2022
DOI: 10.1186/s12876-022-02454-z
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Natural history of intracholecystic papillary neoplasm (ICPN): a rare case of ICPN whose natural history was closely followed by ultrasound

Abstract: The natural history of intracholecystic papillary neoplasm (ICPN), especially the speed of growth from small benign to a carcinomatous lesion, is quite unrevealed. Here, we report an extremely rare case of ICPN, in which the papillary lesion was observed transforming from small and benign to malignant using abdominal ultrasound (AUS) over 2 years during routine health checks. A 44-year-old man underwent a routine health check-up. The initial AUS showed a small sessile polyp in the gallbladder, which enlarged s… Show more

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Cited by 8 publications
(12 citation statements)
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“…The 5-year survival rate for ICPN is 60% if including invasive carcinoma and 78% if noninvasive. 10,11 In contrast, the 5-year survival rate for gallbladder adenocarcinoma is 30%. The difference in prognosis may be due to their endophytic nature of growth nature causing symptoms earlier in the natural course and thereby earlier diagnosis or an inherent more indolent biology.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…The 5-year survival rate for ICPN is 60% if including invasive carcinoma and 78% if noninvasive. 10,11 In contrast, the 5-year survival rate for gallbladder adenocarcinoma is 30%. The difference in prognosis may be due to their endophytic nature of growth nature causing symptoms earlier in the natural course and thereby earlier diagnosis or an inherent more indolent biology.…”
Section: Discussionmentioning
confidence: 99%
“…It is found in 0.4% of GB specimens. 10,11 They are more common in women, mainly in the 5 th and 6 th decades. 11 It may be an incidental finding or can present with upper abdominal pain.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…ICPN is a rather uncommon premalignant neoplasm. Typically, it presents as an intermittent RUQ pain with a detectable mass (≥1 cm) on conventional imaging such as U/S or contrast CT. Up to 50% of ICPN cases are detected incidentally, and approximately 10% are missed in imaging studies [ 6 ]. Due to the rare occurrence of this lesion, current literature has only identified a few risk factors that may lead to the development of this neoplasm.…”
Section: Discussionmentioning
confidence: 99%
“…This suggestion was recently supported by an ultrasound followup of a patient who had a papillary lesion of the gallbladder that evolved from benign to malignant within a 2-year period and which displayed histological criteria of ICPN upon resection. 32 The occurrence of ICPN is less clearly correlated with the presence of cholelithiasis, but ICPNs are often detected in combination with pancreaticobiliary maljunction. 33 PGA is another precursor of GBC.…”
Section: Gallbladder Cancermentioning
confidence: 99%