Natural human IL-1β exhibits regulatory actions on human bone-derived cells invitro

Evans, DB; Bunning, R.A.D.; Damme, Jozef Van; Russell, R. G. G.

doi:10.1016/0006-291x(89)92243-2

Cited by 30 publications

(9 citation statements)

References 30 publications

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“…It is clear that other explanations for this decrease must be entertained, and from this perspective, any substances involved in acute phase response and stress reaction are suitable candidates (cytokines, [15][16][17][18] opioid receptors, 19,20 etc.). Further studies are needed to clarify this point.…”

Section: Discussionmentioning

confidence: 99%

Factors other than glucocorticoids are involved in the osteoblast activity decrease caused by tissue injury

Olmos¹,

Amado

Valero³

et al. 2006

Clinical Endocrinology

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The decrease in serum osteocalcin induced by tissue injury is independent of the increase in cortisol secretion triggered by the latter. In addition, another pharmacologically proven effect of cortisol on bone metabolism, OPG inhibition, could not be demonstrated in the first 24 h following surgery, in spite of the physiological increase in endogenous cortisol secretion taking place in this period.

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Section: Discussionmentioning

confidence: 99%

Factors other than glucocorticoids are involved in the osteoblast activity decrease caused by tissue injury

Olmos¹,

Amado

Valero³

et al. 2006

Clinical Endocrinology

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“…Also in rodents, IL-1 promotes bone resorption by stimulating osteoclasts and acts synergistically with TNF and parathyroid hormone Stashenko et al, 1987). The IL-1 desensitizes bone to the action of vitamin D (Evans et al, 1989). The net effect of IL-1 and TNF in mammals is to decrease bone formation and enhance bone resorption, resulting in reduced bone mass and hypercalcemia.…”

Section: Bone and Mineral Metabolismmentioning

confidence: 99%

Monokines in Growth and Development

1991

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Stimulation of the immune system results in a series of metabolic changes that are antagonistic toward growth. Monokines, including interleukin-1, tumor necrosis factor, and interleukin-6, are released from cells of the monocyte-macrophage lineage after recognition of immunogens. They appear to mediate homeorhetic response, which alters the partitioning of dietary nutrients away from growth and skeletal muscle accretion in favor of metabolic processes which support the immune response and disease resistance. These alterations include 1) decreased skeletal muscle accretion due to increased rates of protein degradation and decreased protein synthesis; 2) increased basal metabolic rate resulting in increased energy utilization; 3) use of dietary amino acids for gluconeogenesis and as an energy source instead of for muscle protein accretion; 4) synthesis by the liver of acute phase proteins; 5) redistribution of iron, zinc, and copper within the body due to the hepatic synthesis of metallothionein, ferritin, and ceruloplasmin; (6) impaired accretion of cartilage and bone; and 7) release of hormones such as insulin, glucagon, and corticosterone. These monokines also influence the differentiation of cells. Tumor necrosis factor suppresses the differentiation of myoblasts and adipocytes whereas the chicken monokine myelomonocytic growth factor induces the differentiation of granulocytes.

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“…Furthermore, reports of IL-1β promoting osteoblast proliferation during acute bone repair (Lange et al, 2009) and inducing differentiation of human mesenchymal stem cells into osteoblasts (Sonomoto et al, 2012). Increased DNA synthesis in response to IL-1β in vitro has been observed in osteoblast (Evans et al, 1989) and especially MC3T3-E1 cells (Ikeda et al, 1998). In contrast, however, it has been reported that IL-1β inhibits the stimulation of osteocalcin synthesis and has no influence on proliferation (Taichman et al, 1992).…”

Section: Discussionmentioning

confidence: 80%

Interleukin-1B and 6-Induced Calcium Channel Current Modulation in MC3T3-E1 Osteoblast Cell Line

Kobayashi¹,

Endoh²,

Uchida³

et al. 2015

IJB

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Interleukin-1β (IL-1β) and -6 (IL-6) are inflammatory cytokines that are involved in bone resorption under pathological conditions. The cytokines are also involved in bone remodeling under physiological conditions. Voltage sensitive Ca 2+ channels (VSCCs) serve as crucial mediators of membrane excitability and many Ca 2+ -dependent functions such as growth of bone, regulate proliferation, differentiation, enzyme activity and gene expression. The effects of IL-1β and -6 on VSCCs in osteoblast cell line (MC3T3-E1) were investigated using patch-clamp recording. Our results showed that application of 50 pM-50 nM IL-1β facilitated VSCCs current (I Ca ) carried by Ba 2+ (I Ba ). Application of 50 pM-5 nM IL-6 facilitated I Ba . In contrast, 50 nM IL-6 inhibited I Ba in MC3T3-E1 cells. Treatment with MAPK inhibitor, PD98059, attenuated the 5 nM IL-6-induced facilitation of I Ba . Treatment with STAT3 inhibitor, staffic, attenuated the 50 nM IL-6-induced inhibition of I Ba . Treatment with PD98059 also attenuated the 50 nM IL-6-induced inhibition of I Ba . These results suggest that 5 nM IL-6 facilitates VDCCs involving MAPK pathways. In addition, 50 nM IL-6 inhibits VDCCs involving STAT3 and MAPK pathways in MC3T3-E1 cells.

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Natural human IL-1β exhibits regulatory actions on human bone-derived cells invitro

Cited by 30 publications

References 30 publications

Factors other than glucocorticoids are involved in the osteoblast activity decrease caused by tissue injury

Factors other than glucocorticoids are involved in the osteoblast activity decrease caused by tissue injury

Monokines in Growth and Development

Interleukin-1B and 6-Induced Calcium Channel Current Modulation in MC3T3-E1 Osteoblast Cell Line

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