Natural immunity and HIV disease progression

Ullum, Henrik; Lepri, Alessandro Cozzi; Aladdin, Hassan; Katzenstein, Terese L.; Victor, Jette; Phillips, Andrew; Gerstoft, Jan; Skinhøj, Peter; Pedersen, Bente Klarlund

doi:10.1097/00002030-199904010-00004

Cited by 52 publications

(30 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At 6 months postenrollment, depressed LAK activity was still evident in the chronically evolving patient group. Deficient IL-2-induced LAK activity has been associated with human immunodeficiency virus progression (5,38), but its involvement in determining the outcome of HCV infection has not previously been reported. Impaired IL-2-mediated LAK predates the development of chronicity, indicating that the cytolytic activity of CD56 pos NT cells may be an important host antiviral effector function for the resolution of HCV in the acute setting.…”

Section: Cd56mentioning

confidence: 99%

Phenotypic and Functional Changes of Cytotoxic CD56^posNatural T Cells Determine Outcome of Acute Hepatitis C Virus Infection

Golden-Mason

Castelblanco

O’Farrelly

et al. 2007

J Virol

View full text Add to dashboard Cite

Innate CD56pos natural killer (NK) and natural T (NT) cells comprise important hepatic antiviral effector lymphocytes whose activity is fine-tuned through surface NK receptors (NKRs). Dysregulation of NKRs in patients with long-standing hepatitis C virus (HCV) infection has been shown, but little is known regarding NKRs in acute infection. Treatment-naïve patients with acute HCV (n ‫؍‬ 22), including 10 with spontaneous recovery, were prospectively studied. CD56 pos NT levels were reduced early in acute HCV infection and did not fluctuate over time. In resolving HCV infection, NT cells with a more activated phenotype (lower CD158A and higher natural cytotoxicity receptor expression) at baseline predated spontaneous recovery. Moreover, NKG2A expression on CD56؉ NT cells correlated directly with circulating HCV RNA levels. Deficient interleukin-13 (IL-13) production by NT cells and reduced IL-2-activated killing (LAK) at baseline were associated with the ultimate development of persistence. These results indicate a previously unappreciated role for NT cells in acute HCV infection and identify a potential target for pharmacologic manipulation.

show abstract

Section: Cd56mentioning

confidence: 99%

Phenotypic and Functional Changes of Cytotoxic CD56^posNatural T Cells Determine Outcome of Acute Hepatitis C Virus Infection

Golden-Mason

Castelblanco

O’Farrelly

et al. 2007

J Virol

View full text Add to dashboard Cite

show abstract

“…The observed decrease in NK activity in this study (during the weeks following IL-2 therapy), which was associated with a fall in circulating CD3 ¹ /CD56 þ NK effector cells, indicates that improvement in NK-cell function during IL-2 therapy is of limited duration. We have recently demonstrated that an impaired LAK cell activity is associated with an increased risk of disease progression [33]. The reduced LAK cell activity after treatment may therefore indicate that IL-2 treatment is associated with immunological defects that can increase the risk of disease progression.…”

Section: Immunological Effects Of Il-2 Therapy In Hiv Infectionmentioning

confidence: 99%

Effects of Subcutaneous Interleukin‐2 Therapy on Phenotype and Function of Peripheral Blood Mononuclear Cells in Human Immunodeficiency Virus Infected Patients

et al. 2000

View full text Add to dashboard Cite

In the context of clinical therapy with recombinant human interleukin‐2 (IL‐2), we monitored immunological alteration in 10 human immunodeficiency virus type‐1 (HIV‐1)‐infected individuals, on stable antiretroviral therapy, who had a CD4+ cell count between 200 and 500 cells/mm3. Subcutaneous IL‐2 was prescribed thrice weekly (at a dose of 3 × 106 IU) for 24 weeks and the patients were followed‐up for 32 weeks. IL‐2 treatment induced an increase in the CD4+ percentage (P < 0.001) and CD4+ cell count (P < 0.009). Furthermore, natural killer (NK) cell activity was increased (P < 0.001) at week 8 of treatment, whereas lymphokine‐activated killer (LAK) cell activity showed a transient, nonsignificant increase at week 8 and was reduced (P < 0.001) at 32 weeks. However, the cytotoxic T‐lymphocyte (CTL) activity decreased against HIV antigens, and the proliferative response to Candida, IL‐2 and phytohaemagglutinin (PHA) declined during the first 8 weeks (P < 0.05) and returned to baseline levels after 32 weeks. The HIV RNA level did not change during IL‐2 therapy; however, after 8 weeks of follow‐up a significant increase (P < 0.001) in viral load was observed. In conclusion, continuous IL‐2 treatment to HIV‐infected individuals enhanced the CD4 count, but the in vitro lymphocyte function was impaired and an increase in viral replication occurred after treatment.

