Natural history of optic pathway tumors in children with neurofibromatosis type 1: A longitudinal study

Listernick, Robert; Charrow, Joel; Greenwald, Mark J.; Mets, Marilyn B.

doi:10.1016/s0022-3476(94)70122-9

Cited by 494 publications

(303 citation statements)

References 9 publications

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“…Second, gliomas predominate in the optic pathway as opposed to the cerebellum, where they more commonly arise in the general population (Listernick et al, 1995). Third, NF1-associated optic gliomas arise at a younger age (mean ¼ 4.5-5.8 years) than in the general population (mean ¼ 5.1-12 years) (Stern et al, 1980;Listernick et al, 1989Listernick et al, , 1994Singhal et al, 2002;Thiagalingam et al, 2004). Fourth, unlike their sporadic counterparts, NF1-associated optic gliomas are less likely to progress and require treatment (Listernick et al, 1997).…”

Section: Neurofibromatosis-1 As a Model Systemmentioning

confidence: 99%

The ecology of brain tumors: lessons learned from neurofibromatosis-1

Pong

Gutmann

2010

Oncogene

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Traditionally, cancer studies have primarily focused on mutations that activate growth or survival pathways in susceptible pre-neoplastic/neoplastic cells. However, recent research has revealed a critical role for nonneoplastic cells within the tumor microenvironment in the process of cancer formation and progression. In addition, the existence of regional and developmental variations in susceptible cell types and supportive microenvironments support a model of tumorigenesis in which the dynamic symbiotic relationship between neoplastic and non-neoplastic cell types dictate where and when cancers form and grow. In this review, we highlight advances in neurofibromatosis type 1 (NF1) genetically engineered mouse brain tumor (glioma) modeling to reveal how cellular and molecular heterogeneity in both the pre-neoplastic/ neoplastic and non-neoplastic cellular compartments contribute to gliomagenesis and glioma growth.

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Section: Neurofibromatosis-1 As a Model Systemmentioning

confidence: 99%

The ecology of brain tumors: lessons learned from neurofibromatosis-1

Pong

Gutmann

2010

Oncogene

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“…2 There is a 15-20% incidence of OPG in patients with NF1. 3,4 The clinical presentation of OPG is quite variable depending on the tumour location and extent. [4][5][6][7] Many patients are asymptomatic.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 The clinical presentation of OPG is quite variable depending on the tumour location and extent. [4][5][6][7] Many patients are asymptomatic. 4,5 Patients with tumours within the orbit present with proptosis, strabismus, and/or visual loss.…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6][7] Many patients are asymptomatic. 4,5 Patients with tumours within the orbit present with proptosis, strabismus, and/or visual loss. Intracranial OPG can present with visual and endocrine impairment.…”

Section: Introductionmentioning

confidence: 99%

“…4,5 As an example; Figure 1 shows a representative MRI cut from a patient the author (LMK) has followed for 8 years. This patient's clinical findings and imaging results have remained unchanged during this whole period of observation.…”

Section: Introductionmentioning

confidence: 99%

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Optic glioma warranting treatment in children

Kaufman

Doroftei

2006

Eye

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Purpose To describe cases of optic pathway glioma (OPG) warranting treatment in children. Methods This is a retrospective review of pediatric patients treated for OPG. The clinical data and imaging studies were obtained from the medical records and radiology files of patients seen at the Pediatric NeuroOphthalmology Clinic at the University of Illinois, Chicago and the private office of the author (LMK). Results A total of seven cases with an age range of 3-48 months at presentation were reviewed. Three of the patients were also ultimately diagnosed with neurofibromatosis type 1. Presenting symptoms included proptosis, decreased vision, gaze deficit, and nystagmus. Four patients underwent biopsies that confirmed OPG. Six of the patients were treated with intravenous chemotherapy, with three patients requiring a second chemotherapy cycle. One patient was successfully treated with an en-bloc optic nerve excision. Two patients underwent unilateral enucleation owing to globe complications. Conclusion Although benign tumours, OPG can behave very aggressively in young children. Both chemotherapy and en-bloc excision can be employed for treatment.

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Visual Function and Optic Pathway Glioma: A Critical Response—Reply

Parsa¹

2013

JAMA Ophthalmol

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Natural history of optic pathway tumors in children with neurofibromatosis type 1: A longitudinal study

Cited by 494 publications

References 9 publications

The ecology of brain tumors: lessons learned from neurofibromatosis-1

The ecology of brain tumors: lessons learned from neurofibromatosis-1

Optic glioma warranting treatment in children

Visual Function and Optic Pathway Glioma: A Critical Response—Reply

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