Natural History of Retinal Pigment Epithelial Detachments in Age-related Macular Degeneration

Poliner, Lon S.; Olk, R. Joseph; Burgess, Dean B.; Gordon, Mae E.

doi:10.1016/s0161-6420(86)33703-5

Cited by 82 publications

(40 citation statements)

References 10 publications

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“…Subretinal exudates also decreased in 8 eyes. Spontaneous regression has been reported to occur in approximately 20% of patients with ARMD (Bressler et al 1988a(Bressler et al , 1988bPoliner et al 1986;Chandra et al 1974), so the outcome of the clinical series reported here is clearly better compared to the natural progression of the disease. The patients in our study who showed regression or complete disappearance of CNV had relatively small size and little involvement of the macula and CNV within one-half the optic disk diameter from the foveola.…”

Section: Discussionmentioning

confidence: 77%

Pars plana vitrectomy for regression of choroidal neovascularization with age‐related macular degeneration

Ikeda

Sawa

Koizumi

et al. 2000

Acta Ophthalmologica Scandinavica

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ABSTRACT.Objective: In age-related macular degeneration, the posterior vitreous surface often remains attached to a higher degree than expected for the patient's age, suggesting the involvement of the posterior vitreous membrane in the pathophysiology of choroidal neovascularization. Thus, we performed simple pars plana vitrectomy and artificial posterior vitreous detachment in order to induce regression of choroidal neovascularization.

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Section: Discussionmentioning

confidence: 77%

Pars plana vitrectomy for regression of choroidal neovascularization with age‐related macular degeneration

Ikeda

Sawa

Koizumi

et al. 2000

Acta Ophthalmologica Scandinavica

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“…S erous pigment epithelium detachment (SPED) in age-related macular degeneration (AMD) has been associated with choroidal neovascularisation (CNV) with increased risk of visual loss, in from 24% to 67% of cases (Teeters & Bird 1973;Meredith et al 1979;Braunstein & Gass 1979;Klein et al 1980;Gass 1984;Casswell et al 1985;Poliner et al 1986;Elman et al 1986;Hartnett et al 1992).…”

mentioning

confidence: 99%

Hyperfluorescence associated with serous retinal pigment epithelial detachment on indocyanine green angiography

Parodi

Saviano

Bondel

et al. 2000

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: Indocyanine green angiography has been reported to improve detection and delineation of occult choroidal neovascularisation in serous pigment epithelium detachment in age-related macular degeneration. The study aims to evaluate the visual acuity results of eyes affected by serous pigment epithelium detachment in age-related macular degeneration, having had indocyanine greendirected laser photocoagulation, and to correlate them to the pattern of serous pigment epithelium detachment on indocyanine green angiography. Methods: Thirty-four eyes of 31 patients affected by serous pigment epithelium detachment in age-related macular degeneration were prospectively considered. Each patient underwent an ophthalmological examination including fluorescein and indocyanine green angiography one day before, and 6 weeks, 3 months, 6 months, 9 months, 12 months and 24 months after krypton-laser treatment. The serous pigment epithelium detachment was classified in the late-phases angiograms as either hypofluorescent, isofluorescent or hyperfluorescent comparing the fluorescence of the serous pigment epithelium detachment with the choroidal background fluorescence. Results: The indocyanine green-guided laser treatment was associated with a temporary stabilization and a long-term progressive reduction of visual acuity: after 24 months visual acuity improved in 2.9%, stabilized in 26.5% and worsened in 70.5% of cases. Serous pigment epithelium detachment presenting a pretreatment hyperfluorescence had a final visual acuity of 0.06, with subfoveal choroidal neovascularisation development in 100% of cases, whereas serous pigment epithelium detachment presenting a pretreatment hypofluorescence and isofluorescence showed a final visual acuity of 0.12, with subfoveal choroidal neovascularisation development in 43.5% of eyes, with statistically significant difference. Conclusion: Overall visual acuity decreases with time after indocyanine greenguided laser treatment of choroidal neovascularisation in serous pigment epithelium detachment, and serous pigment epithelium detachment becoming hyperfluorescent in the late-phases of indocyanine green angiography has the worst functional outcome.Key words: indocyanine green angiography -hyperfluorescence -serous retinal pigment epithelial detachment.

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“…It is suggested that older patients who exhibit larger and more elevated PEDs are at a higher risk for complications (17) . The outcome of the natural history of 46 eyes with avascular serous PED demonstrated visual acuity of 20/200 or worse in 33% of the assessed cases (18) . The PED treatment results with anti-angiogenic drugs are variable; however, they indicate that the lesion stabilizes with the use of ranibizumab (Lucentis®) or bevacizumab (Avastin®), particularly in the cases with neovascular component.…”

Section: Discussionmentioning

confidence: 95%

Grid laser photocoagulation in the treatment of serous avascular pigment epithelial detachment in age-related macular degeneration

Filho¹,

Moreira²,

Malafaia³

et al. 2014

Arquivos Brasileiros De Oftalmologia

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Purpose: Describe the outcomes of thermal laser photocoagulation in three cases of retinal pigment epithelium detachment associated to age-related macular degeneration. Methods: Three patients with avascular retinal pigment epithelium detachment were treated with green diode laser photocoagulation. Mild macular grid laser application, similar to the treatment of diabetic macular edema was performed after an unsuccessful intravitreal anti-angiogenic treatment. Results: After one year of the laser treatment, two cases reached anatomic resolution, with complete absorption of sub-epithelium serum fluid and improvement of the visual acuity. There was stability of the visual acuity and sub-epithelium fluid reduction, which, however, was partial in the third case. No complications related to the treatment occurred until the conclusion of this study. Conclusions: Macular photocoagulation in grid pattern produced regression of avascular serous pigment epithelium detachment associated with age-related macular degeneration in a short follow-up period. Although long term prospecti ve studies with an increased sample are necessary, it is a method that can be applied in selected patients, with absence of sub-retinal neovascularization or sub-epithelium fibrovascular component.

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Natural History of Retinal Pigment Epithelial Detachments in Age-related Macular Degeneration

Cited by 82 publications

References 10 publications

Pars plana vitrectomy for regression of choroidal neovascularization with age‐related macular degeneration

Pars plana vitrectomy for regression of choroidal neovascularization with age‐related macular degeneration

Hyperfluorescence associated with serous retinal pigment epithelial detachment on indocyanine green angiography

Grid laser photocoagulation in the treatment of serous avascular pigment epithelial detachment in age-related macular degeneration

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