Natural History of Organ Failure in Acute Pancreatitis

McKay, Colin; Buter, Anton

doi:10.1159/000070078

Cited by 72 publications

(45 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mortality in the absence of organ failure is 0 (50,66,68,83), with single organ failure is 3% (range 0-8%) (66,83,163), with multisystem organ failure 47% (range 28-69%) (48,66,68,83,120,163,164).…”

Section: Overview Of Acute Pancreatitismentioning

confidence: 99%

“…Although older literature suggested that 80% of deaths occur after several weeks of illness as a result of infected necrosis, more recent surveys have shown considerable variation with several reports showing a reasonably even distribution of early deaths (within 1-2 wk) versus later deaths (46,72,76,150,151,163), a few showing the majority of deaths within the first 2 wk (67,75), and others showing the majority of deaths after the first 2 wk (59,89,135). These variations reflect a variety of influences including percentage of very ill patients referred to a reporting hospital compared to patients admitted directly.…”

Section: Overview Of Acute Pancreatitismentioning

confidence: 99%

“…Several reports have pointed out that patients with organ failure at admission have a higher mortality than those who do not experience organ failure at admission (50,61,69,71,72,83,163). The progression of single organ failure to multisystem organ failure is a major determinant in the high mortality associated with organ failure at admission (83).…”

Section: Diagnostic Guideline I: Look For Risk Factors Of Severity Atmentioning

confidence: 99%

See 2 more Smart Citations

Practice Guidelines in Acute Pancreatitis

Banks

Freeman

2006

Am J Gastroenterology

1,677

980

View full text Add to dashboard Cite

Section: Overview Of Acute Pancreatitismentioning

confidence: 99%

Section: Overview Of Acute Pancreatitismentioning

confidence: 99%

Section: Diagnostic Guideline I: Look For Risk Factors Of Severity Atmentioning

confidence: 99%

See 1 more Smart Citation

Practice Guidelines in Acute Pancreatitis

Banks

Freeman

2006

Am J Gastroenterology

1,677

980

View full text Add to dashboard Cite

“…Furthermore, the abscess appears later in evolution, usually after four to six weeks of onset and contains no pancreatic necrosis 7,11,46 .…”

Section: Collections and Pancreatic Abscessmentioning

confidence: 99%

“…About 20% to 40% of patients with pancreatic necrosis develop infection, and 24% after one week and 72% after three weeks 10,46 , with mortality in these cases up to 50% 59,66 .…”

Section: Introductionmentioning

confidence: 99%

Quando e como tratar as complicações na necrose pancreática infectada

Silva¹,

Pacheco-Junior²,

Moricz³

et al. 2010

ABCD, arq. bras. cir. dig.

View full text Add to dashboard Cite

-Introduction -Acute pancreatitis is presented in its severe form between 10% and 15% of cases and is associated with high mortality. In the initial phase, evolution characterized by the onset of organ dysfunction and subsequently by the presence of pancreatic necrosis and its complications. Methods -It was performed a literature review with consultations in the following databases: PubMed, SciELO, Lilacs. Headings used were the following: acute pancreatitis, infection, pancreatic necrosis. Conclusion -The treatment of pancreatic necrosis, despite the advent of modern methods and techniques, is still challenging. Because of the multiplicity of aspects that may take the examination of each case, in view of the extent, severity and location of facilities within a patient's care, the treatment should be individualized for each case.RESUMO -Introdução -A pancreatite aguda se apresenta na sua forma grave entre 10% e 15% dos casos e está associada com alta mortalidade. Na fase inicial da evolução caracteriza-se pelo aparecimento de disfunções orgânicas e posteriormente pela presença de necrose pancreática e suas complicações. Método -Foi realizada revisão da literatura com consultas feitas nas seguintes bases de dados: Pubmed, Scielo, Lilacs. Os descritores cruzados foram os seguintes: pancreatite aguda, infecção, necrose pancreática. Conclusão -O tratamento da necrose pancreática, apesar do advento de modernos métodos e técnicas, ainda continua desafiador. Devido à multiplicidade de aspectos que pode assumir, a análise de cada caso, tendo em vista a extensão, gravidade e meios existentes no local de atendimento do paciente, é que deverá orientar o tratamento possível, sendo ele sempre individualizado a cada caso.

show abstract

Early intra‐abdominal hypertension: A reliable bedside prognostic marker for severe acute pancreatitis

et al. 2020

View full text Add to dashboard Cite

Background and Aim Severe acute pancreatitis (SAP) is commonly associated with intra‐abdominal hypertension (IAH). This acute increase of intra‐abdominal pressure (IAP) may be attributed to early organ dysfunction, leading to an increased morbidity and mortality. To assess the incidence of raised IAH and its correlation with other prognostic indicators and various outcomes in SAP. Methods and Results This was a prospective observational study in patients of SAP between July 2009 and December 2010. All patients of SAP who were admitted to the hospital within 2 weeks of onset of pain were included in the study. A total of 35 patients with SAP were included in the study. Among these, 25 (71.4%) were males. All our patients had raised IAP; however, IAH was present in 51.4% (18/35). Patients with IAH were found to have a higher APACHE II score (88.9 vs 5.9%; P < 0.001), infectious complications (72.2 vs 5.9%; P < 0.001), circulatory failure (88.9 vs 0%; P < 0.001), and respiratory failure (100 vs 41.2%; P < 0.001). All the eight (22.8%) patients who succumbed to sepsis had IAH. Patients with IAH were found to have a significantly longer intensive care unit (ICU) stay (17.72 vs 12.29 days) and in‐hospital stay (24.89 vs 12.29 days). Conclusion IAH is a good negative prognostic marker in SAP, seen in up to 51.4%. IAH was found to have a significant negative impact on the outcome in terms of increased mortality, morbidity, in‐hospital stay, and ICU stay among the patients of SAP.

show abstract

Natural History of Organ Failure in Acute Pancreatitis

Cited by 72 publications

References 17 publications

Practice Guidelines in Acute Pancreatitis

Practice Guidelines in Acute Pancreatitis

Quando e como tratar as complicações na necrose pancreática infectada

Early intra‐abdominal hypertension: A reliable bedside prognostic marker for severe acute pancreatitis

Contact Info

Product

Resources

About