Natural history of the aortic root in Tetralogy of Fallot after repair

Kim, Yuli Y.; Geisinger, Max; Bhamare, Tanmay; Wasserman, Melissa; Min, Jungwon; Goldmuntz, Elizabeth

doi:10.1016/j.ijcchd.2021.100092

Cited by 3 publications

(1 citation statement)

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“…The specific situation here is the underlying pathological development of the heart in the tetralogy of Fallot [ 41 ]. Due to the disproportional embryological septation of the conotruncus, there is a significant difference in the size of the aorta and the PA (the PA being smaller and the aorta bigger) not only prenatally/at birth, but this frequently persists throughout life, even despite surgical interventions and different hemodynamic situations years later [ 42 , 43 , 44 ]. This was also confirmed by our study, where the Ao asc diameter was greater not only compared to NORMAL but also compared to PAH-CHD patients.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Artery Dilatation Due to Pressure or Volume Overload in Congenital Heart Disease

Kaldararova,

Bobocka,

Kantorova

et al. 2024

JCM

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Background: Pulmonary artery dilatation is described mostly in association with pulmonary hypertension. Patients/Methods: Study analysis: 60 patients with pulmonary arterial hypertension in congenital heart disease (PAH-CHD); 64 with repaired tetralogy of Fallot/pulmonary regurgitation (rTOF/PR); and 80 healthy (NORMAL). Measured were: main pulmonary artery (MPA) diameter and MPA/ascending aorta (Ao asc) ratio, by echocardiography (ECHO) and computer tomography or magnetic resonance imaging (CT/MRI). Results: In MPA diameter, significant differences between PAH-CHD, rTOF/PR, and NORMAL were found (median): 37 vs. 27 vs. 21 mm (p < 0.0001). In MPA/Ao asc ratio, there was a difference between PAH-CHD and NORMAL (median): 1.3 vs. 0.8 (p < 0.0001), but not between rTOF/PR and NORMAL: 0.74 vs. 0.8 (p = 0.3). Significant MPA dilatation (>40 mm) was present: in PAH-CHD, 35% (ECHO) and 76.9% (CT/MRI) of patients, while in rTOF/PR, 3.1% (ECHO) and 7.8% (CT/MRI). Severe MPA dilatation (>50 mm) occurred only in PAH-CHD: 16.7% (ECHO) and 31.4% (CT/MRI), while not in rTOF/PR. There was a significant correlation between ECHO and CT/MRI measurements, but ECHO was underestimated in all parameters. Conclusions: MPA dilatation due to pressure overload is more frequent and more severe; volume overload also leads to MPA dilatation but is less severe. The MPA/Ao asc ratio is not reliable for MPA dilatation estimation in rTOF/PR.

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