Natural Humic‐Acid‐Based Phototheranostic Agent

Miao, Zhaohua; Li, Kai; Liu, Pei-Ying; Li, Zhenglin; Yang, Huanjie; Zhao, Qingliang; Chang, Manli; Yang, Qingzhu; Zhen, Liang

doi:10.1002/adhm.201701202

Cited by 39 publications

(17 citation statements)

References 53 publications

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“…In addition, Chen and co‐workers recently reported another PDI‐based contrast agent that can detect the ROS level in the tumor by PA imaging . In addition, chlorin dimers, polypyrrole, polylysine, smart organic NPs, natural humic‐acid‐based nanoagents, and tannic‐acid‐based assemblies have also been explored as contrast agents for PA imaging.…”

Section: Organic Contrast Agentsmentioning

confidence: 99%

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

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Photoacoustic (PA) imaging as a fast‐developing imaging technique has great potential in biomedical and clinical applications. It is a noninvasive imaging modality that depends on the light‐absorption coefficient of the imaged tissue and the injected PA‐imaging contrast agents. Furthermore, PA imaging provides superb contrast, super spatial resolution, and high penetrability and sensitivity to tissue functional characteristics by detecting the acoustic wave to construct PA images. In recent years, a series of PA‐imaging contrast agents are developed to improve the PA‐imaging performance in biomedical applications. Here, recent progress of PA contrast agents and their biomedical applications are outlined. PA contrast agents are classified according to their components and function, and gold nanocrystals, gold‐nanocrystal assembly, transition‐metal chalcogenides/MXene‐based nanomaterials, carbon‐based nanomaterials, other inorganic imaging agents, small organic molecules, semiconducting polymer nanoparticles, and nonlinear PA‐imaging contrast agents are discussed. The applications of PA contrast agents as biosensors (in the sensing of metal ions, pH, enzymes, temperature, hypoxia, reactive oxygen species, and reactive nitrogen species) and in bioimaging (lymph nodes, vasculature, tumors, and brain tissue) are discussed in detail. Finally, an outlook on the future research and investigation of PA‐imaging contrast agents and their significance in biomedical research is presented.

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Section: Organic Contrast Agentsmentioning

confidence: 99%

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

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“…However, most of them still have some drawbacks in clinical application, such as non-degradability, low biosafety and complex synthesis progress. Humic acid (HA) has excellent photothermal conversion ability and photoacoustic (PA) imaging, which is extracted from biochemical humification of animal and plants matter and it has attracted increasing attention in PTT [ 49 ]. Meanwhile, photodynamic therapy (PDT) is another effective strategy for tumor therapy by utilizing the oxygen reactive species (ROS) generated from oxygen molecules in the presence of photosensitizers (PS) under laser excitation [ 50 ].…”

Section: Introductionmentioning

confidence: 99%

Research Progress of Thermosensitive Hydrogel in Tumor Therapeutic

Yan

2021

Nanoscale Res Lett

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Compared with traditional tumor therapy strategies, hydrogel as a drug reservoir system can realize on-demand drug release and deep tissue penetration ability. It also exhibits great tumor-site retention to enhance the permeability and retention effect of tumor treatment. This can significantly overcome the drug's resistance and severe side effects. Inorganic/organic composite hydrogel has attracted wide attention due to its combined effects, enhancing therapeutic effects against various kinds of tumors. In situ injectable hydrogel can securely restrict the drugs in the lesion sites without leakage and guarantee better biosafety. Moreover, hydrogel possesses interconnected macropores which can provide enough space for nutrient transport, cellular activity, and cell–cell interactions. Thermal therapy is an effective strategy for tumor therapy due to its minimal invasiveness and high selectivity. Because the location temperature can be precisely controlled and helps avoid the risks of destroying the body's immune system and ablate normal cells, thermal therapy exhibits significant treatment outcomes. Nonetheless, when the cellular temperature reaches approximately 43 °C, it causes long-term cell inactivation. Based on these merits, thermosensitive hydrogel formulation with adaptive functions shows excellent efficacy, unlimited tissue penetration capacity, and few deleterious side effects. Furthermore, the thermosensitive hydrogel has unique physical properties under the external stimuli, which is the ideal drug delivery system for on-demand release in tumor treatment. This article will review the state of the thermosensitive hydrogel in clinic application for cancer therapy.

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“…Humic acids and fulvic acids (FAs) are the major components of humus compounds. 8 Among them, FA is the most active organic acid with a small molecular weight and high physiological activity. 9 It is mainly because FA is a complex mixture composed of a series of molecules.…”

Section: Introductionmentioning

confidence: 99%

Effects of fulvic acid on the photosynthetic and physiological characteristics of Paeonia ostii under drought stress

Fang

Wang

Zhang

et al. 2020

Plant Signaling & Behavior

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Paeonia ost ii has become an economically important oil crop in recent years, but its growth is seriously affected by drought stress in dry areas. In this study, the alleviating effect of fulvic acid (FA) on potted P. ostii under natural drought stress was investigated. The natural drought stress adopted in this experiment was mainly characterized by the low soil water content, and the roots of plants cannot absorb enough water to compensate for the consumption of transpiration, which affects the normal physiological activities and causes damage. The results showed that FA treatment significantly increased the leaf water content and antioxidant enzyme activities and decreased reactive oxygen species (ROS) accumulation, the proline (Pro) content, and the relative electrical conductivity (REC). Moreover, FA treatment improved photosynthetic parameters and chlorophyll (Chl) fluorescence parameters, maintained the integrity of chloroplasts and mesophyll cells, and increased the expression level of drought-tolerant genes. These results indicated that FA treatment could induce antioxidant enzymes to eliminate ROS, reduce membrane lipid peroxidation and decrease damage to photosynthesis in P. ostii under drought stress, which would provide a measure for alleviating the damage of P. ostii caused by drought stress.

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Natural Humic‐Acid‐Based Phototheranostic Agent

Cited by 39 publications

References 53 publications

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Research Progress of Thermosensitive Hydrogel in Tumor Therapeutic

Effects of fulvic acid on the photosynthetic and physiological characteristics of Paeonia ostii under drought stress

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