show abstract

“…NK-cell function is severely compromised in HIVinfected individuals and tends to decline with disease progression [2,12,13], whereas the enhanced NK-cellmediated cytotoxic activity has been observed in the early phase of acute HBV infection [14]. However, no information is available concerning NK-cell activity in heavily immunocompromised HIV-infected patients with HBV-related ALF.…”

Section: Introductionmentioning

confidence: 99%

Natural Killer‐Cell Cytotoxicity in HIV‐Positive and HIV‐Negative Patients with and Without Severe Course of Hepatitis B Virus Infection

Morsica¹,

Tasca²,

Biswas³

et al. 2005

Scand J Immunol

View full text Add to dashboard Cite

Natural killer (NK) cells represent the first line of defence against viral infections but, in the case of hepatitis B virus (HBV), may also be involved in liver injury. We here compared NK-cell activity of 11 patients with acute HBV infection, either HIV-positive or HIV-negative, with that of 11 healthy subjects. One of the HIV-positive patients, characterized by a severe immunodeficiency, died 3 weeks after hospitalization for HBV-related fulminant hepatitis (FH). He displayed a remarkable NK-cell cytotoxicity against both cell lines and autologous dendritic cells, whereas the NK-cell activity of the remaining patients was significantly reduced as compared with healthy individuals. Our findings suggest that NK-cell-mediated cytotoxicity could contribute to the development of HBV-related acute liver failure in HIV-positive patients with severe immunodeficiency. An immunopathological model of FH in immunocompromised patients was proposed.

show abstract

Natural immunity and HIV disease progression

Abstract: The present study suggests that low LAK cell activity and low NK cell responsiveness to interferon-alpha may be important in the pathogenesis of HIV infection.

Cited by 52 publications

References 15 publications

Phenotypic and Functional Changes of Cytotoxic CD56^posNatural T Cells Determine Outcome of Acute Hepatitis C Virus Infection

Phenotypic and Functional Changes of Cytotoxic CD56^posNatural T Cells Determine Outcome of Acute Hepatitis C Virus Infection

Effects of Subcutaneous Interleukin‐2 Therapy on Phenotype and Function of Peripheral Blood Mononuclear Cells in Human Immunodeficiency Virus Infected Patients

Natural Killer‐Cell Cytotoxicity in HIV‐Positive and HIV‐Negative Patients with and Without Severe Course of Hepatitis B Virus Infection

Contact Info

Product

Resources

About

Natural immunity and HIV disease progression

Abstract: The present study suggests that low LAK cell activity and low NK cell responsiveness to interferon-alpha may be important in the pathogenesis of HIV infection.

Cited by 52 publications

References 15 publications

Phenotypic and Functional Changes of Cytotoxic CD56posNatural T Cells Determine Outcome of Acute Hepatitis C Virus Infection

Phenotypic and Functional Changes of Cytotoxic CD56posNatural T Cells Determine Outcome of Acute Hepatitis C Virus Infection

Effects of Subcutaneous Interleukin‐2 Therapy on Phenotype and Function of Peripheral Blood Mononuclear Cells in Human Immunodeficiency Virus Infected Patients

Natural Killer‐Cell Cytotoxicity in HIV‐Positive and HIV‐Negative Patients with and Without Severe Course of Hepatitis B Virus Infection

Contact Info

Product

Resources

About

Phenotypic and Functional Changes of Cytotoxic CD56^posNatural T Cells Determine Outcome of Acute Hepatitis C Virus Infection

Phenotypic and Functional Changes of Cytotoxic CD56^posNatural T Cells Determine Outcome of Acute Hepatitis C Virus Infection