses. Scand J Work Environ Health 2002;28(6):386-393.Objectives This study had two objectives. First, it addressed concern with the contribution of work stressors and resources to the development of back pain, over and above the influence of biomechanical work factors. Second, using recent models about the role of the sympathetic-adrenal medullar system in musculoskeletal problems as its basis, it tested whether low-back pain is associated with higher levels of catecholamines.Methods Altogether 114 nurses filled out a questionnaire in their first year of practice and again one year later.In addition, in a subsample of 24 nurses studied intensively at follow-up, urinary catecholamines were assessed at noon, before the end of work, in the evening, and at corresponding times on a day off. Daily stressful experiences and daily mood were also recorded. ResultsWith control for baseline pain, biomechanical workload, and other potentially confounding variables, time control at the beginning of the study predicted low-back pain a year later. In the subsample, the epinephrine and norepinephrine levels were higher in those reporting more frequent episodes of back pain, the largest differences occurring at the end of work. In addition, control over stressful events at work was lower in this group.Conclusions Time control is a risk factor for low-back pain among nurses beyond the influence of physical work load. Low control at work may increase the activity of the sympathetic-adrenal medullar system, which seems to play an important role in the development of musculoskeletal pain.

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“…(28). The scale has been successfully employed in previous research (29) and has been shown to predict indicators of low-back pain in initially asymptomatic persons (30).…”

Section: Methodsmentioning

confidence: 99%

Time control, catecholamines and back pain among young nurses

Elfering

Grebner²,

Semmer³

et al. 2002

Scand J Work Environ Health

Self Cite

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“…[7][8][9][10][11][12] However, these articles have mainly assessed the influence of genetics or environmental variables on the progression of overall disk degeneration in individual subjects, without focusing on the possible association of sequential degeneration of individual disks with annular tears.…”

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confidence: 99%

Association between Annular Tears and Disk Degeneration: A Longitudinal Study

Sharma¹,

Pilgram²,

Wippold³

2009

AJNR Am J Neuroradiol

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“…The authors went further to state that given the high prevalence of these findings and of back pain, the discovery by MRI of bulges or protrusions in people with low back pain may frequently be coincidental. In another study 19 , which tracked the natural history of individuals with asymptomatic disc abnormalities in magnetic resonance imaging the authors stated that the high rate of lumbar disc alterations recently detected in asymptomatic individuals by magnetic resonance imaging demands reconsideration of a pathomorphology-based explanation of low back pain and sciatica. .…”

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confidence: 99%

The biochemical origin of pain – Proposing a new law of pain: The origin of all pain is inflammation and the inflammatory response. Part 1 of 3 – A unifying law of pain

Omoigui¹

2007

Medical Hypotheses

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We are proposing a unifying theory or law of pain, which states: The origin of all pain is inflammation and the inflammatory response. The biochemical mediators of inflammation include cytokines, neuropeptides, growth factors and neurotransmitters. Irrespective of the type of pain whether it is acute or chronic pain, peripheral or central pain, nociceptive or neuropathic pain, the underlying origin is inflammation and the inflammatory response. Activation of pain receptors, transmission and modulation of pain signals, neuro plasticity and central sensitization are all one continuum of inflammation and the inflammatory response. Irrespective of the characteristic of the pain, whether it is sharp, dull, aching, burning, stabbing, numbing or tingling, all pain arise from inflammation and the inflammatory response. We are proposing a re-classification and treatment of pain syndromes based upon their inflammatory profile. Treatment of pain syndromes should be based on these principles:1. Determination of the inflammatory profile of the pain syndrome 2. Inhibition or suppression of production of the appropriate inflammatory mediators e.g. with inflammatory mediator blockers or surgical intervention where appropriate 3. Inhibition or suppression of neuronal afferent and efferent (motor) transmission e.g. with anti-seizure drugs or local anesthetic blocks Modulation of neuronal transmission e.g. with opioid medicationAt the L.A. Pain Clinic, we have successfully treated a variety of pain syndromes by utilizing these principles. This theory of the biochemical origin of pain is compatible with, inclusive of, and unifies existing theories and knowledge of the mechanism of pain including the gate control theory, and theories of pre-emptive analgesia, windup and central sensitization.

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Natural History of Individuals With Asymptomatic Disc Abnormalities in Magnetic Resonance Imaging

Cited by 191 publications

References 28 publications

Time control, catecholamines and back pain among young nurses

Time control, catecholamines and back pain among young nurses

Association between Annular Tears and Disk Degeneration: A Longitudinal Study

The biochemical origin of pain – Proposing a new law of pain: The origin of all pain is inflammation and the inflammatory response. Part 1 of 3 – A unifying law of pain

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