Natural history of simple renal cysts: longitudinal CT-based evaluation

Wentland, Andrew L.; Nystrom, Jered; Lubner, Meghan G.; Mao, Lu; Abel, E. Jason; Pickhardt, Perry J.

doi:10.1007/s00261-022-03421-8

Cited by 3 publications

(5 citation statements)

References 27 publications

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“…The prevalence of kidney cysts increases with age in the general population, and asymptomatic simple cysts are considered benign. [3][4][5][6] However, a large cross-sectional study of living donor candidates found that one kidney cyst was present in 39% of younger candidates (< 50 years old) and in 63% of older candidates (≥50 years old), and those a Coefficients represent the difference in single-kidney eGFR increase for the exposure group compared to the reference group. b Coefficients represent the relative risk of total eGFR loss >40% for the exposure group compared to the reference group.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of kidney cysts increases with age in the general population, and asymptomatic simple cysts are considered benign 3–6 . However, a large cross‐sectional study of living donor candidates found that one kidney cyst was present in 39% of younger candidates (< 50 years old) and in 63% of older candidates (≥50 years old), and those with incidental kidney cysts were more likely to have hypertension and had higher eGFR and microalbuminuria even after accounting for age 7 .…”

Section: Discussionmentioning

confidence: 99%

“…However, our analysis is limited by its reliance on a surrogate 6‐month measure for donor kidney function outcomes given limited longer term follow up among donors available for analysis. Although this surrogate outcome has been previously validated in a general donor population, 12 it is possible that cysts exert a clinically meaningful impact in the long term, given their potential to grow in size and number, 3–5 and that use of a surrogate outcome fails to capture the long‐term impact of cysts on donor kidney function and graft survival. Additionally, since living kidney donors represent a subset of well‐screened individuals without significant risk for the development of ESRD over the long term, conclusions about the impact of cysts on kidney function ought not be extrapolated to other contexts.…”

Section: Discussionmentioning

confidence: 99%

“…In the general population, the presence of asymptomatic simple kidney cysts is typically understood to be benign. [3][4][5][6] While cysts are commonly considered to be a feature of advancing age, it is also plausible that the presence of kidney cysts provides additional information about donor quality and risk of adverse kidney outcomes given that the presence of cysts is more frequent in individuals with other early markers of kidney disease, such as albuminuria, hypertension, and hyperfiltration. 7 KDIGO 2017 guidelines recommend permitting living kidney donation in the presence of low risk kidney cysts, although this recommendation is based on limited data.…”

Section: Introductionmentioning

confidence: 99%

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Association between donor kidney cysts and donor and recipient outcomes after living donor kidney transplantation

Emmons,

Adler,

Sandoval

et al. 2024

Clinical Transplantation

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IntroductionIncidental kidneys cysts are typically considered benign, but the presence of cysts is more frequent in individuals with other early markers of kidney disease. We studied the association of donor kidney cysts with donor and recipient outcomes after living donor kidney transplantation.MethodsWe retrospective identified 860 living donor transplants at our center (1/1/2011–7/31/2022) without missing data. Donor cysts were identified by review of pre‐donation CT scan reports. We used linear regression to study the association between donor cysts and 6‐month single‐kidney estimated glomerular filtration rate (eGFR) increase, and time‐to‐event analyses to study the association between donor cysts and recipient death‐censored graft failure.ResultsAmong donors, 77% donors had no kidney cysts, 13% had ≥1 cyst on the kidney not donated, and 11% only had cysts on the donated kidney. In adjusted linear regression, cysts on the donated kidney and kidney not donated were not significantly associated with 6‐month single‐kidney eGFR increase. Among transplants, 17% used a transplanted kidney with a cyst and 6% were from donors with cysts only on the kidney not transplanted. There was no association between donor cyst group and post‐transplant death‐censored graft survival. Results were similar in sensitivity analyses comparing transplants using kidneys with no cysts versus 1–2 cysts versus ≥3 cysts.ConclusionsKidney cysts in living kidney donors were not associated with donor kidney recovery or recipient allograft longevity, suggesting incidental kidney cysts need not be taken into account when determining living donor candidate suitability or the laterality of planned donor nephrectomy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association between donor kidney cysts and donor and recipient outcomes after living donor kidney transplantation

Emmons,

Adler,

Sandoval

et al. 2024

Clinical Transplantation

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“…Macroscopically, an increase in the number of cysts and larger cysts in the elderly was observed [25,26]. While an incidence of 14.1% was reported in the 50–59 year group, the rate more than doubled in those aged 70 and older [27].…”

Section: Histological Alterations Accompanied With Ageingmentioning

confidence: 97%

Renal function in very old critically ill patients

Perschinka,

Boyer,

Forni

et al. 2023

Current Opinion in Critical Care

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Purpose of review Current demographic change leads to higher number of elderly patients admitted to an ICU. Among other organs also the kidneys show age-related changes, which are associated with a decline in various aspects of renal function. The purpose of this review is to provide an overview of structural and functional changes in elderly and also to specifically address the increased risk of acute kidney injury (AKI) in this population. Recent findings Ageing in the kidneys is affected by many different factors, such as low grade chronic inflammation, called inflammageing, and various comorbidities. Nevertheless, a decrease of glomerular filtration rate (GFR) occurs independent of the presence of comorbidities and a steady decline of GFR has been reported in both healthy men and women. Pharmacodynamic of many drugs is altered by these changes. Additionally the rate of diuretic resistance appears to be increased. The cause of AKI occurrence in older age is, multifactorial and includes preventable triggers (hypovolemia, hypotension, nephrotoxins) as well as changes associated with aging. Summary Age-related alterations of the kidneys were found at microscopic and macroscopic levels of the cell. These changes lead to a reduced renal reserve and subsequently to an increased vulnerability of aged kidneys when an additional stressor is added. Age is an independent risk factor for developing AKI. Physicians should take into account the altered renal function in elderly patients and take renal protective measures at an early stage.

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Chirurgia laparoscopică a rinichiului

Chirnicinîi

2023

InterConf+

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Importanța acestui studiu constă în prezentarea eficacității chirurgiei laparoscopice a rinichiului în tratamentul chistului renal față de intervențiile urologice deschise. Actualitatea studiului se datorează potențialului foarte înalt a metodelor laparoscopice în tratamentul chisturilor renale, care prezintă avantaje mari atât față de metodele de puncție, cât și față de intervențiile deschise, laparoscopia devenind un domeniu major în chirurgia urologică.

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Natural history of simple renal cysts: longitudinal CT-based evaluation

Cited by 3 publications

References 27 publications

Association between donor kidney cysts and donor and recipient outcomes after living donor kidney transplantation

Association between donor kidney cysts and donor and recipient outcomes after living donor kidney transplantation

Renal function in very old critically ill patients

Chirurgia laparoscopică a rinichiului

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